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    fiz fezzik [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32420, updated on 17-Dec-2024

    Summary

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    Official Symbol
    fizprovided by FlyBase
    Official Full Name
    fezzikprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030594
    Locus tag
    Dmel_CG9509
    See related
    AllianceGenome:FB:FBgn0030594
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9509; Dm GMCbeta2; Dmel\CG9509
    Summary
    Predicted to enable oxidoreductase activity. Involved in mesoderm development. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fiz in Genome Data Viewer
    Location:
    13A1-13A1; 1-49 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14906334..14909708, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14800367..14803741, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Flotillin 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sexual Antagonism, Temporally Fluctuating Selection, and Variable Dominance Affect a Regulatory Polymorphism in Drosophila melanogaster. Glaser-Schmitt A, et al. Mol Biol Evol, 2021 Oct 27. PMID 34289067, Free PMC Article
    2. Selective sweep of a cis-regulatory sequence in a non-African population of Drosophila melanogaster. Saminadin-Peter SS, et al. Mol Biol Evol, 2012 Apr. PMID 22101416
    3. Adaptive divergence of a transcriptional enhancer between populations of Drosophila melanogaster. Glaser-Schmitt A, et al. Philos Trans R Soc Lond B Biol Sci, 2013 Dec 19. PMID 24218636, Free PMC Article
    4. Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons. Grenier T, et al. Elife, 2023 Jun 9. PMID 37294006, Free PMC Article
    5. Rapid evolutionary change, constraints and the maintenance of polymorphism in natural populations of Drosophila melanogaster. Glaser-Schmitt A, et al. Mol Ecol, 2024 May. PMID 37222070

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ecdysteroid metabolic process IGC
    Inferred from Genomic Context
    more info
    		 PubMed 
    involved_in ecdysteroid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mesoderm development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fezzik
    Names
    CG9509-PA
    CG9509-PB
    fiz-PA
    fiz-PB
    NP_001285254.1
    NP_572983.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      14906334..14909708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298325.1 → NP_001285254.1  fezzik, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285254.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VY04, T1W1X8
      Conserved Domains (3) summary
      PRK02106
      Location:66 → 621
      PRK02106; choline dehydrogenase; Validated
      pfam05199
      Location:472 → 617
      GMC_oxred_C; GMC oxidoreductase
      cl21454
      Location:142 → 359
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_132755.3 → NP_572983.1  fezzik, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572983.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VY04, T1W1X8
      Related
      FBpp0073795
      Conserved Domains (3) summary
      PRK02106
      Location:66 → 621
      PRK02106; choline dehydrogenase; Validated
      pfam05199
      Location:472 → 617
      GMC_oxred_C; GMC oxidoreductase
      cl21454
      Location:142 → 359
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSW2 Q8MSW2
    Q9VY04 Q9VY04

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