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    Srrm3 serine/arginine repetitive matrix 3 [ Mus musculus (house mouse) ]

    Gene ID: 58212, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Srrm3provided by MGI
    Official Full Name
    serine/arginine repetitive matrix 3provided by MGI
    Primary source
    MGI:MGI:1920309
    See related
    Ensembl:ENSMUSG00000039860 AllianceGenome:MGI:1920309
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Srrm2l; SRm300-like; 2900083I11Rik
    Summary
    Predicted to enable mRNA binding activity. Predicted to be located in nucleus. Is expressed in brain; macula of utricle; and spinal cord. Orthologous to human SRRM3 (serine/arginine repetitive matrix 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 10.3), frontal lobe adult (RPKM 8.1) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Srrm3 in Genome Data Viewer
    Location:
    5 G2; 5 75.42 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135835693..135903627)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135806860..135874773)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene serine/threonine/tyrosine interacting-like 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:136254330-136254517 Neighboring gene predicted gene, 30205 Neighboring gene malate dehydrogenase 2, NAD (mitochondrial) Neighboring gene STARR-positive B cell enhancer ABC_E6387 Neighboring gene predicted gene, 22450 Neighboring gene heat shock protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse. Nakano Y, et al. Life Sci Alliance, 2020 Dec. PMID 33087486, Free PMC Article
    2. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article
    3. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse.
      Title: Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/arginine repetitive matrix protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403221.1 → NP_001390150.1  serine/arginine repetitive matrix protein 3

      Status: VALIDATED

      Source sequence(s)
      AC083948, AC084162
      UniProtKB/Swiss-Prot
      Q80WV7, Q9CUV5, Q9JJ91

    2. NM_021403.3 → NP_067378.2  serine/arginine repetitive matrix protein 3

      See identical proteins and their annotated locations for NP_067378.2

      Status: VALIDATED

      Source sequence(s)
      BC051947, BC058385
      Consensus CDS
      CCDS39319.2
      UniProtKB/Swiss-Prot
      Q80WV7, Q9CUV5, Q9JJ91
      Related
      ENSMUSP00000115695.2, ENSMUST00000144211.2
      Conserved Domains (2) summary
      pfam15230
      Location:527 → 583
      SRRM_C; Serine/arginine repetitive matrix protein C-terminus
      cd21376
      Location:34 → 101
      cwf21_SRRM3; cwf21 domain found in serine/arginine repetitive matrix protein 3 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      135835693..135903627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504472.3 → XP_006504535.1  serine/arginine repetitive matrix protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006504535.1

      UniProtKB/Swiss-Prot
      Q80WV7, Q9CUV5, Q9JJ91
      Conserved Domains (2) summary
      pfam15230
      Location:527 → 583
      SRRM_C; Serine/arginine repetitive matrix protein C-terminus
      cd21376
      Location:34 → 101
      cwf21_SRRM3; cwf21 domain found in serine/arginine repetitive matrix protein 3 and similar proteins

    2. XM_036165389.1 → XP_036021282.1  serine/arginine repetitive matrix protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q80WV7, Q9CUV5, Q9JJ91
      Conserved Domains (2) summary
      pfam15230
      Location:527 → 583
      SRRM_C; Serine/arginine repetitive matrix protein C-terminus
      cd21376
      Location:34 → 101
      cwf21_SRRM3; cwf21 domain found in serine/arginine repetitive matrix protein 3 and similar proteins

    3. XM_036165391.1 → XP_036021284.1  serine/arginine repetitive matrix protein 3 isoform X3

      Conserved Domains (1) summary
      pfam15230
      Location:233 → 289
      SRRM_C; Serine/arginine repetitive matrix protein C-terminus

    4. XM_036165388.1 → XP_036021281.1  serine/arginine repetitive matrix protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q80WV7, Q9CUV5, Q9JJ91
      Conserved Domains (2) summary
      pfam15230
      Location:527 → 583
      SRRM_C; Serine/arginine repetitive matrix protein C-terminus
      cd21376
      Location:34 → 101
      cwf21_SRRM3; cwf21 domain found in serine/arginine repetitive matrix protein 3 and similar proteins

    5. XM_036165390.1 → XP_036021283.1  serine/arginine repetitive matrix protein 3 isoform X3

      Conserved Domains (1) summary
      pfam15230
      Location:233 → 289
      SRRM_C; Serine/arginine repetitive matrix protein C-terminus

    6. XM_036165392.1 → XP_036021285.1  serine/arginine repetitive matrix protein 3 isoform X4

      UniProtKB/TrEMBL
      H7BWX3
      Related
      ENSMUSP00000013615.8, ENSMUST00000013615.14
      Conserved Domains (1) summary
      cd21376
      Location:34 → 101
      cwf21_SRRM3; cwf21 domain found in serine/arginine repetitive matrix protein 3 and similar proteins

    7. XM_011240902.3 → XP_011239204.1  serine/arginine repetitive matrix protein 3 isoform X4

      UniProtKB/TrEMBL
      H7BWX3
      Conserved Domains (1) summary
      cd21376
      Location:34 → 101
      cwf21_SRRM3; cwf21 domain found in serine/arginine repetitive matrix protein 3 and similar proteins

    8. XM_006504475.5 → XP_006504538.1  serine/arginine repetitive matrix protein 3 isoform X5

      Conserved Domains (2) summary
      PRK13411
      Location:49 → 136
      PRK13411; molecular chaperone DnaK; Provisional
      pfam08312
      Location:56 → 98
      cwf21; cwf21 domain

    9. XM_006504473.5 → XP_006504536.1  serine/arginine repetitive matrix protein 3 isoform X2

      Conserved Domains (1) summary
      pfam15230
      Location:408 → 464
      SRRM_C; Serine/arginine repetitive matrix protein C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80WV7.1 GenPept UniProtKB/Swiss-Prot:Q80WV7

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