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    Sema6d sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D [ Mus musculus (house mouse) ]

    Gene ID: 214968, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sema6dprovided by MGI
    Official Full Name
    sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Dprovided by MGI
    Primary source
    MGI:MGI:2387661
    See related
    Ensembl:ENSMUSG00000027200 AllianceGenome:MGI:2387661
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1479; D330011G23; 1110067B02Rik
    Summary
    Enables receptor ligand activity and semaphorin receptor binding activity. Involved in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell and semaphorin-plexin signaling pathway. Acts upstream of or within negative regulation of smooth muscle cell migration; positive regulation of smooth muscle cell migration; and ventricular system development. Located in collagen-containing extracellular matrix. Is expressed in several structures, including central nervous system; gut mesenchyme; retina; spinal ganglion or nerve; and vascular element. Orthologous to human SEMA6D (semaphorin 6D). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 11.2), lung adult (RPKM 8.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sema6d in Genome Data Viewer
    Location:
    2 F1; 2 60.69 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (123931089..124509711)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (124089943..124667789)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05565 Neighboring gene predicted gene, 54147 Neighboring gene STARR-seq mESC enhancer starr_05566 Neighboring gene STARR-positive B cell enhancer mm9_chr2:123404999-123405300 Neighboring gene STARR-seq mESC enhancer starr_05568 Neighboring gene predicted gene, 39919 Neighboring gene STARR-seq mESC enhancer starr_05570 Neighboring gene RIKEN cDNA 4930517E11 gene Neighboring gene STARR-seq mESC enhancer starr_05571 Neighboring gene RIKEN cDNA 4930583P06 gene Neighboring gene STARR-seq mESC enhancer starr_05573 Neighboring gene STARR-seq mESC enhancer starr_05574 Neighboring gene STARR-seq mESC enhancer starr_05575 Neighboring gene STARR-seq mESC enhancer starr_05576 Neighboring gene STARR-positive B cell enhancer ABC_E5974 Neighboring gene predicted gene, 54148 Neighboring gene predicted gene, 34484 Neighboring gene predicted gene, 39920

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancer. Hirai T, et al. JCI Insight, 2024 Feb 8. PMID 38329122, Free PMC Article
    2. Semaphorin 6D regulate corralling, hematoma compaction and white matter injury in mice after intracerebral hemorrhage. Sun T, et al. J Stroke Cerebrovasc Dis, 2022 Nov. PMID 36174325
    3. Semaphorin 6D regulates the late phase of CD4+ T cell primary immune responses. O'Connor BP, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18728195, Free PMC Article
    4. Characterization of a novel member of murine semaphorin family. Taniguchi M, et al. Biochem Biophys Res Commun, 2004 Jan 30. PMID 14715272
    5. Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs. Nakanishi Y, et al. Neuron, 2024 Sep 4. PMID 39002542

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs.
      Title: Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs.
    2. Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancer.
      Title: Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancer.
    3. Semaphorin-6D and Plexin-A1 Act in a Non-Cell-Autonomous Manner to Position and Target Retinal Ganglion Cell Axons.
      Title: Semaphorin-6D and Plexin-A1 Act in a Non-Cell-Autonomous Manner to Position and Target Retinal Ganglion Cell Axons.
    4. Semaphorin 6D regulate corralling, hematoma compaction and white matter injury in mice after intracerebral hemorrhage.
      Title: Semaphorin 6D regulate corralling, hematoma compaction and white matter injury in mice after intracerebral hemorrhage.
    5. Embryonic heart deletion of Sema6D significantly impaired the cardiac contraction of male adult hearts, while having a minor effect on female mutant hearts, suggesting that the effect of Sema6D-deletion in adult hearts is sex dependent.
      Title: SEMA6D regulates perinatal cardiomyocyte proliferation and maturation in mice.
    6. these findings highlight crucial roles for Sema6D reverse signaling in macrophage polarization, coupling immunity, and metabolism via PPARgamma.
      Title: Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization.
    7. Shear stress-regulated miR-27b promotes the interaction of endothelial cells with pericytes, partly by repressing SEMA6A and SEMA6D.
      Title: Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D.
    8. BMP-SEMA6D-Rho axis plays a key role in the initial stages of AV cushion mesenchyme formation.
      Title: Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice.
    9. Class 6 transmembrane semaphorins are unlikely to serve as major PlexA receptor ligands for the assembly of murine retinal circuit laminar organization.
      Title: Sema6B, Sema6C, and Sema6D expression and function during mammalian retinal development.
    10. These findings suggest a mechanism by which a complex of Sema6D, Nr-CAM, and Plexin-A1 at the chiasm midline alters the sign of Sema6D and signals Nr-CAM/Plexin-A1 receptors on retinal ganglion cells to implement the contralateral retinal cell projection.
      Title: Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chemorepellent activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables semaphorin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables semaphorin receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of smooth muscle cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neural crest cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of smooth muscle cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in semaphorin-plexin signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in semaphorin-plexin signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of smooth muscle cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within ventricular system development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within ventricular system development ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    semaphorin-6D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290997.2 → NP_001277926.1  semaphorin-6D isoform Sema6D-2 precursor

