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    Ano8 anoctamin 8 [ Mus musculus (house mouse) ]

    Gene ID: 382014, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ano8provided by MGI
    Official Full Name
    anoctamin 8provided by MGI
    Primary source
    MGI:MGI:2687327
    See related
    Ensembl:ENSMUSG00000034863 AllianceGenome:MGI:2687327
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem16h
    Summary
    Predicted to enable intracellularly calcium-gated chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; head mesenchyme; sensory organ; and viscerocranium. Orthologous to human ANO8 (anoctamin 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 36.0), CNS E14 (RPKM 35.1) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ano8 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.43 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71928660..71938735, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71476016..71486092, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E6651 Neighboring gene STARR-positive B cell enhancer ABC_E358 Neighboring gene mitochondrial ribosomal protein L34 Neighboring gene DET1 and DDB1 associated 1 Neighboring gene STARR-positive B cell enhancer ABC_E2868 Neighboring gene GTP binding protein 3 Neighboring gene plasmalemma vesicle associated protein Neighboring gene coiled-coil domain containing 194 Neighboring gene 14-3-3 protein sigma-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of TMEM16H gene in silico. Katoh M, et al. Int J Mol Med, 2005 Feb. PMID 15647853
    2. Expression patterns of the Tmem16 gene family during cephalic development in the mouse. Gritli-Linde A, et al. Gene Expr Patterns, 2009 Mar. PMID 19059364
    3. Expression of TMEM16 paralogs during murine embryogenesis. Rock JR, et al. Dev Dyn, 2008 Sep. PMID 18729231
    4. Expression and function of epithelial anoctamins. Schreiber R, et al. J Biol Chem, 2010 Mar 5. PMID 20056604, Free PMC Article
    5. Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. Suzuki J, et al. J Biol Chem, 2013 May 10. PMID 23532839, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables intracellularly calcium-gated chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables intracellularly calcium-gated chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables phospholipid scramblase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    anoctamin-8
    Names
    transmembrane protein 16H

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164679.1 → NP_001158151.1  anoctamin-8

      See identical proteins and their annotated locations for NP_001158151.1

      Status: VALIDATED

      Source sequence(s)
      BC059855, BU708306, CD355145, CK624319, CX201380
      Consensus CDS
      CCDS52585.1
      UniProtKB/Swiss-Prot
      Q05CB5, Q69ZE4, Q6PB70
      UniProtKB/TrEMBL
      A0A1L1SR96
      Related
      ENSMUSP00000091157.5, ENSMUST00000093450.6
      Conserved Domains (1) summary
      pfam04547
      Location:237 → 475
      Anoctamin; Calcium-activated chloride channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71928660..71938735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243645.2 → XP_030099505.1  anoctamin-8 isoform X8

      UniProtKB/TrEMBL
      A0A1L1SR96
      Conserved Domains (2) summary
      pfam04547
      Location:198 → 456
      Anoctamin; Calcium-activated chloride channel
      pfam04625
      Location:883 → 1012
      DEC-1_N; DEC-1 protein, N-terminal region

    2. XM_017312871.2 → XP_017168360.1  anoctamin-8 isoform X1

      UniProtKB/TrEMBL
      A0A1L1SR96
      Conserved Domains (2) summary
      PRK12323
      Location:1031 → 1210
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam04547
      Location:237 → 606
      Anoctamin; Calcium-activated chloride channel

    3. XM_030243644.2 → XP_030099504.1  anoctamin-8 isoform X7

      UniProtKB/TrEMBL
      A0A1L1SR96
      Conserved Domains (2) summary
      PRK12323
      Location:881 → 1060
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam04547
      Location:198 → 456
      Anoctamin; Calcium-activated chloride channel

    4. XM_017312872.3 → XP_017168361.1  anoctamin-8 isoform X2

      UniProtKB/TrEMBL
      A0A1L1SR96
      Conserved Domains (2) summary
      PRK12323
      Location:992 → 1171
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam04547
      Location:198 → 567
      Anoctamin; Calcium-activated chloride channel

    5. XM_006509688.3 → XP_006509751.1  anoctamin-8 isoform X5

      UniProtKB/TrEMBL
      A0A1L1SR96
      Conserved Domains (2) summary
      PRK12323
      Location:920 → 1099
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam04547
      Location:237 → 495
      Anoctamin; Calcium-activated chloride channel

    6. XM_006509686.3 → XP_006509749.1  anoctamin-8 isoform X4

      UniProtKB/TrEMBL
      A0A1L1SR96
      Related
      ENSMUSP00000149365.2, ENSMUST00000213382.2
      Conserved Domains (2) summary
      PRK12323
      Location:964 → 1143
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam04547
      Location:237 → 539
      Anoctamin; Calcium-activated chloride channel

    7. XM_017312873.3 → XP_017168362.1  anoctamin-8 isoform X3

      UniProtKB/TrEMBL
      A0A1L1SR96
      Conserved Domains (2) summary
      PRK12323
      Location:978 → 1157
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam04547
      Location:184 → 553
      Anoctamin; Calcium-activated chloride channel

    8. XM_006509690.3 → XP_006509753.1  anoctamin-8 isoform X6

      UniProtKB/TrEMBL
      A0A1L1SR96
      Conserved Domains (2) summary
      PRK12323
      Location:895 → 1074
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam04547
      Location:237 → 470
      Anoctamin; Calcium-activated chloride channel
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PB70.3 GenPept UniProtKB/Swiss-Prot:Q6PB70

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