U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    eIF3m eukaryotic translation initiation factor 3 subunit m [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36565, updated on 9-Dec-2024

    Summary

    Official Symbol
    eIF3mprovided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 3 subunit mprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033902
    Locus tag
    Dmel_CG8309
    See related
    AllianceGenome:FB:FBgn0033902
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey67; anon-EST:Posey76; CG8309; Dmel\CG8309; eIF3M; Tango 7; tango7; Tango7; TANGO7; Tng7
    Summary
    Enables caspase binding activity and cysteine-type endopeptidase activator activity. Involved in Golgi organization; protein secretion; and sperm individualization. Located in Golgi apparatus; cytosol; and investment cone. Is expressed in adult head; embryonic hindgut; embryonic/larval midgut; and organism. Orthologous to human EIF3M (eukaryotic translation initiation factor 3 subunit M). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See eIF3m in Genome Data Viewer
    Location:
    50E1-50E1; 2-69 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14163066..14164825, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10050571..10052330, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cysteinyl-tRNA synthetase, mitochondrial Neighboring gene O-fucosyltransferase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44368 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables caspase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cysteine-type endopeptidase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation initiation factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytoplasmic translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of eukaryotic translation initiation factor 3 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of eukaryotic translation initiation factor 3 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in investment cone IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 3 subunit m
    Names
    CG8309-PA
    CG8309-PB
    eIF3m-PA
    eIF3m-PB
    transport and golgi organization 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14163066..14164825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137088.4NP_610932.1  eukaryotic translation initiation factor 3 subunit m, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610932.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JVI3
      UniProtKB/TrEMBL
      A0A0B4LFB3
      Related
      FBpp0086705
      Conserved Domains (2) summary
      pfam01399
      Location:236336
      PCI; PCI domain
      pfam18005
      Location:341369
      eIF3m_C_helix; eIF3 subunit M, C-terminal helix
    2. NM_001299478.1NP_001286407.1  eukaryotic translation initiation factor 3 subunit m, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286407.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JVI3
      UniProtKB/TrEMBL
      A0A0B4LFB3
      Conserved Domains (2) summary
      pfam01399
      Location:236336
      PCI; PCI domain
      pfam18005
      Location:341369
      eIF3m_C_helix; eIF3 subunit M, C-terminal helix