wnk-1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: wnk-1
Official Full Name: Serine/threonine-protein kinase WNK
Primary source: WormBase:WBGene00006941
Locus tag: CELE_C46C2.1
See related: AllianceGenome:WB:WBGene00006941
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables molecular condensate scaffold activity. Involved in several processes, including cell volume homeostasis; cellular hyperosmotic response; and multicellular organismal-level water homeostasis. Predicted to be active in cytoplasm. Is expressed in body wall musculature; excretory cell; hypodermis; and spermatheca. Used to study pseudohypoaldosteronism. Human ortholog(s) of this gene implicated in Prieto syndrome; hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Orthologous to several human genes including WNK1 (WNK lysine deficient protein kinase 1); WNK2 (WNK lysine deficient protein kinase 2); and WNK3 (WNK lysine deficient protein kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See wnk-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 15

Sequence:: Chromosome: IV; NC_003282.8 (9200103..9212242)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that WNK-1 controls the tubular formation of excretory canals by activating GCK-3, resulting in downregulation of CIC channel activity.
Title: Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.
WNK-1 functions upstream of GCK-3 in a manner similar to that postulated for its mammalian homologs
Title: Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C46C2.1 (e-PCR)
- UniSTS:307341

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables molecular condensate scaffold activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell volume homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular hyperosmotic response	IDA Inferred from Direct Assay more info	PubMed
involved_in hyperosmotic response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hyperosmotic response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in membraneless organelle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in multicellular organismal-level water homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in multicellular organismal-level water homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Serine/threonine-protein kinase WNK

NP_001255368.1

Partially confirmed by transcript evidence

NP_001255369.1

Partially confirmed by transcript evidence

NP_001255370.1

Confirmed by transcript evidence

NP_001255371.1

Confirmed by transcript evidence

NP_001255372.1

Partially confirmed by transcript evidence

NP_001255373.1

Partially confirmed by transcript evidence

NP_001255374.1

Partially confirmed by transcript evidence

NP_001255375.1

Confirmed by transcript evidence

NP_001255376.1

Partially confirmed by transcript evidence

NP_001255377.1

Confirmed by transcript evidence

NP_001294032.1

Partially confirmed by transcript evidence

NP_001294033.1

Partially confirmed by transcript evidence

NP_001294035.1

Confirmed by transcript evidence

NP_001294036.1

Partially confirmed by transcript evidence

NP_001294037.1

Partially confirmed by transcript evidence

NP_001294038.1

Confirmed by transcript evidence

NP_001294039.1

Confirmed by transcript evidence

NP_001294040.1

Confirmed by transcript evidence

NP_001368092.1

Confirmed by transcript evidence

NP_001368454.1

Confirmed by transcript evidence

NP_501603.3

Confirmed by transcript evidence

NP_872075.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

9200103..9212242

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268441.4 → NP_001255370.1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255370.1

Status: REVIEWED

UniProtKB/Swiss-Prot

X5M5N0

Conserved Domains (3) summary

smart00220
Location:335 → 596

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13983
Location:332 → 596

STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

pfam12202
Location:622 → 660

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
NM_001307103.3 → NP_001294032.1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294032.1

Status: REVIEWED

UniProtKB/Swiss-Prot

H2L282, H2L283, H2L284, H2L285, H2L286, H2L288, H2L289, H2L290, H2L291, H2L292, H2L293, Q18657, Q8I127, X5LPT1, X5LPT5, X5LV40, X5LV44, X5LX64, X5M5N0, X5M5N6, X5M8T1, X5M8T5

Conserved Domains (2) summary

cd13983
Location:332 → 596

STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

pfam12202
Location:622 → 686

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
NM_001380400.1 → NP_001368092.1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd13983
Location:330 → 594

STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

pfam12202
Location:620 → 684

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
NM_001307107.3 → NP_001294036.1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294036.1

Status: REVIEWED

UniProtKB/Swiss-Prot

X5M5N0

Conserved Domains (2) summary

cd13983
Location:330 → 594

STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

pfam12202
Location:620 → 684

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
NM_001268439.4 → NP_001255368.1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255368.1

Status: REVIEWED

UniProtKB/Swiss-Prot

X5M5N0

Conserved Domains (3) summary

smart00220
Location:335 → 596

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13983
Location:332 → 596

STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

pfam12202
Location:622 → 660

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
NM_001380399.1 → NP_001368454.1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd13983
Location:332 → 596

STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

pfam12202
Location:622 → 686

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
NM_182275.7 → NP_872075.2 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_872075.2

Status: REVIEWED

UniProtKB/Swiss-Prot

X5M5N0

Conserved Domains (3) summary

smart00220
Location:333 → 594

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13983
Location:330 → 594

STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

pfam12202
Location:620 → 658

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
NM_001307109.4 → NP_001294038.1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294038.1

Status: REVIEWED

UniProtKB/Swiss-Prot

X5M5N0

Conserved Domains (2) summary

cd13983
Location:330 → 594

STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

pfam12202
Location:620 → 684

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
NM_069202.6 → NP_501603.3 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501603.3

Status: REVIEWED

UniProtKB/Swiss-Prot

X5M5N0

Conserved Domains (3) summary

smart00220
Location:333 → 594

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13983
Location:330 → 594

STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

pfam12202
Location:620 → 658

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
NM_001307106.4 → NP_001294035.1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294035.1

Status: REVIEWED

UniProtKB/Swiss-Prot

X5M5N0

Conserved Domains (2) summary

cd13983
Location:332 → 596

STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

pfam12202
Location:622 → 686

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
NM_001307104.3 → NP_001294033.1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294033.1

Status: REVIEWED

UniProtKB/Swiss-Prot

X5M5N0

Conserved Domains (2) summary

cd13983
Location:332 → 596

STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

pfam12202
Location:622 → 686

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
NM_001268443.3 → NP_001255372.1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255372.1

Status: REVIEWED

UniProtKB/Swiss-Prot

X5M5N0

Conserved Domains (3) summary

smart00220
Location:333 → 594

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13983
Location:330 → 594

STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

pfam12202
Location:620 → 658

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
NM_001268442.4 → NP_001255371.1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255371.1

Status: REVIEWED

UniProtKB/Swiss-Prot

X5M5N0

Conserved Domains (3) summary

smart00220
Location:335 → 596

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13983
Location:332 → 596

STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

pfam12202
Location:622 → 660

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
NM_001307108.3 → NP_001294037.1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294037.1

Status: REVIEWED

UniProtKB/Swiss-Prot

X5M5N0

Conserved Domains (2) summary

cd13983
Location:330 → 594

STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

pfam12202
Location:620 → 684

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
NM_001268440.3 → NP_001255369.1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255369.1

Status: REVIEWED

UniProtKB/Swiss-Prot

X5M5N0

Conserved Domains (3) summary

smart00220
Location:335 → 596

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13983
Location:332 → 596

STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

pfam12202
Location:622 → 660

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
NM_001268444.3 → NP_001255373.1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255373.1

Status: REVIEWED

UniProtKB/Swiss-Prot

X5M5N0

Conserved Domains (3) summary

smart00220
Location:333 → 594

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13983
Location:330 → 594

STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

pfam12202
Location:620 → 658

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
NM_001268445.3 → NP_001255374.1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255374.1

Status: REVIEWED

UniProtKB/Swiss-Prot

X5M5N0

Conserved Domains (3) summary

smart00220
Location:282 → 543

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13983
Location:279 → 543

STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

pfam12202
Location:569 → 607

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
NM_001268446.3 → NP_001255375.1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255375.1

Status: REVIEWED

UniProtKB/Swiss-Prot

X5M5N0

Conserved Domains (3) summary

smart00220
Location:282 → 543

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13983
Location:279 → 543

STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

pfam12202
Location:569 → 607

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
NM_001268447.3 → NP_001255376.1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255376.1

Status: REVIEWED

UniProtKB/Swiss-Prot

X5M5N0

Conserved Domains (3) summary

smart00220
Location:280 → 541

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13983
Location:277 → 541

STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

pfam12202
Location:567 → 605

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
NM_001268448.3 → NP_001255377.1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255377.1

Status: REVIEWED

UniProtKB/Swiss-Prot

X5M5N0

Conserved Domains (3) summary

smart00220
Location:280 → 541

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13983
Location:277 → 541

STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

pfam12202
Location:567 → 605

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
NM_001307111.4 → NP_001294040.1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294040.1

Status: REVIEWED

UniProtKB/Swiss-Prot

X5M5N0
NM_001307110.3 → NP_001294039.1 Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294039.1

Status: REVIEWED

UniProtKB/Swiss-Prot

X5M5N0