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    gchfr GTP cyclohydrolase I feedback regulator [ Danio rerio (zebrafish) ]

    Gene ID: 393735, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gchfrprovided by ZNC
    Official Full Name
    GTP cyclohydrolase I feedback regulatorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1731
    See related
    Ensembl:ENSDARG00000098588 AllianceGenome:ZFIN:ZDB-GENE-040426-1731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:73253
    Summary
    Predicted to enable GTP cyclohydrolase binding activity. Predicted to act upstream of or within negative regulation of biosynthetic process. Predicted to be located in cytosol and nuclear membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in liver. Orthologous to human GCHFR (GTP cyclohydrolase I feedback regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See gchfr in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (1063988..1069195)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (860033..865240)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2, regulatory subunit B', gamma a Neighboring gene cytochrome P450, family 1, subfamily C, polypeptide 2 Neighboring gene cdc42 effector protein 3-like Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 17 Neighboring gene inverted formin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. eIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs. Lorenzo-Orts L, et al. EMBO Rep, 2024 Jan. PMID 38177902, Free PMC Article
    2. Evolution of pigment synthesis pathways by gene and genome duplication in fish. Braasch I, et al. BMC Evol Biol, 2007 May 11. PMID 17498288, Free PMC Article
    3. Identification and expression of liver-specific genes after LPS challenge in amphioxus: the hepatic cecum as liver-like organ and "pre-hepatic" acute phase response. Wang Y, et al. Funct Integr Genomics, 2011 Mar. PMID 21052758
    4. HNF factors form a network to regulate liver-enriched genes in zebrafish. Cheng W, et al. Dev Biol, 2006 Jun 15. PMID 16631158
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC73253

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP cyclohydrolase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GTP cyclohydrolase 1 feedback regulatory protein
    Names
    GFRP
    GTP cyclohydrolase I feedback regulatory protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200762.3 → NP_957056.1  GTP cyclohydrolase 1 feedback regulatory protein

      See identical proteins and their annotated locations for NP_957056.1

      Status: VALIDATED

      Source sequence(s)
      EH535515, EH551858
      UniProtKB/Swiss-Prot
      Q6PBT6
      Related
      ENSDARP00000135960.1, ENSDART00000160400.2
      Conserved Domains (1) summary
      pfam06399
      Location:3 → 83
      GFRP; GTP cyclohydrolase I feedback regulatory protein (GFRP)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      1063988..1069195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158967.5 → XP_005159024.1  GTP cyclohydrolase 1 feedback regulatory protein isoform X1

      UniProtKB/TrEMBL
      A0A8M2B5F4
      Conserved Domains (1) summary
      pfam06399
      Location:3 → 82
      GFRP; GTP cyclohydrolase I feedback regulatory protein (GFRP)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PBT6.1 GenPept UniProtKB/Swiss-Prot:Q6PBT6

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