Ccar1 cell division cycle and apoptosis regulator 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ccar1provided by RGD
Full Name: cell division cycle and apoptosis regulator 1provided by RGD
Primary source: RGD:1560358
See related: EnsemblRapid:ENSRNOG00000000397 AllianceGenome:RGD:1560358
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560358
Summary: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; nuclear receptor coactivator activity; and transcription corepressor activity. Predicted to be involved in positive regulation of cell migration; positive regulation of cell population proliferation; and regulation of DNA-templated transcription. Predicted to act upstream of or within positive regulation of apoptotic process. Predicted to be located in nuclear envelope lumen. Predicted to be active in nucleus. Orthologous to human CCAR1 (cell division cycle and apoptosis regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 104.6), Spleen (RPKM 90.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (31228624..31271233, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (30685916..30728531, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (32373443..32416044, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope lumen	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cell division cycle and apoptosis regulator protein 1

Names: cell division cycle and apoptosis regulator protein 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108535.1 → NP_001102005.1 cell division cycle and apoptosis regulator protein 1 isoform 1

See identical proteins and their annotated locations for NP_001102005.1

Status: PROVISIONAL

Source sequence(s)

CH474016

UniProtKB/TrEMBL

A0A8I6A183, A6K465

Related

ENSRNOP00000085003.1, ENSRNOT00000097504.2

Conserved Domains (6) summary

smart00513
Location:634 → 667

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

PHA03356
Location:278 → 310

PHA03356; tegument protein UL11; Provisional

pfam13499
Location:922 → 988

EF-hand_7; EF-hand domain pair

pfam14443
Location:479 → 598

DBC1; DBC1

pfam14444
Location:149 → 201

S1-like; S1-like

cl01797
Location:935 → 1099

DUF2258; Uncharacterized protein conserved in archaea (DUF2258)
NM_001434643.1 → NP_001421572.1 cell division cycle and apoptosis regulator protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0A8I6A183, D4A2P1
NM_001434644.1 → NP_001421573.1 cell division cycle and apoptosis regulator protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0A8I6A183

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

31228624..31271233 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279307.1 → XP_063135377.1 cell division cycle and apoptosis regulator protein 1 isoform X3

UniProtKB/TrEMBL

A0A8I6A183
XM_063279308.1 → XP_063135378.1 cell division cycle and apoptosis regulator protein 1 isoform X4

UniProtKB/TrEMBL

A0A8I6A183
XM_063279306.1 → XP_063135376.1 cell division cycle and apoptosis regulator protein 1 isoform X2

UniProtKB/TrEMBL

A0A8I6A183, A6K465
XM_006256463.4 → XP_006256525.1 cell division cycle and apoptosis regulator protein 1 isoform X1

See identical proteins and their annotated locations for XP_006256525.1

UniProtKB/TrEMBL

A0A8I6A183, D4A2P1

Conserved Domains (6) summary

smart00513
Location:634 → 667

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

PHA03356
Location:278 → 310

PHA03356; tegument protein UL11; Provisional

pfam13499
Location:931 → 997

EF-hand_7; EF-hand domain pair

pfam14443
Location:479 → 598

DBC1; DBC1

pfam14444
Location:149 → 201

S1-like; S1-like

cl01797
Location:944 → 1108

DUF2258; Uncharacterized protein conserved in archaea (DUF2258)
XM_063279311.1 → XP_063135381.1 cell division cycle and apoptosis regulator protein 1 isoform X6

UniProtKB/TrEMBL

A0A8I6A183
XM_039098883.2 → XP_038954811.1 cell division cycle and apoptosis regulator protein 1 isoform X3

UniProtKB/TrEMBL

A0A8I6A183

Conserved Domains (5) summary

smart00513
Location:619 → 652

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

PRK10927
Location:169 → 288

PRK10927; cell division protein FtsN

pfam14443
Location:461 → 586

DBC1

pfam14444
Location:130 → 186

S1-like

pfam15905
Location:1033 → 1138

HMMR_N; Hyaluronan mediated motility receptor N-terminal
XM_006256464.5 → XP_006256526.1 cell division cycle and apoptosis regulator protein 1 isoform X4

Conserved Domains (5) summary

PHA03356
Location:278 → 310

PHA03356; tegument protein UL11; Provisional

pfam13499
Location:869 → 935

EF-hand_7; EF-hand domain pair

pfam14443
Location:479 → 598

DBC1; DBC1

pfam14444
Location:149 → 201

S1-like; S1-like

cl01797
Location:882 → 1046

DUF2258; Uncharacterized protein conserved in archaea (DUF2258)
XM_006256462.4 → XP_006256524.1 cell division cycle and apoptosis regulator protein 1 isoform X1

Related

ENSRNOP00000059432.3, ENSRNOT00000067004.4

Conserved Domains (6) summary

smart00513
Location:634 → 667

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

PHA03356
Location:278 → 310

PHA03356; tegument protein UL11; Provisional

pfam13499
Location:931 → 997

EF-hand_7; EF-hand domain pair

pfam14443
Location:479 → 598

DBC1; DBC1

pfam14444
Location:149 → 201

S1-like; S1-like

cl01797
Location:944 → 1108

DUF2258; Uncharacterized protein conserved in archaea (DUF2258)
XM_063279309.1 → XP_063135379.1 cell division cycle and apoptosis regulator protein 1 isoform X4

UniProtKB/TrEMBL

A0A8I6A183
XM_008772894.3 → XP_008771116.1 cell division cycle and apoptosis regulator protein 1 isoform X1

See identical proteins and their annotated locations for XP_008771116.1

UniProtKB/TrEMBL

A0A8I6A183, D4A2P1

Conserved Domains (6) summary

smart00513
Location:634 → 667

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

PHA03356
Location:278 → 310

PHA03356; tegument protein UL11; Provisional

pfam13499
Location:931 → 997

EF-hand_7; EF-hand domain pair

pfam14443
Location:479 → 598

DBC1; DBC1

pfam14444
Location:149 → 201

S1-like; S1-like

cl01797
Location:944 → 1108

DUF2258; Uncharacterized protein conserved in archaea (DUF2258)
XM_063279305.1 → XP_063135375.1 cell division cycle and apoptosis regulator protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A183, D4A2P1
XM_063279304.1 → XP_063135374.1 cell division cycle and apoptosis regulator protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A183, D4A2P1
XM_063279310.1 → XP_063135380.1 cell division cycle and apoptosis regulator protein 1 isoform X5

UniProtKB/TrEMBL

A0A8I6A183
XM_063279303.1 → XP_063135373.1 cell division cycle and apoptosis regulator protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A183, D4A2P1
XM_008772897.4 → XP_008771119.1 cell division cycle and apoptosis regulator protein 1 isoform X7

UniProtKB/TrEMBL

A0A8I6A183

Conserved Domains (4) summary

smart00513
Location:442 → 475

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

PHA03356
Location:86 → 118

PHA03356; tegument protein UL11; Provisional

pfam13499
Location:739 → 805

EF-hand_7; EF-hand domain pair

pfam14443
Location:287 → 406

DBC1; DBC1