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    ThrRS Threonyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45784, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ThrRSprovided by FlyBase
    Official Full Name
    Threonyl-tRNA synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027081
    Locus tag
    Dmel_CG5353
    See related
    AllianceGenome:FB:FBgn0027081
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2L16; 42/3; Aats-thr; CG5353; Dmel\CG5353; dTARS; l(2)k04203; P539; TARS; threonyl-tRNA synthetase; TRS
    Summary
    Predicted to enable aminoacyl-tRNA editing activity and threonine-tRNA ligase activity. Predicted to be involved in threonyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gland; gut section; and larval muscle cell. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 21 and nonphotosensitive trichothiodystrophy 7. Orthologous to several human genes including TARS1 (threonyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ThrRS in Genome Data Viewer
    Location:
    33C4-33C4; 2-46 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12103751..12107170)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12103751..12107170)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Methyltransferase 2 Neighboring gene Ced-12 Neighboring gene patsas Neighboring gene Rab6 Neighboring gene Phaedra 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. QTL mapping of natural variation reveals that the developmental regulator bruno reduces tolerance to P-element transposition in the Drosophila female germline. Kelleher ES, et al. PLoS Biol, 2018 Oct. PMID 30376574, Free PMC Article
    2. The developmental role of warthog, the notch modifier encoding Drab6. Purcell K, et al. J Cell Biol, 1999 Aug 23. PMID 10459009, Free PMC Article
    3. Changes in Drosophila melanogaster midgut proteins in response to dietary Bowman-Birk inhibitor. Li HM, et al. Insect Mol Biol, 2007 Oct. PMID 17725801
    4. WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland. Seshaiah P, et al. Mol Biol Cell, 1999 May. PMID 10233165, Free PMC Article
    5. Asparaginyl-tRNA Synthetase, a Novel Component of Hippo Signaling, Binds to Salvador and Enhances Yorkie-Mediated Tumorigenesis. Yeom E, et al. Front Cell Dev Biol, 2020. PMID 32117966, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables threonine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables threonine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables threonine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in threonyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in threonyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in threonyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Threonyl-tRNA synthetase
    Names
    CG5353-PA
    CG5353-PB
    CG5353-PC
    CG5353-PD
    ThrRS-PA
    ThrRS-PB
    ThrRS-PC
    ThrRS-PD
    threonyl-tRNA synthetase
    NP_001285868.1
    NP_524839.3
    NP_723725.1
    NP_723726.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12103751..12107170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298939.1 → NP_001285868.1  Threonyl-tRNA synthetase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285868.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRL7, Q9VKB0
      Conserved Domains (5) summary
      cd01667
      Location:109 → 170
      TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
      PLN02908
      Location:79 → 740
      PLN02908; threonyl-tRNA synthetase
      smart00863
      Location:276 → 323
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
      cd00771
      Location:347 → 643
      ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00860
      Location:643 → 734
      ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

    2. NM_164994.3 → NP_723725.1  Threonyl-tRNA synthetase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723725.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRL7, Q9VKB0
      Related
      FBpp0079914
      Conserved Domains (5) summary
      cd01667
      Location:109 → 170
      TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
      PLN02908
      Location:79 → 740
      PLN02908; threonyl-tRNA synthetase
      smart00863
      Location:276 → 323
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
      cd00771
      Location:347 → 643
      ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00860
      Location:643 → 734
      ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

    3. NM_080100.6 → NP_524839.3  Threonyl-tRNA synthetase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524839.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGC5, Q8IP94
      Related
      FBpp0079913
      Conserved Domains (5) summary
      cd01667
      Location:52 → 113
      TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
      PLN02908
      Location:1 → 683
      PLN02908; threonyl-tRNA synthetase
      smart00863
      Location:219 → 266
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
      cd00771
      Location:290 → 586
      ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00860
      Location:586 → 677
      ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

    4. NM_164995.2 → NP_723726.1  Threonyl-tRNA synthetase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723726.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGC5, Q8IP94
      Related
      FBpp0079915
      Conserved Domains (5) summary
      cd01667
      Location:52 → 113
      TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
      PLN02908
      Location:1 → 683
      PLN02908; threonyl-tRNA synthetase
      smart00863
      Location:219 → 266
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
      cd00771
      Location:290 → 586
      ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00860
      Location:586 → 677
      ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGC5 Q8IGC5
    Q8IP94 Q8IP94
    Q8MRL7 Q8MRL7
    Q9VKB0 Q9VKB0

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