X11L X11L [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: X11Lprovided by FlyBase
Official Full Name: X11Lprovided by FlyBase
Primary source: FLYBASE:FBgn0026313
Locus tag: Dmel_CG5675
See related: AllianceGenome:FB:FBgn0026313
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5675; CG5678; Dmel\CG5675; Dmint; Dmint1; dX11; dX11/Mint; dX11L; dX11Lalpha; Mint; MINT; X11; X11-like; x11/Mint; X11/Mint; x11Lalpha; X11Lalpha
Summary: Enables cell adhesion molecule binding activity. Involved in compound eye development and protein localization to membrane. Located in Golgi apparatus; axon; and neuronal cell body. Colocalizes with plasma membrane. Is expressed in several structures, including adult optic lobe; embryonic/larval mushroom body; eye disc; ganglia; and interommatidial precursor cell. Orthologous to several human genes including APBA1 (amyloid beta precursor protein binding family A member 1) and APBA2 (amyloid beta precursor protein binding family A member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 16B7-16B7; 1-57 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (17599608..17606879)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (17493641..17500912)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that X11/Mint-dependent endocytosis in dendrites may serve to promote the axonal localization of membrane proteins.
Title: X11/Mint genes control polarized localization of axonal membrane proteins in vivo.
studies identify X11L and ubiquilin as in vivo regulators of amyloid precursor protein
Title: Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila.
The adaptor protein X11Lalpha/Dmint1 interacts with the PDZ-binding domain of the cell recognition protein Rst in Drosophila
Title: The adaptor protein X11Lalpha/Dmint1 interacts with the PDZ-binding domain of the cell recognition protein Rst in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: X11L

Names: CG5675-PA; CG5675-PB; CG5675-PC; CG5675-PE; CG5675-PF; X11-like; X11/Mint; X11L-PA; X11L-PB; X11L-PC; X11L-PE; X11L-PF; dX11/Mint/Lin-10

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

17599608..17606879

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298447.1 → NP_001285376.1 X11L, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285376.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9GQQ6, X2JE74

Conserved Domains (2) summary

cd00992
Location:1092 → 1151

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:775 → 954

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
NM_001169310.2 → NP_001162781.1 X11L, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162781.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJN6, Q9GQQ6

Conserved Domains (2) summary

cd00992
Location:1090 → 1149

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:775 → 952

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
NM_001272726.2 → NP_001259655.2 X11L, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259655.2

Status: REVIEWED

UniProtKB/TrEMBL

M9PF12, Q9GQQ6

Conserved Domains (2) summary

cd00992
Location:1084 → 1143

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:770 → 946

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
NM_132996.4 → NP_573224.2 X11L, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_573224.2

Status: REVIEWED

UniProtKB/TrEMBL

Q960Z2, Q9GQQ6, Q9VX41

Related

FBpp0074225

Conserved Domains (2) summary

cd00992
Location:1089 → 1148

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:774 → 951

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
NM_001272725.2 → NP_001259654.1 X11L, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259654.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJN6, Q9GQQ6

Conserved Domains (2) summary

cd00992
Location:1090 → 1149

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:775 → 952

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain