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    RPK2 receptor-like protein kinase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821240, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RPK2
    Official Full Name
    receptor-like protein kinase 2
    Primary source
    TAIR:AT3G02130
    Locus tag
    AT3G02130
    See related
    Araport:AT3G02130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CLI1; clv3 peptide insensitive 1; F1C9.8; F1C9_8; receptor-like protein kinase 2; TOAD2; TOADSTOOL 2
    Summary
    Encodes a receptor-like kinase RPK2 (also known as TOADSTOOL 2/TOAD2). Functions as a regulator of meristem maintenance. Mutants are insensitive to synthetic CLV3 peptide. Mutations in the RPK2 also result in stem cell expansion and increased number of floral organs, as seen in the other clv mutants. Forms homo-oligomers.
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    Genomic context

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    See RPK2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (380350..384582)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene pinin-like protein Neighboring gene AFP2 (ABI five-binding protein 2) family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BAM 1 and RECEPTOR-LIKE PROTEIN KINASE 2 constitute a signaling pathway and modulate CLE peptide-triggered growth inhibition in Arabidopsis root. Shimizu N, et al. New Phytol, 2015 Dec. PMID 26083273
    2. Heterotrimeric G proteins control stem cell proliferation through CLAVATA signaling in Arabidopsis. Ishida T, et al. EMBO Rep, 2014 Nov. PMID 25260844, Free PMC Article
    3. Two receptor-like kinases required together for the establishment of Arabidopsis cotyledon primordia. Nodine MD, et al. Dev Biol, 2008 Feb 1. PMID 18158146
    4. RPK1 and TOAD2 are two receptor-like kinases redundantly required for arabidopsis embryonic pattern formation. Nodine MD, et al. Dev Cell, 2007 Jun. PMID 17543866
    5. Receptor-like protein kinase 2 (RPK 2) is a novel factor controlling anther development in Arabidopsis thaliana. Mizuno S, et al. Plant J, 2007 Jun. PMID 17419837

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings suggest that the BAM1 and RPK2 receptors constitute a signaling pathway that modulates cell proliferation in the root meristem and that related molecules are employed in root and shoot meristems.
      Title: BAM 1 and RECEPTOR-LIKE PROTEIN KINASE 2 constitute a signaling pathway and modulate CLE peptide-triggered growth inhibition in Arabidopsis root.
    2. AGB1 and RPK2 work synergistically in stem cell homeostasis through their physical interactions.
      Title: Heterotrimeric G proteins control stem cell proliferation through CLAVATA signaling in Arabidopsis.
    3. Parallel signaling pathways involving CLV1, CLV2, and RPK2 are important for nematode parasitism.
      Title: Synergistic interaction of CLAVATA1, CLAVATA2, and RECEPTOR-LIKE PROTEIN KINASE 2 in cyst nematode parasitism of Arabidopsis.
    4. These observations suggest that RPK2 is an essential component of an independent third pathway for CLV3 signalling
      Title: RPK2 is an essential receptor-like kinase that transmits the CLV3 signal in Arabidopsis.
    5. RPK1 and TOAD2 are primarily required to maintain central domain protoderm cell fate and the loss of this key embryonic cell type in mutant embryos results in defects in other regions of embryo including failure to initiate cotyledon primordia.[TOAD2]
      Title: Two receptor-like kinases required together for the establishment of Arabidopsis cotyledon primordia.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001337381.1
    NM_111080.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anther development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic meristem development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lignin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in longitudinal axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meristem maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pollen germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in radial axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    receptor-like protein kinase 2
    NP_186862.3
    • receptor-like protein kinase 2 (RPK2); FUNCTIONS IN: protein serine/threonine kinase activity, kinase activity, ATP binding; INVOLVED IN: lignin metabolic process, protein amino acid phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway, pollen maturation, anther dehiscence; LOCATED IN: plasma membrane; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: receptor-like protein kinase 1 (TAIR:AT1G69270.1); Has 212351 Blast hits to 140653 proteins in 4689 species: Archae - 161; Bacteria - 19257; Metazoa - 62611; Fungi - 11388; Plants - 92974; Viruses - 608; Other Eukaryotes - 25352 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      380350..384582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111080.4 → NP_186862.3  receptor-like protein kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_186862.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0LGM5, Q8GYR1, Q9S7I6
      UniProtKB/TrEMBL
      A0A178VGT2, A0A5S9X8D3
      Conserved Domains (2) summary
      PLN00113
      Location:17 → 1144
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:146 → 169
      LRR_RI; leucine-rich repeat [structural motif]

    2. NM_001337381.1 → NP_001327243.1  receptor-like protein kinase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LRQ5, A0A5S9X8D3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S7I6.1

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