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    hmgcra 3-hydroxy-3-methylglutaryl-CoA reductase a [ Danio rerio (zebrafish) ]

    Gene ID: 559054, updated on 5-Jan-2025

    Summary

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    Official Symbol
    hmgcraprovided by ZNC
    Official Full Name
    3-hydroxy-3-methylglutaryl-CoA reductase aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040401-2
    See related
    Ensembl:ENSDARG00000052734 AllianceGenome:ZFIN:ZDB-GENE-040401-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hmgcr1; hmgcr1a; zgc:136576; si:ch211-129a6.5
    Summary
    Predicted to enable hydroxymethylglutaryl-CoA reductase (NADPH) activity. Acts upstream of or within skeletal muscle tissue development. Predicted to be located in endoplasmic reticulum; membrane; and peroxisome. Predicted to be active in endoplasmic reticulum membrane and peroxisomal membrane. Is expressed in brain; gut; inner ear; intestine; and liver. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; coronary artery disease (multiple); diabetes mellitus (multiple); muscular disease (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See hmgcra in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (50972746..50992744, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (50326153..50346153, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene arylsulfatase family, member K Neighboring gene ceramide transporter 1a Neighboring gene uncharacterized LOC137495632 Neighboring gene ankyrin repeat domain 31

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Long-term hyperphagia and caloric restriction caused by low- or high-density husbandry have differential effects on zebrafish postembryonic development, somatic growth, fat accumulation and reproduction. Leibold S, et al. PLoS One, 2015. PMID 25799180, Free PMC Article
    2. Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. Thorpe JL, et al. Dev Cell, 2004 Feb. PMID 14960282
    3. Partial cloning, tissue distribution and effects of epigallocatechin gallate on hepatic 3-hydroxy-3-methylglutaryl-CoA reductase mRNA transcripts in goldfish (Carassius auratus). Cocci P, et al. Gene, 2014 Jul 25. PMID 24835314
    4. Coffee polyphenols exert hypocholesterolemic effects in zebrafish fed a high-cholesterol diet. Meguro S, et al. Nutr Metab (Lond), 2013 Oct 3. PMID 24220226, Free PMC Article
    5. Effects of Phenanthrene Exposure on Cholesterol Homeostasis and Cardiotoxicity in Zebrafish Embryos. McGruer V, et al. Environ Toxicol Chem, 2021 Jun. PMID 33523501

    See all (128) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within coenzyme A metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoprenoid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    3-hydroxy-3-methylglutaryl-CoA reductase a
    Names
    3-hydroxy-3-methylglutaryl-Coenzyme A reductase 1a
    3-hydroxy-3-methylglutaryl-Coenzyme A reductase a
    hmgra
    NP_001073446.2
    XP_005165572.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079977.2 → NP_001073446.2  3-hydroxy-3-methylglutaryl-CoA reductase a

      See identical proteins and their annotated locations for NP_001073446.2

      Status: VALIDATED

      Source sequence(s)
      BX000437
      UniProtKB/TrEMBL
      A0A8M1NCE4, A9JSZ0
      Related
      ENSDARP00000088231.3, ENSDART00000097460.5
      Conserved Domains (3) summary
      cd00643
      Location:461 → 867
      HMG-CoA_reductase_classI; Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
      TIGR00920
      Location:1 → 884
      2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
      cl21543
      Location:88 → 218
      MMPL; MMPL family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      50972746..50992744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165515.5 → XP_005165572.1  3-hydroxy-3-methylglutaryl-CoA reductase a isoform X1

      See identical proteins and their annotated locations for XP_005165572.1

      UniProtKB/TrEMBL
      A0A8M1NCE4, A9JSZ0
      Related
      ENSDARP00000124862.1, ENSDART00000149553.2
      Conserved Domains (3) summary
      cd00643
      Location:461 → 867
      HMG-CoA_reductase_classI; Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
      TIGR00920
      Location:1 → 884
      2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
      cl21543
      Location:88 → 218
      MMPL; MMPL family

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394610.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      102394..124470 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001126459.1: Suppressed sequence

      Description
      NM_001126459.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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