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    Actr2 actin related protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289820, updated on 27-Nov-2024

    Summary

    Official Symbol
    Actr2provided by RGD
    Official Full Name
    actin related protein 2provided by RGD
    Primary source
    RGD:1310826
    See related
    EnsemblRapid:ENSRNOG00000004959 AllianceGenome:RGD:1310826
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables cytoskeletal protein binding activity. Involved in several processes, including cellular response to trichostatin A; positive regulation of dendritic spine morphogenesis; and response to ethanol. Located in lamellipodium and podosome core. Is active in postsynapse. Orthologous to human ACTR2 (actin related protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 1054.0), Thymus (RPKM 752.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Actr2 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (98500119..98535092, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (94296443..94333735, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (104338486..104375840, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 79 Neighboring gene actin related protein 1A, pseudogene 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120096684 Neighboring gene ribosomal protein S27, pseudogene 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC95085

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytoskeletal protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Arp2/3 complex-mediated actin nucleation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in associative learning IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in asymmetric cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within asymmetric cell division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to trichostatin A IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to type II interferon IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytosolic transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cytosolic transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment or maintenance of cell polarity IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within establishment or maintenance of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within meiotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in meiotic chromosome movement towards spindle pole IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within meiotic chromosome movement towards spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in meiotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within meiotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in regulation of double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in regulation of double-strand break repair via nonhomologous end joining ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to immobilization stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in spindle localization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within spindle localization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Arp2/3 protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Arp2/3 protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in actin cap IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin cap ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in podosome core IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     
    located_in site of double-strand break ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    actin-related protein 2
    Names
    ARP2 actin related protein 2 homolog
    actin-like protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009268.1NP_001009268.1  actin-related protein 2

      See identical proteins and their annotated locations for NP_001009268.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088442
      UniProtKB/Swiss-Prot
      Q5M7U6
      UniProtKB/TrEMBL
      A0A8I6GBC3, A6JQ13
      Related
      ENSRNOP00000006607.5, ENSRNOT00000006607.7
      Conserved Domains (2) summary
      smart00268
      Location:6388
      ACTIN; Actin
      cl17037
      Location:1382
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      98500119..98535092 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)