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    KALRN kalirin RhoGEF kinase [ Chlorocebus sabaeus (green monkey) ]

    Gene ID: 103228160, updated on 11-Mar-2024

    Summary

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    Gene symbol
    KALRN
    Gene description
    kalirin RhoGEF kinase
    See related
    Ensembl:ENSCSAG00000007752
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Chlorocebus sabaeus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus
    Orthologs
    human mouse all
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    Genomic context

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    See KALRN in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    63
    Annotation release Status Assembly Chr Location
    102 current Vero_WHO_p1.0 (GCF_015252025.1) Unplaced Scaffold NW_023666041.1 (109573807..110217834)
    100 previous assembly Chlorocebus_sabeus 1.1 (GCF_000409795.2) 22 NC_023663.1 (56106677..56820004, complement)

    NW_023666041.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 14 Neighboring gene uncharacterized LOC119625637 Neighboring gene 60S ribosomal protein L7-like Neighboring gene uncharacterized LOC103228153 Neighboring gene small EDRK-rich factor 2-like Neighboring gene uridine monophosphate synthetase Neighboring gene integrin subunit beta 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kalirin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Chlorocebus sabaeus Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Vero_WHO_p1.0

    Genomic

    1. NW_023666041.1 Reference Vero_WHO_p1.0

      Range
      109573807..110217834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038002459.1 → XP_037858387.1  kalirin isoform X8

      UniProtKB/TrEMBL
      A0A0D9R5W9
      Conserved Domains (14) summary
      smart00150
      Location:1135 → 1235
      SPEC; Spectrin repeats
      cd11852
      Location:1649 → 1708
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2293 → 2351
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2537 → 2628
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1284 → 1454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537 → 766
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1461 → 1583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2075 → 2209
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2658 → 2905
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1901 → 2070
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2439 → 2533
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1706 → 1845
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:2431 → 2434
      Ig; Ig strand A [structural motif]

    2. XM_038002455.1 → XP_037858383.1  kalirin isoform X3

      UniProtKB/TrEMBL
      A0A0D9R5W9
      Conserved Domains (14) summary
      smart00150
      Location:1135 → 1235
      SPEC; Spectrin repeats
      cd11852
      Location:1649 → 1708
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2324 → 2382
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2568 → 2659
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1284 → 1454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537 → 766
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1461 → 1583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2106 → 2240
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2689 → 2936
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1932 → 2101
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2470 → 2564
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1706 → 1931
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:2462 → 2465
      Ig; Ig strand A [structural motif]

    3. XM_038002460.1 → XP_037858388.1  kalirin isoform X9

      UniProtKB/TrEMBL
      A0A0D9R5W9
      Conserved Domains (14) summary
      smart00150
      Location:1135 → 1235
      SPEC; Spectrin repeats
      cd11852
      Location:1649 → 1708
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2292 → 2350
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2536 → 2627
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1284 → 1454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537 → 766
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1461 → 1583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2074 → 2208
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2657 → 2904
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1900 → 2069
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2438 → 2532
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1706 → 1844
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:2430 → 2433
      Ig; Ig strand A [structural motif]

    4. XM_038002457.1 → XP_037858385.1  kalirin isoform X6

      UniProtKB/TrEMBL
      A0A0D9R5W9
      Conserved Domains (14) summary
      smart00150
      Location:1122 → 1222
      SPEC; Spectrin repeats
      cd11852
      Location:1636 → 1695
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2312 → 2370
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2556 → 2647
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1271 → 1441
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537 → 753
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1448 → 1570
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2094 → 2228
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2677 → 2924
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1920 → 2089
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2458 → 2552
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1693 → 1919
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:2450 → 2453
      Ig; Ig strand A [structural motif]

    5. XM_038002458.1 → XP_037858386.1  kalirin isoform X7

      UniProtKB/TrEMBL
      A0A0D9R5W9
      Conserved Domains (14) summary
      smart00150
      Location:1113 → 1213
      SPEC; Spectrin repeats
      cd11852
      Location:1627 → 1686
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2303 → 2361
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2547 → 2638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1262 → 1432
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537 → 753
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1439 → 1561
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2085 → 2219
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2668 → 2915
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1911 → 2080
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2449 → 2543
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1684 → 1910
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:2441 → 2444
      Ig; Ig strand A [structural motif]

