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    marchf6 membrane-associated ring finger (C3HC4) 6 [ Danio rerio (zebrafish) ]

    Gene ID: 100002072, updated on 9-Dec-2024

    Summary

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    Official Symbol
    marchf6provided by ZNC
    Official Full Name
    membrane-associated ring finger (C3HC4) 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-530
    See related
    Ensembl:ENSDARG00000076066 AllianceGenome:ZFIN:ZDB-GENE-070912-530
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    march6; fa98a02; im:7161807; wu:fa98a02; si:dkey-40c17.2
    Summary
    Predicted to enable transferase activity and zinc ion binding activity. Predicted to be involved in ERAD pathway. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 3. Orthologous to human MARCHF6 (membrane associated ring-CH-type finger 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See marchf6 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (30489838..30527330)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (30506267..30543797)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487883 Neighboring gene fATP synthase c subunit lysine N-methyltransferase Neighboring gene ankyrin repeat domain 33Bb Neighboring gene catenin (cadherin-associated protein), delta 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish MARCH7 negatively regulates IFN antiviral response by degrading TBK1. Xiong ST, et al. Int J Biol Macromol, 2023 Jun 15. PMID 37054851
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF6
    NP_001278636.1
    XP_003197917.1
    XP_005163506.1
    XP_005163507.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291707.1 → NP_001278636.1  E3 ubiquitin-protein ligase MARCHF6

      Status: VALIDATED

      Source sequence(s)
      CK024583, CR388419, CT661348, EB899125, EB935699, EB949406, EH451889
      UniProtKB/TrEMBL
      A0A8M1P6Q7, E9QDQ9
      Related
      ENSDARP00000117758.1, ENSDART00000145732.3
      Conserved Domains (1) summary
      smart00744
      Location:9 → 57
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      30489838..30527330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163449.5 → XP_005163506.1  E3 ubiquitin-protein ligase MARCHF6 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BAR2
      Conserved Domains (1) summary
      smart00744
      Location:9 → 57
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    2. XM_005163450.5 → XP_005163507.1  E3 ubiquitin-protein ligase MARCHF6 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BAJ3
      Conserved Domains (1) summary
      smart00744
      Location:9 → 57
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    3. XM_003197869.6 → XP_003197917.1  E3 ubiquitin-protein ligase MARCHF6 isoform X2

      UniProtKB/TrEMBL
      A0A8M1RN76
      Conserved Domains (1) summary
      smart00744
      Location:9 → 57
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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