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    pknK serine/threonine-protein kinase PknK [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 888659, updated on 6-Jun-2024

    Summary

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    Gene symbol
    pknK
    Gene description
    serine/threonine-protein kinase PknK
    Locus tag
    Rv3080c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (3442656..3445988, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene hydroxylaminobenzene mutase Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene HTH-type transcriptional regulator VirS

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mycobacterium tuberculosis protein kinase K enables growth adaptation through translation control. Malhotra V, et al. J Bacteriol, 2012 Aug. PMID 22661693, Free PMC Article
    2. Mycobacterium tuberculosis protein kinase K confers survival advantage during early infection in mice and regulates growth in culture and during persistent infection: implications for immune modulation. Malhotra V, et al. Microbiology (Reading), 2010 Sep. PMID 20522497, Free PMC Article
    3. The Mycobacterium tuberculosis protein kinase K modulates activation of transcription from the promoter of mycobacterial monooxygenase operon through phosphorylation of the transcriptional regulator VirS. Kumar P, et al. J Biol Chem, 2009 Apr 24. PMID 19251699, Free PMC Article
    4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PknK regulates the expression of a large subset of tRNA genes so that regulation is synchronized with growth phase and cellular energy status.
      Title: Mycobacterium tuberculosis protein kinase K enables growth adaptation through translation control.
    2. PknK confers survival advantage during early infection in mice and regulates growth during persistent infection.
      Title: Mycobacterium tuberculosis protein kinase K confers survival advantage during early infection in mice and regulates growth in culture and during persistent infection: implications for immune modulation.
    3. PknK modulates VirS-mediated stimulation of transcription from the mym promoter
      Title: The Mycobacterium tuberculosis protein kinase K modulates activation of transcription from the promoter of mycobacterial monooxygenase operon through phosphorylation of the transcriptional regulator VirS.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PknK
    NP_217596.1
    • protein kinase K (STPK K)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      3442656..3445988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_217596.1 serine/threonine-protein kinase PknK [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_217596.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A9P2HAK4
      Conserved Domains (2) summary
      COG2909
      Location:333 → 1110
      MalT; ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription]
      cd14014
      Location:25 → 284
      STKc_PknB_like; Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WI65.1

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