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    Kat6b K(lysine) acetyltransferase 6B [ Mus musculus (house mouse) ]

    Gene ID: 54169, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kat6bprovided by MGI
    Official Full Name
    K(lysine) acetyltransferase 6Bprovided by MGI
    Primary source
    MGI:MGI:1858746
    See related
    Ensembl:ENSMUSG00000021767 AllianceGenome:MGI:1858746
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    qkf; Morf; Myst4; MYST-4; querkopf; mKIAA0383; B130044K16Rik
    Summary
    Enables histone acetyltransferase activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in chromatin. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; facial prominence; genitourinary system; and limb mesenchyme. Used to study Noonan syndrome. Human ortholog(s) of this gene implicated in Ohdo syndrome, SBBYS variant; bipolar disorder; breast cancer; and leiomyoma. Orthologous to human KAT6B (lysine acetyltransferase 6B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 5.4), frontal lobe adult (RPKM 5.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kat6b in Genome Data Viewer
    Location:
    14 A3; 14 11.73 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (21549284..21722546)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (21499216..21672478)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36127 Neighboring gene adenosine kinase Neighboring gene VISTA enhancer mm1738 Neighboring gene STARR-seq mESC enhancer starr_36134 Neighboring gene predicted gene, 30363 Neighboring gene STARR-positive B cell enhancer ABC_E8945 Neighboring gene STARR-positive B cell enhancer ABC_E605 Neighboring gene STARR-positive B cell enhancer ABC_E4100 Neighboring gene STARR-seq mESC enhancer starr_36143 Neighboring gene STARR-seq mESC enhancer starr_36148 Neighboring gene VISTA enhancer mm1600 Neighboring gene dual specificity phosphatase 29 Neighboring gene dual specificity phosphatase 13B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 
    • Gene trapped (1)  1 citation
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H2AK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AK9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BK12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H3K122 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K14 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K14 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3K18 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K23 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K27 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K36 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K4 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K56 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4K12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4K16 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4K5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4K8 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide-lysine-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide-lysine-N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of MOZ/MORF histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MOZ/MORF histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    histone acetyltransferase KAT6B
    Names
    MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4
    MYST histone acetyltransferase monocytic leukemia 4
    histone acetyltransferase MYST4
    histone acetyltransferase querkopf
    monocytic leukemia
    protein querkopf
    NP_001192170.1
    NP_001395624.1
    NP_001395625.1
    NP_059507.2
    XP_006519326.1
    XP_006519327.1
    XP_006519328.1
    XP_006519332.1
    XP_017171571.1
    XP_017171573.1
    XP_030103747.1
    XP_030103748.1
    XP_036014649.1
    XP_036014650.1
    XP_036014651.1
    XP_036014652.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205241.2NP_001192170.1  histone acetyltransferase KAT6B isoform 1

      See identical proteins and their annotated locations for NP_001192170.1

      Status: VALIDATED

      Source sequence(s)
      AC115122, AC148978
      Consensus CDS
      CCDS59615.1
      UniProtKB/TrEMBL
      Q3UH94
      Related
      ENSMUSP00000138511.2, ENSMUST00000182855.8
      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:430698
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:213271
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
    2. NM_001408695.1NP_001395624.1  histone acetyltransferase KAT6B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC115122, AC148978
      UniProtKB/TrEMBL
      Q3UH94
    3. NM_001408696.1NP_001395625.1  histone acetyltransferase KAT6B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115122, AC148978
      UniProtKB/Swiss-Prot
      E9QK86, Q7TNW5, Q8BG35, Q8BRB7, Q8C441, Q9JKX5
      UniProtKB/TrEMBL
      Q3UH94
      Related
      ENSMUSP00000138421.2, ENSMUST00000182964.3
    4. NM_017479.4NP_059507.2  histone acetyltransferase KAT6B isoform 1

      See identical proteins and their annotated locations for NP_059507.2

      Status: VALIDATED

      Source sequence(s)
      AC115122, AC148978
      Consensus CDS
      CCDS59615.1
      UniProtKB/TrEMBL
      Q3UH94
      Related
      ENSMUSP00000138377.2, ENSMUST00000182405.9
      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:430698
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:213271
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      21549284..21722546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519265.5XP_006519328.1  histone acetyltransferase KAT6B isoform X1

      See identical proteins and their annotated locations for XP_006519328.1

      UniProtKB/TrEMBL
      A0A5F8MQ39, Q3UH94
      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    2. XM_036158758.1XP_036014651.1  histone acetyltransferase KAT6B isoform X6

      UniProtKB/TrEMBL
      Q3UH94
      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:430698
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:213271
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
    3. XM_006519264.5XP_006519327.1  histone acetyltransferase KAT6B isoform X1

      See identical proteins and their annotated locations for XP_006519327.1

      UniProtKB/TrEMBL
      A0A5F8MQ39, Q3UH94
      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    4. XM_036158756.1XP_036014649.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/TrEMBL
      A0A5F8MQ39, Q3UH94
      Related
      ENSMUSP00000159058.2, ENSMUST00000238837.2
      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    5. XM_036158759.1XP_036014652.1  histone acetyltransferase KAT6B isoform X7

      UniProtKB/TrEMBL
      Q3UH94
      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:367635
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272310
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:213271
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
    6. XM_030247887.2XP_030103747.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/TrEMBL
      A0A5F8MQ39, Q3UH94
      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    7. XM_017316082.3XP_017171571.1  histone acetyltransferase KAT6B isoform X2

      UniProtKB/TrEMBL
      Q3UH94
      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    8. XM_006519263.5XP_006519326.1  histone acetyltransferase KAT6B isoform X1

      See identical proteins and their annotated locations for XP_006519326.1

      UniProtKB/TrEMBL
      A0A5F8MQ39, Q3UH94
      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    9. XM_036158757.1XP_036014650.1  histone acetyltransferase KAT6B isoform X3

      UniProtKB/TrEMBL
      Q3UH94
      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:584852
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    10. XM_017316084.3XP_017171573.1  histone acetyltransferase KAT6B isoform X7

      UniProtKB/TrEMBL
      Q3UH94
      Conserved Domains (4) summary
      smart00526
      Location:94168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:367635
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272310
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:213271
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
    11. XM_006519269.5XP_006519332.1  histone acetyltransferase KAT6B isoform X5

      UniProtKB/TrEMBL
      Q3UH94
      Conserved Domains (2) summary
      PLN00104
      Location:436704
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:133
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    12. XM_030247888.2XP_030103748.1  histone acetyltransferase KAT6B isoform X8

      Conserved Domains (1) summary
      PLN00104
      Location:557
      PLN00104; MYST -like histone acetyltransferase; Provisional