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    Kash5 KASH domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 384619, updated on 27-Nov-2024

    Summary

    Official Symbol
    Kash5provided by MGI
    Official Full Name
    KASH domain containing 5provided by MGI
    Primary source
    MGI:MGI:2687329
    See related
    Ensembl:ENSMUSG00000038292 AllianceGenome:MGI:2687329
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1434; Ccdc155
    Summary
    Enables dynein complex binding activity and identical protein binding activity. Involved in cytoskeleton organization; spindle localization; and telomere localization. Acts upstream of or within several processes, including double-strand break repair via homologous recombination; homologous chromosome segregation; and spermatogenesis. Located in chromosome; meiotic spindle pole; and nuclear outer membrane. Part of meiotic nuclear membrane microtubule tethering complex. Is expressed in ovary; primary spermatocyte; spermatocyte; and testis. Human ortholog(s) of this gene implicated in primary ovarian insufficiency and spermatogenic failure 88. Orthologous to human KASH5 (KASH domain containing 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 31.9) and lung adult (RPKM 1.5) See more
    Orthologs
    NEW
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    Genomic context

    See Kash5 in Genome Data Viewer
    Location:
    7 B3; 7 29.17 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44833043..44854344, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45183619..45204919, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1733 Neighboring gene golgi-associated olfactory signaling regulator Neighboring gene STARR-seq mESC enhancer starr_18832 Neighboring gene parathyroid hormone 2 Neighboring gene predicted gene, 31097 Neighboring gene STARR-positive B cell enhancer ABC_E10438 Neighboring gene dickkopf-like 1 Neighboring gene TEA domain family member 2 Neighboring gene STARR-seq mESC enhancer starr_18834

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC60968

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dynein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromosome localization to nuclear envelope involved in homologous chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within chromosome localization to nuclear envelope involved in homologous chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in homologous chromosome pairing at meiosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within meiotic telomere clustering IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    acts_upstream_of_or_within oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spindle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spindle localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in telomere localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in telomere localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome, telomeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in lateral element IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lateral element IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of meiotic nuclear membrane microtubule tethering complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of meiotic nuclear membrane microtubule tethering complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in meiotic spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in meiotic spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nuclear outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein KASH5
    Names
    KASH domain-containing protein 5
    coiled-coil domain containing 155
    coiled-coil domain-containing protein 155
    NP_958762.2
    XP_006541031.1
    XP_011249173.1
    XP_017177818.1
    XP_017177820.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201374.2NP_958762.2  protein KASH5

      See identical proteins and their annotated locations for NP_958762.2

      Status: VALIDATED

      Source sequence(s)
      AC149868
      Consensus CDS
      CCDS21234.2
      UniProtKB/Swiss-Prot
      E9QNS3, E9QQ69, Q80VJ8
      Related
      ENSMUSP00000113616.3, ENSMUST00000121017.5
      Conserved Domains (3) summary
      pfam14658
      Location:108175
      EF-hand_9; EF-hand domain
      pfam14662
      Location:227418
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      cl12013
      Location:253415
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44833043..44854344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250871.3XP_011249173.1  protein KASH5 isoform X2

      Conserved Domains (2) summary
      pfam14658
      Location:38105
      EF-hand_9; EF-hand domain
      pfam14662
      Location:157347
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
    2. XM_017322329.2XP_017177818.1  protein KASH5 isoform X3

      Conserved Domains (2) summary
      pfam14658
      Location:77144
      EF-hand_9; EF-hand domain
      pfam14662
      Location:196371
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
    3. XM_006540968.4XP_006541031.1  protein KASH5 isoform X1

      Conserved Domains (2) summary
      pfam14658
      Location:77144
      EF-hand_9; EF-hand domain
      pfam14662
      Location:196386
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
    4. XM_017322331.3XP_017177820.1  protein KASH5 isoform X4

      Conserved Domains (2) summary
      pfam14658
      Location:77144
      EF-hand_9; EF-hand domain
      pfam14662
      Location:196305
      KASH_CCD; Coiled-coil region of CCDC155 or KASH

    RNA

    1. XR_003946500.2 RNA Sequence

    2. XR_001785582.3 RNA Sequence