      See identical proteins and their annotated locations for NP_001277926.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (Sema6D-2) is shorter than isoform Sema6D-1. Both variants 2 and 3 encode isoform Sema6D-2.
      Source sequence(s)
      AL833808, AL928992, AL929570, AL935323
      Consensus CDS
      CCDS16671.1
      UniProtKB/Swiss-Prot
      Q76KF0
      Related
      ENSMUSP00000099531.2, ENSMUST00000103241.8
      Conserved Domains (3) summary
      PHA03247
      Location:834 → 981
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    2. NM_001291000.2 → NP_001277929.1  semaphorin-6D isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) uses an alternate in-frame splice site and contains two additional in-frame exons in the central coding region, compared to variant 1. The encoded isoform (3) is longer than isoform Sema6D-1.
      Source sequence(s)
      AL929517, AL935323
      Consensus CDS
      CCDS71132.1
      UniProtKB/TrEMBL
      A2AW73
      Related
      ENSMUSP00000099530.3, ENSMUST00000103240.9
      Conserved Domains (3) summary
      PHA03247
      Location:905 → 1052
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    3. NM_001407285.1 → NP_001394214.1  semaphorin-6D isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AL929517, AL935323

    4. NM_172537.5 → NP_766125.2  semaphorin-6D isoform Sema6D-1 precursor

      See identical proteins and their annotated locations for NP_766125.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform Sema6D-1.
      Source sequence(s)
      AL929517, AL935323
      Consensus CDS
      CCDS16670.1
      UniProtKB/Swiss-Prot
      Q76KF0
      Related
      ENSMUSP00000061123.9, ENSMUST00000051419.15
      Conserved Domains (3) summary
      PHA03247
      Location:847 → 994
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 582
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    5. NM_199238.4 → NP_954708.1  semaphorin-6D isoform Sema6D-2 precursor

      See identical proteins and their annotated locations for NP_954708.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (Sema6D-2) that is shorter than isoform Sema6D-1. Both variants 2 and 3 encode isoform Sema6D-2.
      Source sequence(s)
      AL929517, AL935323
      Consensus CDS
      CCDS16671.1
      UniProtKB/Swiss-Prot
      Q76KF0
      Related
      ENSMUSP00000075674.6, ENSMUST00000076335.12
      Conserved Domains (3) summary
      PHA03247
      Location:834 → 981
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    6. NM_199239.4 → NP_954709.1  semaphorin-6D isoform Sema6D-5 precursor

      See identical proteins and their annotated locations for NP_954709.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an additional in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (Sema6D-5) that is longer than isoform Sema6D-1. The 5' UTR is incomplete because the evidence for this variant is for the CDS only, and multiple possible 5' UTR exon combinations exist.
      Source sequence(s)
      AL935323
      Consensus CDS
      CCDS38225.1
      UniProtKB/Swiss-Prot
      Q76KF0
      Related
      ENSMUSP00000077691.6, ENSMUST00000078621.12
      Conserved Domains (3) summary
      PHA03247
      Location:866 → 1013
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 543
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    7. NM_199240.4 → NP_954710.1  semaphorin-6D isoform Sema6D-6 precursor

      See identical proteins and their annotated locations for NP_954710.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site and contains an additional in-frame exon in the central coding region, compared to variant 1. The encoded isoform (Sema6D-6) is longer than isoform Sema6D-1. The 5' UTR is incomplete because the evidence for this variant is for the CDS only, and multiple possible 5' UTR exon combinations exist.
      Source sequence(s)
      AL935323
      Consensus CDS
      CCDS16672.1
      UniProtKB/Swiss-Prot
      Q76KF0
      Related
      ENSMUSP00000099528.2, ENSMUST00000103238.2
      Conserved Domains (3) summary
      PHA03247
      Location:890 → 1037
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    8. NM_199241.4 → NP_954711.1  semaphorin-6D isoform Sema6D-4 precursor

