Tomosyn tomosyn [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tomosynprovided by FlyBase
Official Full Name: tomosynprovided by FlyBase
Primary source: FLYBASE:FBgn0030412
Locus tag: Dmel_CG17762
See related: AllianceGenome:FB:FBgn0030412
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RH19475; CG11056; CG17762; CG2205; Dmel\CG17762; tomosyn
Summary: Predicted to enable GTPase activator activity; myosin II binding activity; and syntaxin binding activity. Involved in long-term memory and regulation of neuromuscular synaptic transmission. Located in neuromuscular junction. Is expressed in adult head; embryonic/larval neuromuscular junction; and organism. Orthologous to several human genes including STXBP5 (syntaxin binding protein 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 11B6-11B7; 1-39 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (12631605..12653442)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (12525638..12547475)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The decoy SNARE Tomosyn sets tonic versus phasic release properties and is required for homeostatic synaptic plasticity.
Title: The decoy SNARE Tomosyn sets tonic versus phasic release properties and is required for homeostatic synaptic plasticity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	ISS Inferred from Sequence or Structural Similarity more info
enables myosin II binding	IBA Inferred from Biological aspect of Ancestor more info
enables syntaxin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to plasma membrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tomosyn

Names: CG17762-PC; CG17762-PF; CG17762-PH; CG17762-PI; CG17762-PJ; CG17762-PK; CG17762-PL; Tomosyn-PC; Tomosyn-PF; Tomosyn-PH; Tomosyn-PI; Tomosyn-PJ; Tomosyn-PK; Tomosyn-PL; tomosyn ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

12631605..12653442

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_132591.5 → NP_572819.4 tomosyn, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572819.4

Status: REVIEWED

UniProtKB/TrEMBL

A4V4D2

Conserved Domains (5) summary

COG2319
Location:55 → 257

WD40; WD40 repeat [General function prediction only]

cd15873
Location:1187 → 1247

R-SNARE_STXBP5_6; SNARE domain of STXBP5, STXBP6 and related proteins

pfam08366
Location:269 → 375

LLGL; LLGL2

sd00039
Location:95 → 133

7WD40; WD40 repeat [structural motif]

cl02567
Location:52 → 257

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_167328.4 → NP_727628.3 tomosyn, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727628.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9VYK4, Q9VYK6

Conserved Domains (5) summary

COG2319
Location:55 → 257

WD40; WD40 repeat [General function prediction only]

cd15873
Location:1403 → 1463

R-SNARE_STXBP5_6; SNARE domain of STXBP5, STXBP6 and related proteins

pfam08366
Location:269 → 375

LLGL; LLGL2

sd00039
Location:95 → 133

7WD40; WD40 repeat [structural motif]

cl02567
Location:52 → 257

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001169264.2 → NP_001162735.1 tomosyn, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162735.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VYK4, Q9VYK6

Conserved Domains (5) summary

COG2319
Location:55 → 257

WD40; WD40 repeat [General function prediction only]

cd15873
Location:1403 → 1463

R-SNARE_STXBP5_6; SNARE domain of STXBP5, STXBP6 and related proteins

pfam08366
Location:269 → 375

LLGL; LLGL2

sd00039
Location:95 → 133

7WD40; WD40 repeat [structural motif]

cl02567
Location:52 → 257

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001169265.2 → NP_001162736.2 tomosyn, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162736.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9VYK5

Conserved Domains (5) summary

COG2319
Location:55 → 257

WD40; WD40 repeat [General function prediction only]

cd15873
Location:1320 → 1380

R-SNARE_STXBP5_6; SNARE domain of STXBP5, STXBP6 and related proteins

pfam08366
Location:269 → 375

LLGL; LLGL2

sd00039
Location:95 → 133

7WD40; WD40 repeat [structural motif]

cl02567
Location:52 → 257

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001258715.2 → NP_001245644.1 tomosyn, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245644.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V4D2

Conserved Domains (5) summary

COG2319
Location:55 → 257

WD40; WD40 repeat [General function prediction only]

cd15873
Location:1187 → 1247

R-SNARE_STXBP5_6; SNARE domain of STXBP5, STXBP6 and related proteins

pfam08366
Location:269 → 375

LLGL; LLGL2

sd00039
Location:95 → 133

7WD40; WD40 repeat [structural motif]

cl02567
Location:52 → 257

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_167329.3 → NP_727629.2 tomosyn, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727629.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9VYK4, Q9VYK6

Related

FBpp0073511

Conserved Domains (5) summary

COG2319
Location:55 → 257

WD40; WD40 repeat [General function prediction only]

cd15873
Location:1403 → 1463

R-SNARE_STXBP5_6; SNARE domain of STXBP5, STXBP6 and related proteins

pfam08366
Location:269 → 375

LLGL; LLGL2

sd00039
Location:95 → 133

7WD40; WD40 repeat [structural motif]

cl02567
Location:52 → 257

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_167330.3 → NP_727630.3 tomosyn, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727630.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9VYK5

Conserved Domains (5) summary

COG2319
Location:55 → 257

WD40; WD40 repeat [General function prediction only]

cd15873
Location:1320 → 1380

R-SNARE_STXBP5_6; SNARE domain of STXBP5, STXBP6 and related proteins

pfam08366
Location:269 → 375

LLGL; LLGL2

sd00039
Location:95 → 133

7WD40; WD40 repeat [structural motif]

cl02567
Location:52 → 257

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...