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    Scart2 scavenger receptor family member expressed on T cells 2 [ Mus musculus (house mouse) ]

    Gene ID: 244234, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Scart2provided by MGI
    Official Full Name
    scavenger receptor family member expressed on T cells 2provided by MGI
    Primary source
    MGI:MGI:2443685
    See related
    Ensembl:ENSMUSG00000054672 AllianceGenome:MGI:2443685
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5830411N06Rik
    Summary
    Acts upstream of or within gamma-delta T cell lineage commitment. Located in external side of plasma membrane. Is expressed in ileum; male reproductive gland or organ; and metanephros. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 4.6), mammary gland adult (RPKM 0.9) and 1 other tissue See more
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    Genomic context

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    See Scart2 in Genome Data Viewer
    Location:
    7 F4; 7 85.29 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139827192..139880647)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140247279..140300734)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20448 Neighboring gene olfactory receptor enhancer Fourni Neighboring gene olfactory receptor family 6 subfamily F member 2 Neighboring gene scavenger receptor family member expressed on T cells 1 Neighboring gene olfactory receptor family 6 subfamily B member 13 Neighboring gene predicted pseudogene 6314 Neighboring gene olfactory receptor family 13 subfamily A member 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SCART scavenger receptors identify a novel subset of adult gammadelta T cells. Kisielow J, et al. J Immunol, 2008 Aug 1. PMID 18641307
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. described two novel surface receptors, SCART1 and SCART2
      Title: SCART scavenger receptors identify a novel subset of adult gammadelta T cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within gamma-delta T cell lineage commitment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within interleukin-17 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    scavenger receptor family member expressed on T cells 2
    Names
    mFLJ00268 protein
    scavenger receptor protein family member

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128145.1 → NP_001121617.1  scavenger receptor family member expressed on T cells 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001121617.1

      Status: PROVISIONAL

      Source sequence(s)
      EF624463
      Consensus CDS
      CCDS52434.1
      UniProtKB/TrEMBL
      B3F5L5
      Related
      ENSMUSP00000091520.3, ENSMUST00000093984.3
      Conserved Domains (2) summary
      smart00202
      Location:551 → 651
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:162 → 233
      SRCR; Scavenger receptor cysteine-rich domain

    2. NM_001128146.1 → NP_001121618.1  scavenger receptor family member expressed on T cells 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001121618.1

      Status: PROVISIONAL

      Source sequence(s)
      EF624462
      Consensus CDS
      CCDS52433.1
      UniProtKB/TrEMBL
      B3F5L4
      Related
      ENSMUSP00000131905.2, ENSMUST00000164583.8
      Conserved Domains (2) summary
      smart00202
      Location:667 → 767
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:162 → 233
      SRCR; Scavenger receptor cysteine-rich domain

    3. NM_175533.3 → NP_780742.1  scavenger receptor family member expressed on T cells 2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_780742.1

      Status: PROVISIONAL

      Source sequence(s)
      AK040624
      UniProtKB/TrEMBL
      Q8C9T4
      Related
      ENSMUST00000059882.13
      Conserved Domains (2) summary
      smart00202
      Location:239 → 336
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:243 → 336
      SRCR; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      139827192..139880647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006536189.1 → XP_006536252.1  scavenger receptor family member expressed on T cells 2 isoform X2

      See identical proteins and their annotated locations for XP_006536252.1

      UniProtKB/TrEMBL
      B3F5L4
      Conserved Domains (2) summary
      smart00202
      Location:667 → 767
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:162 → 233
      SRCR; Scavenger receptor cysteine-rich domain

    2. XM_006536186.1 → XP_006536249.1  scavenger receptor family member expressed on T cells 2 isoform X1

      See identical proteins and their annotated locations for XP_006536249.1

      UniProtKB/TrEMBL
      B3F5L5
      Conserved Domains (2) summary
      smart00202
      Location:551 → 651
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:162 → 233
      SRCR; Scavenger receptor cysteine-rich domain

    RNA

    1. XR_389955.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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