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    Sh3glb2 SH3-domain GRB2-like endophilin B2 [ Mus musculus (house mouse) ]

    Gene ID: 227700, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sh3glb2provided by MGI
    Official Full Name
    SH3-domain GRB2-like endophilin B2provided by MGI
    Primary source
    MGI:MGI:2385131
    See related
    Ensembl:ENSMUSG00000026860 AllianceGenome:MGI:2385131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SPAS-1
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in membrane organization and postsynaptic neurotransmitter receptor internalization. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in glutamatergic synapse; membrane; and postsynaptic endocytic zone. Is expressed in several structures, including central nervous system; dorsal root ganglion; eye; limb; and skeleton. Orthologous to human SH3GLB2 (SH3 domain containing GRB2 like, endophilin B2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 61.1), frontal lobe adult (RPKM 59.8) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Sh3glb2 in Genome Data Viewer
    Location:
    2 B; 2 21.6 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30234789..30249380, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30344777..30359358, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7805 Neighboring gene nucleoporin 188 Neighboring gene dolichol kinase Neighboring gene predicted gene, 39780 Neighboring gene mitoguardin 2 Neighboring gene STARR-positive B cell enhancer ABC_E410 Neighboring gene dolichyl pyrophosphate phosphatase 1 Neighboring gene carnitine acetyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • KIAA1848

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in postsynaptic neurotransmitter receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic endocytic zone ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    endophilin-B2
    Names
    SH3 domain-containing GRB2-like protein B2
    SH3-containing protein SH3GLB2
    stimulator of prostatic adenocarcinoma-specific T-cells-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289709.1NP_001276638.1  endophilin-B2 isoform 1

      See identical proteins and their annotated locations for NP_001276638.1

      Status: VALIDATED

      Source sequence(s)
      AK152409, BY317126, BY651947, CB249880, CX216029, EF676083
      Consensus CDS
      CCDS71020.1
      UniProtKB/Swiss-Prot
      Q3TIQ1, Q3U2J4, Q3U824, Q8K140, Q8R3V5, Q91ZI7
      UniProtKB/TrEMBL
      B0LDS3
      Related
      ENSMUSP00000097788.5, ENSMUST00000100215.11
      Conserved Domains (2) summary
      cd07617
      Location:21278
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
      cd11944
      Location:344398
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    2. NM_001289710.1NP_001276639.1  endophilin-B2 isoform 3

      See identical proteins and their annotated locations for NP_001276639.1

      Status: VALIDATED

      Source sequence(s)
      AK152502, BY317126, BY651947, CX216029
      Consensus CDS
      CCDS71018.1
      UniProtKB/TrEMBL
      A2AWI9, B0LDS3
      Related
      ENSMUSP00000109250.4, ENSMUST00000113620.10
      Conserved Domains (2) summary
      cd07617
      Location:21257
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
      cd11944
      Location:318372
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    3. NM_001346806.2NP_001333735.1  endophilin-B2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL954388
      Consensus CDS
      CCDS84504.1
      UniProtKB/TrEMBL
      A2AWI7, B0LDS3
      Related
      ENSMUSP00000109251.4, ENSMUST00000113621.10
    4. NM_001362888.1NP_001349817.1  endophilin-B2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL954388
      UniProtKB/TrEMBL
      B0LDS3
      Conserved Domains (2) summary
      cd07617
      Location:21249
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
      cd11944
      Location:310364
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    5. NM_139302.2NP_647463.1  endophilin-B2 isoform 2

      See identical proteins and their annotated locations for NP_647463.1

      Status: VALIDATED

      Source sequence(s)
      AK152409, BY317126, BY651947, CX216029, EF676083
      Consensus CDS
      CCDS15879.1
      UniProtKB/TrEMBL
      B0LDS3
      Related
      ENSMUSP00000028214.9, ENSMUST00000028214.15
      Conserved Domains (2) summary
      cd07617
      Location:21278
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
      cd11944
      Location:339393
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

    RNA

    1. NR_156413.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL954388

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      30234789..30249380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160832.1XP_036016725.1  endophilin-B2 isoform X8

      Conserved Domains (2) summary
      cd11944
      Location:247301
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:1181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_036160841.1XP_036016734.1  endophilin-B2 isoform X11

      Conserved Domains (1) summary
      cl12013
      Location:1181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    3. XM_006497939.2XP_006498002.1  endophilin-B2 isoform X3

      UniProtKB/TrEMBL
      B0LDS3
      Related
      ENSMUSP00000131545.3, ENSMUST00000163668.3
      Conserved Domains (2) summary
      cd07617
      Location:21257
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
      cd11944
      Location:323377
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    4. XM_030249870.1XP_030105730.1  endophilin-B2 isoform X6

      Conserved Domains (1) summary
      cd07617
      Location:21278
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
    5. XM_006497938.2XP_006498001.1  endophilin-B2 isoform X2

      UniProtKB/TrEMBL
      B0LDS3
      Conserved Domains (2) summary
      cd07617
      Location:21261
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
      cd11944
      Location:327381
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    6. XM_006497937.2XP_006498000.1  endophilin-B2 isoform X1

      UniProtKB/TrEMBL
      B0LDS3
      Conserved Domains (2) summary
      cd07617
      Location:21282
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
      cd11944
      Location:343397
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    7. XM_011239078.2XP_011237380.1  endophilin-B2 isoform X5

      Conserved Domains (1) summary
      cd07617
      Location:21282
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
    8. XM_011239077.2XP_011237379.1  endophilin-B2 isoform X4

      Conserved Domains (1) summary
      cd07617
      Location:21282
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
    9. XM_006497941.5XP_006498004.1  endophilin-B2 isoform X7

      See identical proteins and their annotated locations for XP_006498004.1

      Conserved Domains (2) summary
      cd11944
      Location:251305
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:1185
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    10. XM_030249882.1XP_030105742.1  endophilin-B2 isoform X10

      Conserved Domains (2) summary
      cd11944
      Location:226280
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:1160
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    11. XM_030249878.1XP_030105738.1  endophilin-B2 isoform X9

      Conserved Domains (2) summary
      cd11944
      Location:242296
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:1181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    12. XM_006497942.4XP_006498005.1  endophilin-B2 isoform X7

      See identical proteins and their annotated locations for XP_006498005.1

      Conserved Domains (2) summary
      cd11944
      Location:251305
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:1185
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    13. XM_036160844.1XP_036016737.1  endophilin-B2 isoform X13

      Conserved Domains (2) summary
      cd11944
      Location:159213
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:3698
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    14. XM_036160842.1XP_036016735.1  endophilin-B2 isoform X12

      Conserved Domains (2) summary
      cd11944
      Location:164218
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:3698
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    15. XM_030249884.1XP_030105744.1  endophilin-B2 isoform X12

      Conserved Domains (2) summary
      cd11944
      Location:164218
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:3698
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_004939601.1 RNA Sequence