    6. XM_038002456.1 → XP_037858384.1  kalirin isoform X4

      UniProtKB/TrEMBL
      A0A0D9R5W9
      Conserved Domains (14) summary
      smart00150
      Location:1135 → 1235
      SPEC; Spectrin repeats
      cd11852
      Location:1649 → 1708
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2323 → 2381
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2567 → 2658
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1284 → 1454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537 → 766
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1461 → 1583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2106 → 2240
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2688 → 2935
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1932 → 2101
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2469 → 2563
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1706 → 1931
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:2461 → 2464
      Ig; Ig strand A [structural motif]

    7. XM_038002461.1 → XP_037858389.1  kalirin isoform X10

      UniProtKB/TrEMBL
      A0A0D9R5W9
      Conserved Domains (13) summary
      smart00150
      Location:1135 → 1235
      SPEC; Spectrin repeats
      cd11852
      Location:1649 → 1708
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2325 → 2383
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2569 → 2660
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1284 → 1454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537 → 766
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1461 → 1583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2107 → 2241
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:1933 → 2102
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2471 → 2565
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1706 → 1932
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:2463 → 2466
      Ig; Ig strand A [structural motif]

    8. XM_038002462.1 → XP_037858390.1  kalirin isoform X11

      UniProtKB/TrEMBL
      A0A0D9R5W9
      Conserved Domains (10) summary
      smart00150
      Location:1135 → 1235
      SPEC; Spectrin repeats
      cd11852
      Location:1649 → 1708
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2324 → 2382
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1284 → 1454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537 → 766
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1461 → 1583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2107 → 2241
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:1933 → 2102
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1706 → 1932
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    9. XM_038002463.1 → XP_037858391.1  kalirin isoform X12

      UniProtKB/TrEMBL
      A0A0D9R5W9
      Conserved Domains (10) summary
      smart00150
      Location:1135 → 1235
      SPEC; Spectrin repeats
      cd11852
      Location:1649 → 1708
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2292 → 2350
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1284 → 1454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537 → 766
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1461 → 1583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2075 → 2209
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:1901 → 2070
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1706 → 1845
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    10. XM_038002464.1 → XP_037858392.1  kalirin isoform X13

      UniProtKB/TrEMBL
      A0A0D9R5W9
      Conserved Domains (10) summary
      smart00150
      Location:1126 → 1226
      SPEC; Spectrin repeats
      cd11852
      Location:1640 → 1699
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2282 → 2340
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1275 → 1445
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:891 → 1120
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1452 → 1574
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2065 → 2199
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:1891 → 2060
      RhoGEF; RhoGEF domain
      pfam16609
      Location:1697 → 1835
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    11. XM_007985569.2 → XP_007983760.1  kalirin isoform X14

      See identical proteins and their annotated locations for XP_007983760.1

      Conserved Domains (5) summary
      smart00150
      Location:1135 → 1235
      SPEC; Spectrin repeats
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1284 → 1454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537 → 766
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1461 → 1583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

    12. XM_038002466.1 → XP_037858394.1  kalirin isoform X16

      Conserved Domains (5) summary
      smart00150
      Location:1122 → 1222
      SPEC; Spectrin repeats
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1271 → 1441
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537 → 753
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1448 → 1570
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

    13. XM_038002467.1 → XP_037858395.1  kalirin isoform X17

      Conserved Domains (5) summary
      smart00150
      Location:1113 → 1213
      SPEC; Spectrin repeats
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1262 → 1432
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537 → 753
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1439 → 1561
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

    14. XM_038002465.1 → XP_037858393.1  kalirin isoform X15

      Conserved Domains (5) summary
      smart00150
      Location:1126 → 1226
      SPEC; Spectrin repeats
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1275 → 1445
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:891 → 1120
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1452 → 1574
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

    15. XM_007985554.2 → XP_007983745.2  kalirin isoform X1

      UniProtKB/TrEMBL
      A0A0D9R5W9
      Conserved Domains (14) summary
      smart00150
      Location:1135 → 1235
      SPEC; Spectrin repeats
      cd11852
      Location:1649 → 1708
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2325 → 2383
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2569 → 2660
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1284 → 1454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537 → 766
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1461 → 1583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2107 → 2241
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2690 → 2937
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1933 → 2102
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2471 → 2565
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1706 → 1932
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:2463 → 2466
      Ig; Ig strand A [structural motif]

