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    Liprin-gamma Liprin-gamma [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37552, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Liprin-gammaprovided by FlyBase
    Official Full Name
    Liprin-gammaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034720
    Locus tag
    Dmel_CG11206
    See related
    AllianceGenome:FB:FBgn0034720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11206; Dmel\CG11206; liprin; Liprin CG11206; liprin gamma; lipringamma
    Summary
    Enables protein homodimerization activity. Involved in axon target recognition and negative regulation of synaptic assembly at neuromuscular junction. Part of protein-containing complex. Is expressed in central nervous system; embryonic brain; eye disc; eye disc morphogenetic furrow; and larval ventral nerve cord. Orthologous to human KAZN (kazrin, periplakin interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Liprin-gamma in Genome Data Viewer
    Location:
    58D3-58D4; 2-99 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22333500..22373109, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18221005..18260614, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Gp150 Neighboring gene uncharacterized protein Neighboring gene Type III alcohol dehydrogenase Neighboring gene uncharacterized protein Neighboring gene polar granule component Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44759 Neighboring gene long non-coding RNA:CR45327 Neighboring gene Rtf1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Liprin-alpha has LAR-independent functions in R7 photoreceptor axon targeting. Hofmeyer K, et al. Proc Natl Acad Sci U S A, 2006 Aug 1. PMID 16864797, Free PMC Article
    2. Transient transcriptional silencing alters the cell cycle to promote germline stem cell differentiation in Drosophila. Flora P, et al. Dev Biol, 2018 Feb 1. PMID 29198563, Free PMC Article
    3. A comparison of midline and tracheal gene regulation during Drosophila development. Long SK, et al. PLoS One, 2014. PMID 24465586, Free PMC Article
    4. Common motifs shared by conserved enhancers of Drosophila midline glial genes. Fulkerson E, et al. J Exp Zool B Mol Dev Evol, 2011 Jan 15. PMID 21154525
    5. Three Drosophila liprins interact to control synapse formation. Astigarraga S, et al. J Neurosci, 2010 Nov 17. PMID 21084592, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c22351469-22349755 mobile_element_type = transposon:jockey{}869

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon target recognition IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of synaptic assembly at neuromuscular junction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Liprin-gamma
    Names
    CG11206-PA
    CG11206-PB
    CG11206-PC
    CG11206-PD
    CG11206-PE
    Liprin-gamma-PA
    Liprin-gamma-PB
    Liprin-gamma-PC
    Liprin-gamma-PD
    Liprin-gamma-PE
    liprin gamma
    liprin-gamma

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22333500..22373109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137819.4 → NP_611663.2  Liprin-gamma, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611663.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W263
      Conserved Domains (5) summary
      cd09564
      Location:589 → 658
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:667 → 731
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:753 → 824
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      smart00454
      Location:676 → 731
      SAM; Sterile alpha motif
      pfam07106
      Location:212 → 308
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

    2. NM_001299787.1 → NP_001286716.1  Liprin-gamma, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286716.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LG34
      Conserved Domains (5) summary
      cd09564
      Location:648 → 717
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:726 → 790
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:812 → 883
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      smart00454
      Location:735 → 790
      SAM; Sterile alpha motif
      pfam07106
      Location:271 → 367
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

    3. NM_206200.3 → NP_995922.2  Liprin-gamma, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995922.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W263
      Conserved Domains (5) summary
      cd09564
      Location:589 → 658
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:667 → 731
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:753 → 824
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      smart00454
      Location:676 → 731
      SAM; Sterile alpha motif
      pfam07106
      Location:212 → 308
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

    4. NM_001103944.2 → NP_001097414.1  Liprin-gamma, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097414.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYM0
      Conserved Domains (5) summary
      cd09564
      Location:718 → 787
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:796 → 860
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:882 → 953
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      smart00454
      Location:805 → 860
      SAM; Sterile alpha motif
      pfam07106
      Location:341 → 437
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

    5. NM_001103945.2 → NP_001097415.1  Liprin-gamma, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097415.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYM1
      Conserved Domains (5) summary
      cd09564
      Location:589 → 658
      SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
      cd09567
      Location:667 → 731
      SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
      cd09570
      Location:753 → 824
      SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
      smart00454
      Location:676 → 731
      SAM; Sterile alpha motif
      pfam07106
      Location:212 → 308
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LG34 A0A0B4LG34
    A8DYM0 A8DYM0
    A8DYM1 A8DYM1
    Q9W263 Q9W263

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