      See identical proteins and their annotated locations for NP_954711.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site and contains two additional in-frame exons in the central coding region, compared to variant 1. The encoded isoform (Sema6D-4) is longer than isoform Sema6D-1. The 5' UTR is incomplete because the evidence for this variant is for the CDS only, and multiple possible 5' UTR exon combinations exist.
      Source sequence(s)
      AL935323
      Consensus CDS
      CCDS16673.1
      UniProtKB/Swiss-Prot
      A2AW72, Q76KF0, Q76KF1, Q76KF2, Q76KF3, Q76KF4, Q80TD0
      Conserved Domains (3) summary
      PHA03247
      Location:909 → 1056
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      123931089..124509711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249334.2 → XP_030105194.1  semaphorin-6D isoform X1

      Conserved Domains (3) summary
      PHA03247
      Location:922 → 1069
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 543
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    2. XM_036160315.1 → XP_036016208.1  semaphorin-6D isoform X7

      Conserved Domains (3) summary
      PHA03247
      Location:890 → 1037
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    3. XM_036160329.1 → XP_036016222.1  semaphorin-6D isoform X12

      Conserved Domains (3) summary
      PHA03247
      Location:834 → 981
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    4. XM_006499112.5 → XP_006499175.1  semaphorin-6D isoform X1

      See identical proteins and their annotated locations for XP_006499175.1

      Conserved Domains (3) summary
      PHA03247
      Location:922 → 1069
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 543
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    5. XM_036160290.1 → XP_036016183.1  semaphorin-6D isoform X2

      Conserved Domains (3) summary
      PHA03247
      Location:918 → 1065
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 543
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    6. XM_036160325.1 → XP_036016218.1  semaphorin-6D isoform X9

      Conserved Domains (3) summary
      PHA03247
      Location:866 → 1013
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 543
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    7. XM_036160303.1 → XP_036016196.1  semaphorin-6D isoform X5

      Conserved Domains (3) summary
      PHA03247
      Location:903 → 1050
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 543
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    8. XM_036160310.1 → XP_036016203.1  semaphorin-6D isoform X6

      Conserved Domains (3) summary
      PHA03247
      Location:899 → 1046
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 543
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    9. XM_030249369.2 → XP_030105229.1  semaphorin-6D isoform X11

      Conserved Domains (3) summary
      PHA03247
      Location:847 → 994
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 582
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    10. XM_036160291.1 → XP_036016184.1  semaphorin-6D isoform X3

      UniProtKB/Swiss-Prot
      A2AW72, Q76KF0, Q76KF1, Q76KF2, Q76KF3, Q76KF4, Q80TD0
      Conserved Domains (3) summary
      PHA03247
      Location:909 → 1056
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    11. XM_036160298.1 → XP_036016191.1  semaphorin-6D isoform X4

      UniProtKB/TrEMBL
      A2AW73
      Conserved Domains (3) summary
      PHA03247
      Location:905 → 1052
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    12. XM_036160326.1 → XP_036016219.1  semaphorin-6D isoform X10

      Conserved Domains (3) summary
      PHA03247
      Location:853 → 1000
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    13. XM_011239427.4 → XP_011237729.1  semaphorin-6D isoform X7

      See identical proteins and their annotated locations for XP_011237729.1

      UniProtKB/Swiss-Prot
      Q76KF0
      Conserved Domains (3) summary
      PHA03247
      Location:890 → 1037
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    14. XM_030249365.2 → XP_030105225.1  semaphorin-6D isoform X8

      Conserved Domains (3) summary
      PHA03247
      Location:886 → 1033
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    15. XM_030249372.2 → XP_030105232.1  semaphorin-6D isoform X12

      Conserved Domains (3) summary
      PHA03247
      Location:834 → 981
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    16. XM_036160336.1 → XP_036016229.1  semaphorin-6D isoform X18

      UniProtKB/TrEMBL
      Q8BKG8
      Conserved Domains (2) summary
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    17. XM_036160335.1 → XP_036016228.1  semaphorin-6D isoform X17

      UniProtKB/TrEMBL
      Q8BKG8
      Conserved Domains (2) summary
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    18. XM_036160331.1 → XP_036016224.1  semaphorin-6D isoform X13

      UniProtKB/TrEMBL
      Q8BKG8
      Conserved Domains (2) summary
      pfam01437
      Location:514 → 543
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    19. XM_036160332.1 → XP_036016225.1  semaphorin-6D isoform X14

      UniProtKB/TrEMBL
      Q8BKG8
      Conserved Domains (2) summary
      pfam01437
      Location:514 → 543
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    20. XM_036160333.1 → XP_036016226.1  semaphorin-6D isoform X15

      UniProtKB/TrEMBL
      Q8BKG8
      Conserved Domains (2) summary
      pfam01437
      Location:514 → 543
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    21. XM_036160334.1 → XP_036016227.1  semaphorin-6D isoform X16

