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    Pdia6 protein disulfide isomerase family A, member 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286906, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pdia6provided by RGD
    Official Full Name
    protein disulfide isomerase family A, member 6provided by RGD
    Primary source
    RGD:628688
    See related
    EnsemblRapid:ENSRNOG00000050197 AllianceGenome:RGD:628688
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    P5; CaBP1; Txndc7
    Summary
    Predicted to enable protein disulfide isomerase activity and protein-disulfide reductase activity. Predicted to be involved in negative regulation of IRE1-mediated unfolded protein response; platelet aggregation; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum lumen and smooth endoplasmic reticulum. Orthologous to human PDIA6 (protein disulfide isomerase family A member 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 1248.9), Kidney (RPKM 732.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pdia6 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (45791704..45808947)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (40062980..40080223)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (42568269..42585654)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479346 Neighboring gene ciliary microtubule inner protein 5 Neighboring gene potassium voltage-gated channel modifier subfamily F member 1 Neighboring gene ATPase H+ transporting V1 subunit C2 Neighboring gene nucleolar protein 10 Neighboring gene craniofacial development protein 1 like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein disulfide isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-disulfide reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of IRE1-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in platelet activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in platelet aggregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein folding TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    part_of endoplasmic reticulum chaperone complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in melanosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in smooth endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein disulfide-isomerase A6
    Names
    calcium-binding protein 1
    protein disulfide isomerase P5
    protein disulfide isomerase associated 6
    protein disulfide isomerase-related protein
    thioredoxin domain containing 7
    thioredoxin domain-containing protein 7
    NP_001004442.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004442.1NP_001004442.1  protein disulfide-isomerase A6 precursor

      See identical proteins and their annotated locations for NP_001004442.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082063
      UniProtKB/Swiss-Prot
      Q63081, Q641Y3
      UniProtKB/TrEMBL
      A6HAU2
      Related
      ENSRNOP00000079392.2, ENSRNOT00000114398.2
      Conserved Domains (2) summary
      cd02983
      Location:280409
      P5_C; P5 family, C-terminal redox inactive TRX-like domain; P5 is a protein disulfide isomerase (PDI)-related protein with a domain structure of aa'b (where a and a' are redox active TRX domains and b is a redox inactive TRX-like domain). Like PDI, P5 is ...
      cd03001
      Location:31133
      PDI_a_P5; PDIa family, P5 subfamily; composed of eukaryotic proteins similar to human P5, a PDI-related protein with a domain structure of aa'b (where a and a' are redox active TRX domains and b is a redox inactive TRX-like domain). Like PDI, P5 is located in the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      45791704..45808947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)