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    Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25450, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gabrb1provided by RGD
    Official Full Name
    gamma-aminobutyric acid type A receptor subunit beta1provided by RGD
    Primary source
    RGD:2649
    See related
    EnsemblRapid:ENSRNOG00000002327 AllianceGenome:RGD:2649
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GARB1
    Summary
    Enables GABA receptor binding activity; GABA-A receptor activity; and monoatomic ion channel activity. Involved in several processes, including cellular response to histamine; central nervous system neuron development; and response to progesterone. Located in dendrite; nuclear envelope; and plasma membrane. Part of GABA-A receptor complex. Is active in GABA-ergic synapse; postsynaptic specialization membrane; and presynaptic active zone membrane. Biomarker of hepatic encephalopathy. Human ortholog(s) of this gene implicated in autistic disorder and developmental and epileptic encephalopathy 45. Orthologous to human GABRB1 (gamma-aminobutyric acid type A receptor subunit beta1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 172.6) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gabrb1 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (36434339..36917920, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (36068725..36548946, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (38631192..39112598, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene myosin light chain 6, pseudogene 3 Neighboring gene COMM domain containing 8 Neighboring gene uncharacterized LOC120096598 Neighboring gene olfactory receptor family 6 subfamily C member 66G, pseudogene 1 Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha 4 Neighboring gene cytochrome c oxidase subunit 7B2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    enables GABA receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables GABA-A receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GABA-A receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GABA-A receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables GABA-A receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GABA-gated chloride ion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GABA-gated chloride ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ligand-gated monoatomic ion channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ligand-gated monoatomic ion channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    enables monoatomic anion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential EXP
    Inferred from Experiment
    more info
    PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of GABA-A receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of GABA-A receptor complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of GABA-A receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in GABA-ergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    gamma-aminobutyric acid receptor subunit beta-1
    Names
    GABA(A) receptor subunit beta-1
    GABAAR subunit beta-1
    Gamma-aminobutyric acid receptor beta 1
    gamma-aminobutyric acid (GABA) A receptor, beta 1
    gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1
    gamma-aminobutyric acid type A receptor beta 1 subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012956.2NP_037088.1  gamma-aminobutyric acid receptor subunit beta-1 precursor

      See identical proteins and their annotated locations for NP_037088.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P15431
      UniProtKB/TrEMBL
      A6JD82
      Related
      ENSRNOP00000003170.5, ENSRNOT00000003170.5
      Conserved Domains (1) summary
      TIGR00860
      Location:9472
      LIC; Cation transporter family protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      36434339..36917920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272872.1XP_063128942.1  gamma-aminobutyric acid receptor subunit beta-1 isoform X1

    2. XM_063272873.1XP_063128943.1  gamma-aminobutyric acid receptor subunit beta-1 isoform X1

    3. XM_063272871.1XP_063128941.1  gamma-aminobutyric acid receptor subunit beta-1 isoform X1

    4. XM_063272874.1XP_063128944.1  gamma-aminobutyric acid receptor subunit beta-1 isoform X2