    16. XM_007985555.2 → XP_007983746.2  kalirin isoform X2

      UniProtKB/TrEMBL
      A0A0D9R5W9
      Conserved Domains (14) summary
      smart00150
      Location:1135 → 1235
      SPEC; Spectrin repeats
      cd11852
      Location:1649 → 1708
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2324 → 2382
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2568 → 2659
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1284 → 1454
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:537 → 766
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1461 → 1583
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2107 → 2241
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2689 → 2936
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1933 → 2102
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2470 → 2564
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1706 → 1932
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:2462 → 2465
      Ig; Ig strand A [structural motif]

    17. XM_007985557.2 → XP_007983748.2  kalirin isoform X5

      UniProtKB/TrEMBL
      A0A0D9R5W9
      Conserved Domains (14) summary
      smart00150
      Location:1126 → 1226
      SPEC; Spectrin repeats
      cd11852
      Location:1640 → 1699
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2316 → 2374
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:39 → 177
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00063
      Location:2560 → 2651
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:1275 → 1445
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:891 → 1120
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1452 → 1574
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2098 → 2232
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:2681 → 2928
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:1924 → 2093
      RhoGEF; RhoGEF domain
      pfam07679
      Location:2462 → 2556
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:1697 → 1923
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:2454 → 2457
      Ig; Ig strand A [structural motif]

    18. XM_007985570.2 → XP_007983761.2  kalirin isoform X18

      Conserved Domains (8) summary
      cd11853
      Location:628 → 686
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd00063
      Location:872 → 963
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd13241
      Location:410 → 544
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:993 → 1240
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:236 → 405
      RhoGEF; RhoGEF domain
      pfam07679
      Location:774 → 868
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:25 → 235
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:766 → 769
      Ig; Ig strand A [structural motif]

    19. XM_038002475.1 → XP_037858403.1  kalirin isoform X26

      Conserved Domains (4) summary
      cd11853
      Location:636 → 694
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd13241
      Location:419 → 553
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:235 → 373
      RhoGEF; RhoGEF domain
      pfam16609
      Location:25 → 234
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    20. XM_038002469.1 → XP_037858397.1  kalirin isoform X20

      Conserved Domains (4) summary
      cd11853
      Location:627 → 685
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd13241
      Location:410 → 544
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:236 → 405
      RhoGEF; RhoGEF domain
      pfam16609
      Location:25 → 235
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    21. XM_038002472.1 → XP_037858400.1  kalirin isoform X23

      Conserved Domains (4) summary
      cd11853
      Location:595 → 653
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd13241
      Location:378 → 512
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:204 → 373
      RhoGEF; RhoGEF domain
      pfam16609
      Location:25 → 148
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    22. XM_038002470.1 → XP_037858398.1  kalirin isoform X21

      Conserved Domains (4) summary
      cd11853
      Location:626 → 684
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd13241
      Location:409 → 543
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:235 → 404
      RhoGEF; RhoGEF domain
      pfam16609
      Location:25 → 234
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    23. XM_038002474.1 → XP_037858402.1  kalirin isoform X25

      Conserved Domains (4) summary
      cd11853
      Location:594 → 652
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd13241
      Location:377 → 511
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:203 → 372
      RhoGEF; RhoGEF domain
      pfam16609
      Location:25 → 147
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    24. XM_038002471.1 → XP_037858399.1  kalirin isoform X22

      Conserved Domains (4) summary
      cd11853
      Location:596 → 654
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd13241
      Location:378 → 512
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:204 → 373
      RhoGEF; RhoGEF domain
      pfam16609
      Location:25 → 148
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    25. XM_038002473.1 → XP_037858401.1  kalirin isoform X24

      Conserved Domains (4) summary
      cd11853
      Location:595 → 653
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd13241
      Location:377 → 511
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:203 → 372
      RhoGEF; RhoGEF domain
      pfam16609
      Location:25 → 147
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    26. XM_038002468.1 → XP_037858396.1  kalirin isoform X19

      Conserved Domains (8) summary
      cd11853
      Location:627 → 685
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd00063
      Location:871 → 962
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd13241
      Location:410 → 544
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14115
      Location:992 → 1239
      STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
      pfam00621
      Location:236 → 405
      RhoGEF; RhoGEF domain
      pfam07679
      Location:773 → 867
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:25 → 235
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:765 → 768
      Ig; Ig strand A [structural motif]
    Nucleotide Protein
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