guca1d guanylate cyclase activator 1d [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: guca1dprovided by ZNC
Official Full Name: guanylate cyclase activator 1dprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040724-231
See related: Ensembl:ENSDARG00000044629 AllianceGenome:ZFIN:ZDB-GENE-040724-231
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gcap4; si:rp71-1p14.1
Summary: Enables calcium ion binding activity and calcium sensitive guanylate cyclase activator activity. Predicted to be involved in regulation of signal transduction. Is expressed in eye; retina; retinal cone cell; and retinal outer nuclear layer. Orthologous to human GUCA1C (guanylate cyclase activator 1C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (22906581..22910436, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (22869976..22873831, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that high guanylate cyclase activities in larval eye preparations and the precisely controlled coexpression of guanylate cyclases and GCAPs 3, 4, and 7 coincide with the onset of visual function at 3-4 days post fertilization.
Title: Expression profiles of three novel sensory guanylate cyclases and guanylate cyclase-activating proteins in the zebrafish retina.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables calcium sensitive guanylate cyclase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium sensitive guanylate cyclase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: guanylate cyclase activator 1d

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011661.1 → NP_001011661.1 guanylate cyclase activator 1d

See identical proteins and their annotated locations for NP_001011661.1

Status: PROVISIONAL

Source sequence(s)

AY850384

UniProtKB/TrEMBL

A0A2R8QGL2, F6NXK0, Q5MAC9, Q6ZM98

Related

ENSDARP00000065566.4, ENSDART00000065567.5

Conserved Domains (3) summary

cd00051
Location:89 → 157

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:90 → 154

EF-hand_7; EF-hand domain pair

pfam13833
Location:28 → 76

EF-hand_8; EF-hand domain pair