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    tau tau [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326116, updated on 17-Dec-2024

    Summary

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    Official Symbol
    tauprovided by FlyBase
    Official Full Name
    tauprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266579
    Locus tag
    Dmel_CG45110
    See related
    AllianceGenome:FB:FBgn0266579
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE16764; CG12881; CG31057; CG31058; CG34294; CG45110; CG5606; d-tau; Dmel\CG45110; dtau; dTau; dTAU; tao; Tau
    Old locus tag
    Dmel_CG31057; Dmel_CG31058; Dmel_CG34294
    Summary
    Enables microtubule binding activity. Involved in microtubule cytoskeleton organization; open tracheal system development; and rhabdomere morphogenesis. Located in axon and dendrite. Colocalizes with cytoplasmic microtubule. Is expressed in several structures, including brain; chordotonal organ; head; imaginal disc; and synaptic neuropil domain. Used to study Pick's disease; amnestic disorder; frontotemporal dementia; neurodegenerative disease; and tauopathy. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Orthologous to human MAPT (microtubule associated protein tau). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tau in Genome Data Viewer
    Location:
    98A13-98A14; 3-94 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27639886..27656996, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23465608..23482718, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene tusp Neighboring gene uncharacterized protein Neighboring gene Mig-2-like Neighboring gene mir-1001 stem loop Neighboring gene Ribosomal protein S10a Neighboring gene Myosin alkali light chain 1 Neighboring gene uncoordinated 80

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Moderate Overexpression of Tau in Drosophila Exacerbates Amyloid-β-Induced Neuronal Phenotypes and Correlates with Tau Oligomerization. Miguel L, et al. J Alzheimers Dis, 2020. PMID 32065789
    2. Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo. Cowan CM, et al. Acta Neuropathol, 2010 Nov. PMID 20617325
    3. The power and richness of modelling tauopathies in Drosophila. Papanikolopoulou K, et al. Mol Neurobiol, 2011 Aug. PMID 21681411
    4. Effects of tau on Aβ-induced synaptic damage in a Drosophila model of Alzheimer's disease. Wang Q, et al. Neuro Endocrinol Lett, 2022 Jun 7. PMID 35786817
    5. Sex-Differences in Traumatic Brain Injury in the Absence of Tau in Drosophila. Shah EJ, et al. Genes (Basel), 2021 Jun 14. PMID 34198629, Free PMC Article

    See all (197) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of high-fat diet-induced miRNA ameliorates tau toxicity in Drosophila.
      Title: Inhibition of high-fat diet-induced miRNA ameliorates tau toxicity in Drosophila.
    2. Tau suppresses microtubule-regulated pancreatic insulin secretion.
      Title: Tau suppresses microtubule-regulated pancreatic insulin secretion.
    3. Mical modulates Tau toxicity via cysteine oxidation in vivo.
      Title: Mical modulates Tau toxicity via cysteine oxidation in vivo.
    4. Microtubule affinity-regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
      Title: Microtubule affinity-regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
    5. Photodynamic exposure of Rose-Bengal inhibits Tau aggregation and modulates cytoskeletal network in neuronal cells.
      Title: Photodynamic exposure of Rose-Bengal inhibits Tau aggregation and modulates cytoskeletal network in neuronal cells.
    6. Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer's Disease.
      Title: Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer's Disease.
    7. We demonstrate that despite modest sequence divergence, the Drosophila tau (dTau) is a true vertebrate tau ortholog as it interacts with the neuronal microtubule and actin cytoskeleton. Novel physiological roles for dTau in regulation of translation, long-term memory, and footshock habituation are also revealed.
      Title: Drosophila Tau Negatively Regulates Translation and Olfactory Long-Term Memory, But Facilitates Footshock Habituation and Cytoskeletal Homeostasis.
    8. polyadenylated RNAs accumulate within and adjacent to tau-induced nuclear envelope invaginations in a Drosophila model of tauopathy.
      Title: Tau-induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila.
    9. Our collective data demonstrate the complexity of 14-3-3/Tau interactions in vivo and suggest that 14-3-3 attenuation is not appropriate ameliorative treatment of Tauopathies. Finally, we suggest that 'bystander' 14-3-3s are recruited by accumulating Tau with the consequences depending on the composition of available dimers within particular neurons and the Tau variant.
      Title: Differential effects of 14-3-3 dimers on Tau phosphorylation, stability and toxicity in vivo.
    10. The comprehensive pathological and molecular data generated through this study strongly validate the causal role of TREM2/TYROBP in driving molecular networks in Alzheimer's disease (AD) and AD-related phenotypes in flies.[
      Title: Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in branching involved in open tracheal system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lumen formation, open tracheal system IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rhabdomere morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tau
    Names
    CG45110-PA
    CG45110-PB
    CG45110-PC
    CG45110-PE
    CG45110-PF
    CG45110-PG
    CG45110-PH
    CG45110-PI
    CG45110-PJ
    CG45110-PK
    CG45110-PL
    CG45110-PM
    CG45110-PN
    CG45110-PO
    tau-PA
    tau-PB
    tau-PC
    tau-PE
    tau-PF
    tau-PG
    tau-PH
    tau-PI
    tau-PJ
    tau-PK
    tau-PL
    tau-PM
    tau-PN
    tau-PO

