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    Ccdc60 coiled-coil domain containing 60 [ Mus musculus (house mouse) ]

    Gene ID: 269693, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccdc60provided by MGI
    Official Full Name
    coiled-coil domain containing 60provided by MGI
    Primary source
    MGI:MGI:2141043
    See related
    Ensembl:ENSMUSG00000043913 AllianceGenome:MGI:2141043
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C130098D09
    Summary
    Is expressed in central nervous system; craniocervical region bone; dorsal root ganglion; and rib. Orthologous to human CCDC60 (coiled-coil domain containing 60). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 123.1) See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc60 in Genome Data Viewer
    Location:
    5 F; 5 56.12 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (116263640..116427059, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (116125581..116289000, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8073 Neighboring gene predicted gene 13842 Neighboring gene transmembrane protein 233 Neighboring gene RIKEN cDNA C330018A13 gene Neighboring gene STARR-seq mESC enhancer starr_14145 Neighboring gene predicted gene, 36552 Neighboring gene predicted gene, 36502 Neighboring gene predicted gene, 52827 Neighboring gene RIKEN cDNA B230112J18 gene Neighboring gene RIKEN cDNA 4933424N20 gene Neighboring gene STARR-seq mESC enhancer starr_14150

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 60

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360004.1 → NP_001346933.1  coiled-coil domain-containing protein 60 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 5' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AC115795, AC119977, AC158756
      UniProtKB/TrEMBL
      B7ZWG5
      Conserved Domains (1) summary
      pfam15769
      Location:59 → 533
      DUF4698; Domain of unknown function (DUF4698)

    2. NM_001360005.1 → NP_001346934.1  coiled-coil domain-containing protein 60 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC158756, BC075662
      Consensus CDS
      CCDS89981.1
      UniProtKB/TrEMBL
      A0A0R4J120
      Related
      ENSMUSP00000083671.4, ENSMUST00000086483.4
      Conserved Domains (1) summary
      pfam15769
      Location:60 → 187
      DUF4698; Domain of unknown function (DUF4698)

    3. NM_177759.3 → NP_808427.1  coiled-coil domain-containing protein 60 isoform 1

      See identical proteins and their annotated locations for NP_808427.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK082047
      Consensus CDS
      CCDS19599.1
      UniProtKB/Swiss-Prot
      B2RX39, Q6DIA4, Q6PAQ3, Q8C4J0
      UniProtKB/TrEMBL
      B7ZWG5
      Related
      ENSMUSP00000049912.7, ENSMUST00000050178.13
      Conserved Domains (1) summary
      pfam15769
      Location:60 → 534
      DUF4698; Domain of unknown function (DUF4698)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      116263640..116427059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320898.2 → XP_017176387.1  coiled-coil domain-containing protein 60 isoform X2

      UniProtKB/TrEMBL
      B7ZWG5
      Conserved Domains (1) summary
      pfam15769
      Location:59 → 550
      DUF4698; Domain of unknown function (DUF4698)

    2. XM_030254535.1 → XP_030110395.1  coiled-coil domain-containing protein 60 isoform X4

      UniProtKB/TrEMBL
      B7ZWG5
      Conserved Domains (1) summary
      pfam15769
      Location:60 → 533
      DUF4698; Domain of unknown function (DUF4698)

    3. XM_017320899.2 → XP_017176388.1  coiled-coil domain-containing protein 60 isoform X3

      UniProtKB/TrEMBL
      B7ZWG5
      Conserved Domains (1) summary
      pfam15769
      Location:60 → 550
      DUF4698; Domain of unknown function (DUF4698)

    4. XM_006530340.4 → XP_006530403.1  coiled-coil domain-containing protein 60 isoform X1

      UniProtKB/TrEMBL
      B7ZWG5
      Conserved Domains (1) summary
      pfam15769
      Location:60 → 551
      DUF4698; Domain of unknown function (DUF4698)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C4J0.1 GenPept UniProtKB/Swiss-Prot:Q8C4J0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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