CYSC1 cysteine synthase C1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CYSC1
Official Full Name: cysteine synthase C1
Primary source: TAIR:AT3G61440
Locus tag: AT3G61440
See related: Araport:AT3G61440
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARATH;BSAS3;1; ATCYSC1; BETA-SUBSTITUTED ALA SYNTHASE 3;1; CYSTEINE SYNTHASE; cysteine synthase C1; CYSTEINE SYNTHASE C1
Summary: Encodes a cysteine synthase isomer CysC1. The isomer is however less effective in cysteine biosynthesis. It is involved in beta-cyanoalanine biosynthesis, an intermediate of cyanide detoxification pathway.
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Genomic context

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See CYSC1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 10

Sequence:: Chromosome: 3; NC_003074.8 (22735663..22738131)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of cyanoalanine synthase and alternative oxidase in promoting salt stress tolerance in Arabidopsis thaliana.
Title: The role of cyanoalanine synthase and alternative oxidase in promoting salt stress tolerance in Arabidopsis thaliana.
Genetic crosses between the cas-c1 mutant and scn1 or rhd2 mutants were performed, and the detailed phenotypic and molecular characterization of the double mutants demonstrates that scn1 mutation is epistatic to cas-c1 and cas-c1 is epistatic to rhd2 mutation, indicating that CAS-C1 acts in early steps of the root hair development process.[CAS-C1]
Title: ß-Cyanoalanine Synthase Action in Root Hair Elongation is Exerted at Early Steps of the Root Hair Elongation Pathway and is Independent of Direct Cyanide Inactivation of NADPH Oxidase.
essential for maintaining non-toxic concentrations of cyanide in mitochondria to facilitate cyanide's role in signaling
Title: Beyond toxicity: a regulatory role for mitochondrial cyanide.
the regulation of CYSC1 gene in the plant immune response to pathogen attack
Title: Transient transcriptional regulation of the CYS-C1 gene and cyanide accumulation upon pathogen infection in the plant immune response.
The cys-c1 knockout mutant has altered root hair development.
Title: Mitochondrial beta-cyanoalanine synthase is essential for root hair formation in Arabidopsis thaliana.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001084855.2

Supported by ESTs:

NM_001203223.1

Supported by ESTs:

NM_001340099.1

Supported by ESTs:

NM_116009.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables L-3-cyanoalanine synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-3-cyanoalanine synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables copper ion binding	HDA more info	PubMed
enables cysteine synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cysteine synthase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cyanide catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cyanide metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cysteine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cysteine biosynthetic process from serine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within detoxification of nitrogen compound	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root hair cell development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cysteine synthase C1

NP_001078324.1

CYSTEINE SYNTHASE C1 (ATCYSC1); FUNCTIONS IN: cysteine synthase activity, copper ion binding, L-3-cyanoalanine synthase activity; INVOLVED IN: cysteine biosynthetic process, detoxification of nitrogen compound, cyanide metabolic process; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent enzyme, beta subunit (InterPro:IPR001926), Cysteine synthase A (InterPro:IPR005859); BEST Arabidopsis thaliana protein match is: O-acetylserine (thiol) lyase isoform C (TAIR:AT3G59760.1); Has 18552 Blast hits to 18542 proteins in 2624 species: Archae - 313; Bacteria - 12869; Metazoa - 388; Fungi - 549; Plants - 552; Viruses - 2; Other Eukaryotes - 3879 (source: NCBI BLink).

NP_001190152.1

cysteine synthase C1 (CYSC1); CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent enzyme, beta subunit (InterPro:IPR001926); BEST Arabidopsis thaliana protein match is: O-acetylserine (thiol) lyase isoform C (TAIR:AT3G59760.3).

NP_191703.1

cysteine synthase C1 (CYSC1); FUNCTIONS IN: cysteine synthase activity, copper ion binding, L-3-cyanoalanine synthase activity; INVOLVED IN: cysteine biosynthetic process, detoxification of nitrogen compound, cyanide metabolic process; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site (InterPro:IPR001216), Cysteine synthase A (InterPro:IPR005859), Pyridoxal phosphate-dependent enzyme, beta subunit (InterPro:IPR001926), Cysteine synthase K/M (InterPro:IPR005856); BEST Arabidopsis thaliana protein match is: O-acetylserine (thiol) lyase isoform C (TAIR:AT3G59760.3); Has 22016 Blast hits to 21996 proteins in 2681 species: Archae - 390; Bacteria - 15417; Metazoa - 417; Fungi - 652; Plants - 575; Viruses - 2; Other Eukaryotes - 4563 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

22735663..22738131

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001203223.1 → NP_001190152.1 cysteine synthase C1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190152.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9S757

Conserved Domains (1) summary

cl00342
Location:1 → 247

Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
NM_116009.4 → NP_191703.1 cysteine synthase C1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_191703.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4JEA0, F4JEA1, Q9S757

UniProtKB/TrEMBL

A0A178VGN1, A0A5S9XPI6

Conserved Domains (1) summary

PLN02556
Location:1 → 368

PLN02556; cysteine synthase/L-3-cyanoalanine synthase
NM_001340099.1 → NP_001327883.1 cysteine synthase C1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LTP2, A0A5S9XPI6
NM_001084855.2 → NP_001078324.1 cysteine synthase C1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001078324.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9S757

Conserved Domains (1) summary

cl00342
Location:1 → 272

Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...