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    katnb1 katanin p80 (WD repeat containing) subunit B 1 [ Danio rerio (zebrafish) ]

    Gene ID: 406291, updated on 9-Dec-2024

    Summary

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    Official Symbol
    katnb1provided by ZNC
    Official Full Name
    katanin p80 (WD repeat containing) subunit B 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1954
    See related
    Ensembl:ENSDARG00000005456 AllianceGenome:ZFIN:ZDB-GENE-040426-1954
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56071; wu:fj32f02; wu:fj65h01
    Summary
    Predicted to enable microtubule binding activity. Acts upstream of or within midbrain development. Predicted to be located in cytoplasm and spindle pole. Predicted to be part of katanin complex. Is expressed in brain; oocyte; and pectoral fin. Used to study idiopathic scoliosis. Human ortholog(s) of this gene implicated in lissencephaly 6. Orthologous to human KATNB1 (katanin regulatory subunit B1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See katnb1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (52158833..52285337)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (51883729..52010276)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene si:dkey-286h2.5 Neighboring gene transmembrane protein 208 Neighboring gene solute carrier organic anion transporter family member 3A1b Neighboring gene uncharacterized LOC103911423

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mutations in KATNB1 cause complex cerebral malformations by disrupting asymmetrically dividing neural progenitors. Mishra-Gorur K, et al. Neuron, 2014 Dec 17. PMID 25521378, Free PMC Article
    2. Characterization of Ambra1 in asexual cycle of a non-vertebrate chordate, the colonial tunicate Botryllus schlosseri, and phylogenetic analysis of the protein group in Bilateria. Gasparini F, et al. Mol Phylogenet Evol, 2016 Feb. PMID 26611831
    3. Resolving primary pathomechanisms driving idiopathic-like spinal curvature using a new katnb1 scoliosis model. Meyer-Miner A, et al. iScience, 2022 Sep 16. PMID 36105588, Free PMC Article
    4. Katanin p80 regulates human cortical development by limiting centriole and cilia number. Hu WF, et al. Neuron, 2014 Dec 17. PMID 25521379, Free PMC Article
    5. Sinhcaf-dependent histone deacetylation is essential for primordial germ cell specification. Tao B, et al. EMBO Rep, 2022 Jun 7. PMID 35532311, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule severing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule severing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within midbrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of katanin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of katanin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    katanin p80 WD40 repeat-containing subunit B1
    Names
    katanin p80 WD40-containing subunit B1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213018.1 → NP_998183.1  katanin p80 WD40 repeat-containing subunit B1

      See identical proteins and their annotated locations for NP_998183.1

      Status: PROVISIONAL

      Source sequence(s)
      BC047819
      UniProtKB/Swiss-Prot
      Q7ZUV2
      Related
      ENSDARP00000024623.7, ENSDART00000014632.10
      Conserved Domains (5) summary
      COG2319
      Location:3 → 295
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:13 → 292
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05104
      Location:346 → 476
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
      pfam13925
      Location:535 → 686
      Katanin_con80; con80 domain of Katanin
      sd00039
      Location:67 → 103
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      52158833..52285337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166504.5 → XP_005166561.1  katanin p80 WD40 repeat-containing subunit B1 isoform X1

      See identical proteins and their annotated locations for XP_005166561.1

      UniProtKB/Swiss-Prot
      Q7ZUV2
      Conserved Domains (5) summary
      COG2319
      Location:3 → 295
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:13 → 292
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05104
      Location:346 → 476
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
      pfam13925
      Location:535 → 686
      Katanin_con80; con80 domain of Katanin
      sd00039
      Location:67 → 103
      7WD40; WD40 repeat [structural motif]

    2. XM_068222209.1 → XP_068078310.1  katanin p80 WD40 repeat-containing subunit B1 isoform X2

    3. XM_068222210.1 → XP_068078311.1  katanin p80 WD40 repeat-containing subunit B1 isoform X3

    4. XM_005166505.5 → XP_005166562.1  katanin p80 WD40 repeat-containing subunit B1 isoform X1

      See identical proteins and their annotated locations for XP_005166562.1

      UniProtKB/Swiss-Prot
      Q7ZUV2
      Conserved Domains (5) summary
      COG2319
      Location:3 → 295
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:13 → 292
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05104
      Location:346 → 476
      Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
      pfam13925
      Location:535 → 686
      Katanin_con80; con80 domain of Katanin
      sd00039
      Location:67 → 103
      7WD40; WD40 repeat [structural motif]

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394711.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      187803..207436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395268.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      91571..117794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZUV2.1 GenPept UniProtKB/Swiss-Prot:Q7ZUV2

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