      UniProtKB/TrEMBL
      Q8BKG8
      Conserved Domains (2) summary
      pfam01437
      Location:514 → 543
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    22. XM_036160337.1 → XP_036016230.1  semaphorin-6D isoform X19

      UniProtKB/TrEMBL
      Q8BKG8
      Conserved Domains (2) summary
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    23. XM_036160283.1 → XP_036016176.1  semaphorin-6D isoform X1

      Conserved Domains (3) summary
      PHA03247
      Location:922 → 1069
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 543
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    24. XM_036160288.1 → XP_036016181.1  semaphorin-6D isoform X1

      Conserved Domains (3) summary
      PHA03247
      Location:922 → 1069
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 543
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    25. XM_036160285.1 → XP_036016178.1  semaphorin-6D isoform X1

      Conserved Domains (3) summary
      PHA03247
      Location:922 → 1069
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 543
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    26. XM_006499113.5 → XP_006499176.1  semaphorin-6D isoform X1

      See identical proteins and their annotated locations for XP_006499176.1

      Conserved Domains (3) summary
      PHA03247
      Location:922 → 1069
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 543
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    27. XM_030249357.2 → XP_030105217.1  semaphorin-6D isoform X5

      Conserved Domains (3) summary
      PHA03247
      Location:903 → 1050
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 543
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    28. XM_030249371.2 → XP_030105231.1  semaphorin-6D isoform X11

      Conserved Domains (3) summary
      PHA03247
      Location:847 → 994
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 582
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    29. XM_030249343.2 → XP_030105203.1  semaphorin-6D isoform X3

      UniProtKB/Swiss-Prot
      A2AW72, Q76KF0, Q76KF1, Q76KF2, Q76KF3, Q76KF4, Q80TD0
      Conserved Domains (3) summary
      PHA03247
      Location:909 → 1056
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    30. XM_030249347.2 → XP_030105207.1  semaphorin-6D isoform X4

      UniProtKB/TrEMBL
      A2AW73
      Conserved Domains (3) summary
      PHA03247
      Location:905 → 1052
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    31. XM_030249368.2 → XP_030105228.1  semaphorin-6D isoform X10

      Conserved Domains (3) summary
      PHA03247
      Location:853 → 1000
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    32. XM_030249361.2 → XP_030105221.1  semaphorin-6D isoform X7

      Conserved Domains (3) summary
      PHA03247
      Location:890 → 1037
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    33. XM_030249366.2 → XP_030105226.1  semaphorin-6D isoform X8

      Conserved Domains (3) summary
      PHA03247
      Location:886 → 1033
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    34. XM_030249373.2 → XP_030105233.1  semaphorin-6D isoform X12

      Conserved Domains (3) summary
      PHA03247
      Location:834 → 981
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    35. XM_006499111.4 → XP_006499174.1  semaphorin-6D isoform X1

      See identical proteins and their annotated locations for XP_006499174.1

      Conserved Domains (3) summary
      PHA03247
      Location:922 → 1069
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 543
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    36. XM_017317001.2 → XP_017172490.1  semaphorin-6D isoform X3

      UniProtKB/Swiss-Prot
      A2AW72, Q76KF0, Q76KF1, Q76KF2, Q76KF3, Q76KF4, Q80TD0
      Related
      ENSMUSP00000099529.4, ENSMUST00000103239.10
      Conserved Domains (3) summary
      PHA03247
      Location:909 → 1056
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    37. XM_017317012.2 → XP_017172501.1  semaphorin-6D isoform X7

      UniProtKB/Swiss-Prot
      Q76KF0
      Related
      ENSMUSP00000077014.6, ENSMUST00000077847.12
      Conserved Domains (3) summary
      PHA03247
      Location:890 → 1037
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    38. XM_006499114.5 → XP_006499177.1  semaphorin-6D isoform X1

      See identical proteins and their annotated locations for XP_006499177.1

      Conserved Domains (3) summary
      PHA03247
      Location:922 → 1069
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 543
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    39. XM_030249345.2 → XP_030105205.1  semaphorin-6D isoform X3

      UniProtKB/Swiss-Prot
      A2AW72, Q76KF0, Q76KF1, Q76KF2, Q76KF3, Q76KF4, Q80TD0
      Conserved Domains (3) summary
      PHA03247
      Location:909 → 1056
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    40. XM_030249351.2 → XP_030105211.1  semaphorin-6D isoform X4

      UniProtKB/TrEMBL
      A2AW73
      Conserved Domains (3) summary
      PHA03247
      Location:905 → 1052
      PHA03247; large tegument protein UL36; Provisional
      pfam01437
      Location:514 → 569
      PSI; Plexin repeat
      cl15693
      Location:49 → 513
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q76KF0.1 GenPept UniProtKB/Swiss-Prot:Q76KF0

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