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    Ak8 adenylate kinase 8 [ Mus musculus (house mouse) ]

    Gene ID: 68870, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ak8provided by MGI
    Official Full Name
    adenylate kinase 8provided by MGI
    Primary source
    MGI:MGI:1916120
    See related
    Ensembl:ENSMUSG00000026807 AllianceGenome:MGI:1916120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AK 8; 1190002A17Rik
    Summary
    Predicted to enable (d)CMP kinase activity; adenylate kinase activity; and nucleoside diphosphate kinase activity. Acts upstream of or within ventricular system development. Located in axoneme and sperm flagellum. Used to study hydrocephalus. Orthologous to human AK8 (adenylate kinase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 80.2) See more
    Orthologs
    human all
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    Genomic context

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    See Ak8 in Genome Data Viewer
    Location:
    2 A3; 2 19.38 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (28588287..28703177)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (28698275..28813165)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2606 Neighboring gene STARR-positive B cell enhancer ABC_E3365 Neighboring gene STARR-positive B cell enhancer ABC_E2033 Neighboring gene predicted gene, 52548 Neighboring gene growth factor independent 1B Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:28496521-28496713 Neighboring gene TSC complex subunit 1 Neighboring gene sperm acrosome associated 9 Neighboring gene microRNA 3088 Neighboring gene STARR-seq mESC enhancer starr_04033 Neighboring gene high mobility group box 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10088 Neighboring gene general transcription factor IIIC, polypeptide 4 Neighboring gene DEAD/H box helicase 31 Neighboring gene BarH like homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Adenine nucleotide metabolism and a role for AMP in modulating flagellar waveforms in mouse sperm. Vadnais ML, et al. Biol Reprod, 2014 Jun. PMID 24740601, Free PMC Article
    2. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Kisseleva T, et al. Proc Natl Acad Sci U S A, 2012 Jun 12. PMID 22566629, Free PMC Article
    3. CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module. Dougherty GW, et al. Nat Commun, 2020 Nov 2. PMID 33139725, Free PMC Article
    4. Congenital hydrocephalus in genetically engineered mice. Vogel P, et al. Vet Pathol, 2012 Jan. PMID 21746835
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118311, MGC130365

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables (d)CMP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables (d)CMP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables AMP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenylate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleoside diphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleoside diphosphate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleoside monophosphate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ventricular system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenylate kinase 8
    Names
    ATP-AMP transphosphorylase 8
    Adenylate kinase isoenzyme 4, mitochondrial (ATP-AMP transphosphorylase)
    putative adenylate kinase-like protein C9orf98 homolog
    NP_001029046.2
    XP_006498350.1
    XP_006498351.1
    XP_006498352.1
    XP_006498354.1
    XP_017174733.1
    XP_017174734.1
    XP_030107901.1
    XP_030107902.1
    XP_036018423.1
    XP_036018424.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033874.2 → NP_001029046.2  adenylate kinase 8

      See identical proteins and their annotated locations for NP_001029046.2

      Status: VALIDATED

      Source sequence(s)
      AB046266, BC109352, BY100469
      Consensus CDS
      CCDS15846.1
      UniProtKB/Swiss-Prot
      Q32M07, Q497L2
      Related
      ENSMUSP00000073789.7, ENSMUST00000074156.7
      Conserved Domains (2) summary
      cd01428
      Location:270 → 462
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01351
      Location:270 → 468
      adk; adenylate kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      28588287..28703177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498287.4 → XP_006498350.1  adenylate kinase 8 isoform X1

      See identical proteins and their annotated locations for XP_006498350.1

      Conserved Domains (1) summary
      cd01428
      Location:299 → 491
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    2. XM_006498288.5 → XP_006498351.1  adenylate kinase 8 isoform X1

      See identical proteins and their annotated locations for XP_006498351.1

      Conserved Domains (1) summary
      cd01428
      Location:299 → 491
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    3. XM_036162530.1 → XP_036018423.1  adenylate kinase 8 isoform X6

      Conserved Domains (1) summary
      cd01428
      Location:241 → 433
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    4. XM_036162531.1 → XP_036018424.1  adenylate kinase 8 isoform X7

      Conserved Domains (1) summary
      cd01428
      Location:240 → 432
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    5. XM_006498291.4 → XP_006498354.1  adenylate kinase 8 isoform X4

      Conserved Domains (1) summary
      cd01428
      Location:270 → 462
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    6. XM_030252041.2 → XP_030107901.1  adenylate kinase 8 isoform X1

      Conserved Domains (1) summary
      cd01428
      Location:299 → 491
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    7. XM_006498289.2 → XP_006498352.1  adenylate kinase 8 isoform X2

      Conserved Domains (1) summary
      cd01428
      Location:298 → 490
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    8. XM_017319245.2 → XP_017174734.1  adenylate kinase 8 isoform X8

      Conserved Domains (2) summary
      cd01428
      Location:88 → 278
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      cl17190
      Location:299 → 352
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    9. XM_030252042.1 → XP_030107902.1  adenylate kinase 8 isoform X5

      Conserved Domains (1) summary
      cd01428
      Location:269 → 461
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    10. XM_017319244.3 → XP_017174733.1  adenylate kinase 8 isoform X3

      Conserved Domains (1) summary
      cd01428
      Location:272 → 464
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32M07.1 GenPept UniProtKB/Swiss-Prot:Q32M07

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