Tmed5 transmembrane p24 trafficking protein 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmed5provided by RGD
Official Full Name: transmembrane p24 trafficking protein 5provided by RGD
Primary source: RGD:1359437
See related: AllianceGenome:RGD:1359437
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LRRG00120
Summary: Predicted to be involved in Golgi ribbon formation; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to be located in cis-Golgi network and endoplasmic reticulum exit site. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human TMED5 (transmembrane p24 trafficking protein 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 320.1), Thymus (RPKM 173.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (1752857..1763990)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (1607895..1619028)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (2613318..2624773)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in Golgi ribbon formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi ribbon formation	IEA Inferred from Electronic Annotation more info
involved_in Golgi ribbon formation	ISO Inferred from Sequence Orthology more info
involved_in Golgi ribbon formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in COPII-coated ER to Golgi transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in cis-Golgi network	IEA Inferred from Electronic Annotation more info
located_in cis-Golgi network	ISO Inferred from Sequence Orthology more info
located_in cis-Golgi network	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum exit site	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum exit site	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum exit site	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum-Golgi intermediate compartment	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane emp24 domain-containing protein 5

Names: p24 family protein gamma-2; p24gamma2; transmembrane emp24 protein transport domain containing 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007619.1 → NP_001007620.1 transmembrane emp24 domain-containing protein 5 precursor

See identical proteins and their annotated locations for NP_001007620.1

Status: PROVISIONAL

Source sequence(s)

BC079452

UniProtKB/Swiss-Prot

Q6AXN3

UniProtKB/TrEMBL

A6KPG8

Conserved Domains (1) summary

pfam01105
Location:35 → 222

EMP24_GP25L; emp24/gp25L/p24 family/GOLD