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    Fabp12 fatty acid binding protein 12 [ Mus musculus (house mouse) ]

    Gene ID: 75497, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fabp12provided by MGI
    Official Full Name
    fatty acid binding protein 12provided by MGI
    Primary source
    MGI:MGI:1922747
    See related
    Ensembl:ENSMUSG00000027530 AllianceGenome:MGI:1922747
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700008G05Rik
    Summary
    Predicted to enable fatty acid binding activity. Predicted to be involved in fatty acid transport. Predicted to be active in cytosol and nucleus. Is expressed in retina inner nuclear layer and retina outer nuclear layer. Orthologous to human FABP12 (fatty acid binding protein 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 2.8), liver E18 (RPKM 0.8) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fabp12 in Genome Data Viewer
    Location:
    3 A1; 3 2.57 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (10309269..10366575, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (10244209..10301515, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene fatty acid binding protein 9, testis Neighboring gene fatty acid binding protein 4, adipocyte Neighboring gene STARR-seq mESC enhancer starr_06936 Neighboring gene STARR-positive B cell enhancer ABC_E10175 Neighboring gene STARR-seq mESC enhancer starr_06939 Neighboring gene predicted gene, 37316 Neighboring gene inositol (myo)-1(or 4)-monophosphatase 1 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cell-type-specific regulation of genes involved in testicular lipid metabolism: fatty acid-binding proteins, diacylglycerol acyltransferases, and perilipin 2. Oresti GM, et al. Reproduction, 2013. PMID 23962454
    2. A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis. Liu RZ, et al. Genomics, 2008 Dec. PMID 18786628
    3. Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality. Sah RK, et al. Int J Mol Sci, 2020 Nov 3. PMID 33153107, Free PMC Article
    4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FABP12 arose as the result of tandem gene duplication, a mechanism that may have been instrumental to the expansion of the FABP family.
      Title: A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fatty acid-binding protein 12
    Names
    intracellular fatty acid-binding protein FABP12
    probable fatty acid-binding protein ENSP00000353650 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357159.1 → NP_001344088.1  fatty acid-binding protein 12

      Status: VALIDATED

      Source sequence(s)
      AC123726, BC030910
      Consensus CDS
      CCDS17239.1
      UniProtKB/Swiss-Prot
      B7SUM9, Q9DAK4
      Related
      ENSMUSP00000112958.2, ENSMUST00000119761.2
      Conserved Domains (1) summary
      cd19617
      Location:4 → 131
      FABP12; fatty acid-binding protein 12

    2. NM_001357160.1 → NP_001344089.1  fatty acid-binding protein 12

      Status: VALIDATED

      Source sequence(s)
      AC123726, AK005765, BC030910
      Consensus CDS
      CCDS17239.1
      UniProtKB/Swiss-Prot
      B7SUM9, Q9DAK4
      Related
      ENSMUSP00000112464.2, ENSMUST00000117917.8
      Conserved Domains (1) summary
      cd19617
      Location:4 → 131
      FABP12; fatty acid-binding protein 12

    3. NM_001357161.1 → NP_001344090.1  fatty acid-binding protein 12

      Status: VALIDATED

      Source sequence(s)
      AC123726, AK005765, BC030910
      Consensus CDS
      CCDS17239.1
      UniProtKB/Swiss-Prot
      B7SUM9, Q9DAK4
      Related
      ENSMUSP00000131101.2, ENSMUST00000172126.8
      Conserved Domains (1) summary
      cd19617
      Location:4 → 131
      FABP12; fatty acid-binding protein 12

    4. NM_029310.1 → NP_083586.1  fatty acid-binding protein 12

      See identical proteins and their annotated locations for NP_083586.1

      Status: VALIDATED

      Source sequence(s)
      BC030910
      Consensus CDS
      CCDS17239.1
      UniProtKB/Swiss-Prot
      B7SUM9, Q9DAK4
      Related
      ENSMUSP00000029043.7, ENSMUST00000029043.13
      Conserved Domains (1) summary
      cd19617
      Location:4 → 131
      FABP12; fatty acid-binding protein 12

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      10309269..10366575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319783.2 → XP_017175272.1  fatty acid-binding protein 12 isoform X1

      UniProtKB/Swiss-Prot
      B7SUM9, Q9DAK4
      Conserved Domains (1) summary
      cd19617
      Location:4 → 131
      FABP12; fatty acid-binding protein 12

    2. XM_006530099.5 → XP_006530162.1  fatty acid-binding protein 12 isoform X1

      See identical proteins and their annotated locations for XP_006530162.1

      UniProtKB/Swiss-Prot
      B7SUM9, Q9DAK4
      Conserved Domains (1) summary
      cd19617
      Location:4 → 131
      FABP12; fatty acid-binding protein 12

    3. XM_036163370.1 → XP_036019263.1  fatty acid-binding protein 12 isoform X1

      UniProtKB/Swiss-Prot
      B7SUM9, Q9DAK4
      Conserved Domains (1) summary
      cd19617
      Location:4 → 131
      FABP12; fatty acid-binding protein 12

    4. XM_036163371.1 → XP_036019264.1  fatty acid-binding protein 12 isoform X1

      UniProtKB/Swiss-Prot
      B7SUM9, Q9DAK4
      Conserved Domains (1) summary
      cd19617
      Location:4 → 131
      FABP12; fatty acid-binding protein 12

    5. XM_006530096.4 → XP_006530159.1  fatty acid-binding protein 12 isoform X1

      See identical proteins and their annotated locations for XP_006530159.1

      UniProtKB/Swiss-Prot
      B7SUM9, Q9DAK4
      Conserved Domains (1) summary
      cd19617
      Location:4 → 131
      FABP12; fatty acid-binding protein 12

    6. XM_006530097.3 → XP_006530160.1  fatty acid-binding protein 12 isoform X1

      See identical proteins and their annotated locations for XP_006530160.1

      UniProtKB/Swiss-Prot
      B7SUM9, Q9DAK4
      Conserved Domains (1) summary
      cd19617
      Location:4 → 131
      FABP12; fatty acid-binding protein 12

    RNA

    1. XR_004941410.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAK4.1 GenPept UniProtKB/Swiss-Prot:Q9DAK4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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