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    TRM732 tRNA methylation protein TRM732 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855301, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TRM732
    Official Full Name
    tRNA methylation protein TRM732
    Primary source
    SGD:S000004872
    Locus tag
    YMR259C
    See related
    AllianceGenome:SGD:S000004872; FungiDB:YMR259C; VEuPathDB:YMR259C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in wobble position ribose methylation. Located in cytoplasm. Used to study non-syndromic X-linked intellectual disability. Orthologous to human THADA (THADA armadillo repeat containing). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See TRM732 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (784621..788883, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Pet111p Neighboring gene Roy1p Neighboring gene Tif11p Neighboring gene trehalose 6-phosphate synthase/phosphatase complex subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of tRNA methyltransferase complex of Trm7 and Trm734 reveals a novel binding interface for tRNA recognition. Hirata A, et al. Nucleic Acids Res, 2019 Nov 18. PMID 31586407, Free PMC Article
    2. Conservation of an intricate circuit for crucial modifications of the tRNAPhe anticodon loop in eukaryotes. Guy MP, et al. RNA, 2015 Jan. PMID 25404562, Free PMC Article
    3. Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop. Guy MP, et al. RNA, 2012 Oct. PMID 22912484, Free PMC Article
    4. Lack of 2'-O-methylation in the tRNA anticodon loop of two phylogenetically distant yeast species activates the general amino acid control pathway. Han L, et al. PLoS Genet, 2018 Mar. PMID 29596413, Free PMC Article
    5. Systematic bioinformatics and experimental validation of yeast complexes reduces the rate of attrition during structural investigations. Brooks MA, et al. Structure, 2010 Sep 8. PMID 20826334

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop.
      Title: Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wobble position ribose methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wobble position ribose methylation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA methylation protein TRM732
    NP_013986.1
    • Protein involved in 2'-O-methylation of C32 of substrate tRNAs; interacts with 2'-O-ribose methyltransferase Trm7p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene; yeast null mutant can be functionally complemented by human THADA, mutations in which have been implicated in epithelial thyroid adenomas, type 2 diabetes, and polycystic ovary syndrome (PCOS)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      784621..788883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182766.1 → NP_013986.1  TPA: tRNA methylation protein TRM732 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013986.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W085, Q03496, Q04862
      UniProtKB/TrEMBL
      C8ZFC5
      Conserved Domains (2) summary
      COG5543
      Location:1 → 1419
      COG5543; Uncharacterized conserved protein [Function unknown]
      sd00044
      Location:1154 → 1178
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03496.1

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