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    Tlr8 toll-like receptor 8 [ Mus musculus (house mouse) ]

    Gene ID: 170744, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tlr8provided by MGI
    Official Full Name
    toll-like receptor 8provided by MGI
    Primary source
    MGI:MGI:2176887
    See related
    Ensembl:ENSMUSG00000040522 AllianceGenome:MGI:2176887
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable identical protein binding activity; nucleic acid binding activity; and pattern recognition receptor activity. Acts upstream of or within regulation of protein phosphorylation. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Is expressed in brain and liver. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TLR8 (toll like receptor 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See Tlr8 in Genome Data Viewer
    Location:
    X F5; X 78.29 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (166024119..166047325, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (167241123..167264329, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39549 Neighboring gene STARR-seq mESC enhancer starr_48267 Neighboring gene thymosin, beta 4, X chromosome Neighboring gene STARR-seq mESC enhancer starr_48268 Neighboring gene STARR-seq mESC enhancer starr_48270 Neighboring gene toll-like receptor 7 Neighboring gene STARR-positive B cell enhancer mm9_chrX:163766615-163766916 Neighboring gene STARR-seq mESC enhancer starr_48272 Neighboring gene STARR-seq mESC enhancer starr_48273 Neighboring gene STARR-seq mESC enhancer starr_48274 Neighboring gene phosphoribosyl pyrophosphate synthetase 2 Neighboring gene predicted gene 15239 Neighboring gene predicted gene, 26368

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pattern recognition receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of interleukin-12 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of interleukin-12 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interferon-alpha production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-alpha production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-1 beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-6 production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-8 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type II interferon production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in toll-like receptor 8 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in toll-like receptor 8 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in toll-like receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313760.1NP_001300689.1  toll-like receptor 8 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL731735, BC132054, BY210507
      UniProtKB/Swiss-Prot
      P58682
      Conserved Domains (5) summary
      PRK15370
      Location:47231
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      smart00255
      Location:8681004
      TIR; Toll - interleukin 1 - resistance
      PLN00113
      Location:141717
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:6285
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:701762
      LRR_8; Leucine rich repeat
    2. NM_001313761.1NP_001300690.1  toll-like receptor 8 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region and an alternate segment in the 3' end compared to variant 1. The transcript uses a downstream start codon compared to variant 1, resulting in an isoform (3) that is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL731735, BC132054, BY203258
      UniProtKB/Swiss-Prot
      P58682
      Conserved Domains (4) summary
      smart00255
      Location:352488
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:27246
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:427
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:81148
      LRR_8; Leucine rich repeat
    3. NM_133212.3NP_573475.2  toll-like receptor 8 isoform 1 precursor

      See identical proteins and their annotated locations for NP_573475.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL731735, BC132054, BY203208
      Consensus CDS
      CCDS41209.1
      UniProtKB/Swiss-Prot
      A2AHI9, P58682, Q91XI7
      Related
      ENSMUSP00000107793.2, ENSMUST00000112170.2
      Conserved Domains (4) summary
      smart00255
      Location:8711007
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:32252
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:6588
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:600667
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      166024119..166047325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528719.4XP_006528782.1  toll-like receptor 8 isoform X1

      See identical proteins and their annotated locations for XP_006528782.1

      Conserved Domains (5) summary
      PRK15370
      Location:47231
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      smart00255
      Location:8681004
      TIR; Toll - interleukin 1 - resistance
      PLN00113
      Location:141717
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:6285
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:701762
      LRR_8; Leucine rich repeat
    2. XM_017318405.2XP_017173894.1  toll-like receptor 8 isoform X1

      Conserved Domains (5) summary
      PRK15370
      Location:47231
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      smart00255
      Location:8681004
      TIR; Toll - interleukin 1 - resistance
      PLN00113
      Location:141717
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:6285
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:701762
      LRR_8; Leucine rich repeat