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    Myh3 myosin, heavy polypeptide 3, skeletal muscle, embryonic [ Mus musculus (house mouse) ]

    Gene ID: 17883, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Myh3provided by MGI
    Official Full Name
    myosin, heavy polypeptide 3, skeletal muscle, embryonicprovided by MGI
    Primary source
    MGI:MGI:1339709
    See related
    Ensembl:ENSMUSG00000020908 AllianceGenome:MGI:1339709
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Myhse; Myhs-e; MyHC-emb
    Summary
    Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in limb E14.5 (RPKM 52.1), CNS E14 (RPKM 5.2) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Myh3 in Genome Data Viewer
    Location:
    11 B3; 11 40.59 cM
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (66969101..66993117)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67078273..67102291)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29791 Neighboring gene transmembrane protein 220 Neighboring gene ADP-ribose/CDP-alcohol diphosphatase, manganese dependent Neighboring gene STARR-seq mESC enhancer starr_29794 Neighboring gene SCO1 cytochrome c oxidase assembly protein Neighboring gene microRNA 6923 Neighboring gene RIKEN cDNA 2310065F04 gene Neighboring gene predicted gene, 31285

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Musculoskeletal defects associated with myosin heavy chain-embryonic loss of function are mediated by the YAP signaling pathway. Bharadwaj A, et al. EMBO Mol Med, 2023 Sep 11. PMID 37492882, Free PMC Article
    2. Clathrin adaptor GGA1 modulates myogenesis of C2C12 myoblasts. Isobe M, et al. PLoS One, 2018. PMID 30440034, Free PMC Article
    3. Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro. Robbins J, et al. J Biol Chem, 1990 Jul 15. PMID 1694848
    4. Myosin heavy chain gene expression in mouse embryoid bodies. An in vitro developmental study. Sánchez A, et al. J Biol Chem, 1991 Nov 25. PMID 1939265
    5. The transcription factor NF-Y participates to stem cell fate decision and regeneration in adult skeletal muscle. Rigillo G, et al. Nat Commun, 2021 Oct 14. PMID 34650038, Free PMC Article

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Musculoskeletal defects associated with myosin heavy chain-embryonic loss of function are mediated by the YAP signaling pathway.
      Title: Musculoskeletal defects associated with myosin heavy chain-embryonic loss of function are mediated by the YAP signaling pathway.
    2. Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development.
      Title: Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in skeletal muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in contractile muscle fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in myofibril IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in myosin filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myosin-3
    Names
    myosin heavy chain 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099635.1 → NP_001093105.1  myosin-3

      See identical proteins and their annotated locations for NP_001093105.1

      Status: REVIEWED

      Source sequence(s)
      AL596129, AL645988
      Consensus CDS
      CCDS36184.1
      UniProtKB/Swiss-Prot
      P13541, Q3V183, Q5SUD4
      Conserved Domains (3) summary
      cd14913
      Location:100 → 767
      MYSc_Myh3; class II myosin heavy chain 3, motor domain
      pfam01576
      Location:847 → 1924
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:35 → 73
      Myosin_N; Myosin N-terminal SH3-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      66969101..66993117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532412.2 → XP_006532475.1  myosin-3 isoform X1

      See identical proteins and their annotated locations for XP_006532475.1

      UniProtKB/Swiss-Prot
      P13541, Q3V183, Q5SUD4
      Related
      ENSMUSP00000104329.2, ENSMUST00000108689.8
      Conserved Domains (3) summary
      cd14913
      Location:100 → 767
      MYSc_Myh3; class II myosin heavy chain 3, motor domain
      pfam01576
      Location:847 → 1924
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:35 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13541.2 GenPept UniProtKB/Swiss-Prot:P13541

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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