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27639886..27656996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300635.1 → NP_001287564.1  tau, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287564.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHR7
      Conserved Domains (1) summary
      pfam00418
      Location:165 → 195
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    2. NM_001300636.1 → NP_001287565.1  tau, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287565.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHS3
      Conserved Domains (1) summary
      pfam00418
      Location:257 → 286
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    3. NM_001300634.1 → NP_001287563.1  tau, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287563.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LIS6
      Conserved Domains (1) summary
      pfam00418
      Location:288 → 316
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    4. NM_001276088.1 → NP_001263017.1  tau, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263017.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95UT1, Q9VB13
      Conserved Domains (1) summary
      pfam00418
      Location:288 → 316
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    5. NM_001276090.2 → NP_001263019.2  tau, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263019.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KI45
      Conserved Domains (1) summary
      pfam00418
      Location:257 → 286
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    6. NM_143318.3 → NP_651575.1  tau, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651575.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95UT1, Q9VB13
      Related
      FBpp0311073
      Conserved Domains (1) summary
      pfam00418
      Location:288 → 316
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    7. NM_001276089.1 → NP_001263018.1  tau, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263018.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHQ8
      Conserved Domains (1) summary
      pfam00418
      Location:288 → 316
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    8. NM_001316620.1 → NP_001303549.1  tau, isoform N [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A126GV16
      Conserved Domains (1) summary
      pfam00418
      Location:288 → 316
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    9. NM_001300639.1 → NP_001287568.1  tau, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287568.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LIT4
      Conserved Domains (1) summary
      pfam00418
      Location:296 → 322
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    10. NM_001382126.1 → NP_001369032.1  tau, isoform O [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EDU2

    11. NM_170345.3 → NP_733224.2  tau, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733224.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VB15
      Conserved Domains (1) summary
      pfam00418
      Location:644 → 672
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    12. NM_001300637.1 → NP_001287566.1  tau, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287566.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHV0
      Conserved Domains (2) summary
      PHA03309
      Location:15 → 88
      PHA03309; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:205 → 233
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    13. NM_001300638.1 → NP_001287567.1  tau, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287567.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHV0
      Conserved Domains (2) summary
      PHA03309
      Location:15 → 88
      PHA03309; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:205 → 233
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    14. NM_001276091.1 → NP_001263020.1  tau, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263020.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMW4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHQ8 A0A0B4KHQ8
    A0A0B4KI45 A0A0B4KI45
    A0A0B4LHR7 A0A0B4LHR7
    A0A0B4LHS3 A0A0B4LHS3
    A0A0B4LHV0 A0A0B4LHV0
    A0A0B4LIS6 A0A0B4LIS6
    A0A0B4LIT4 A0A0B4LIT4
    A0A126GV16 A0A126GV16
    A0A6H2EDU2 A0A6H2EDU2
    D3DMW4 D3DMW4
    Q9VB13 Q9VB13
    Q9VB15 Q9VB15

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