Gas8 growth arrest specific 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gas8provided by RGD
Official Full Name: growth arrest specific 8provided by RGD
Primary source: RGD:1307817
See related: EnsemblRapid:ENSRNOG00000026964 AllianceGenome:RGD:1307817
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable microtubule binding activity and small GTPase binding activity. Predicted to be involved in several processes, including flagellated sperm motility; positive regulation of protein localization to cilium; and positive regulation of smoothened signaling pathway. Predicted to act upstream of or within several processes, including brain development; determination of left/right symmetry; and epithelial cilium movement involved in extracellular fluid movement. Predicted to be located in several cellular components, including cytoskeleton; cytosol; and sperm flagellum. Predicted to be active in Golgi apparatus and microtubule. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 33. Orthologous to human GAS8 (growth arrest specific 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 19.2), Lung (RPKM 15.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (68461280..68480810)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (51552770..51572323)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (56316367..56335873)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BE106712 (e-PCR)
- UniSTS:246392

AA943006 (e-PCR)
- UniSTS:250009

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axoneme assembly	ISO Inferred from Sequence Orthology more info
involved_in axoneme assembly	ISO Inferred from Sequence Orthology more info
involved_in axoneme assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
involved_in cell motility	IEA Inferred from Electronic Annotation more info
involved_in cilium movement involved in cell motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cilium	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cilium	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smoothened signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in 9+2 motile cilium	ISO Inferred from Sequence Orthology more info
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISS Inferred from Sequence or Structural Similarity more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in motile cilium	ISO Inferred from Sequence Orthology more info
located_in motile cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dynein regulatory complex subunit 4

Names: GAS-11; GAS-8; growth arrest-specific protein 11; growth arrest-specific protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039030.1 → NP_001034119.1 dynein regulatory complex subunit 4

See identical proteins and their annotated locations for NP_001034119.1

Status: PROVISIONAL

Source sequence(s)

BC099759

UniProtKB/Swiss-Prot

Q499U4

UniProtKB/TrEMBL

A6IZY9

Related

ENSRNOP00000107041.1, ENSRNOT00000151378.1

Conserved Domains (1) summary

pfam13851
Location:221 → 420

GAS; Growth-arrest specific micro-tubule binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

68461280..68480810

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097896.2 → XP_038953824.1 dynein regulatory complex subunit 4 isoform X2

UniProtKB/TrEMBL

A0A8I5ZZT3

Related

ENSRNOP00000084663.1, ENSRNOT00000101403.2

Conserved Domains (2) summary

COG1196
Location:72 → 345

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam13851
Location:221 → 420

GAS; Growth-arrest specific micro-tubule binding
XM_006255779.5 → XP_006255841.1 dynein regulatory complex subunit 4 isoform X3

Conserved Domains (1) summary

pfam13851
Location:221 → 347

GAS; Growth-arrest specific micro-tubule binding
XM_063278166.1 → XP_063134236.1 dynein regulatory complex subunit 4 isoform X1

Related

ENSRNOP00000031180.6, ENSRNOT00000029999.8
XM_008772635.4 → XP_008770857.1 dynein regulatory complex subunit 4 isoform X4

Conserved Domains (1) summary

pfam13851
Location:66 → 265

GAS; Growth-arrest specific micro-tubule binding
XM_008772637.4 → XP_008770859.1 dynein regulatory complex subunit 4 isoform X6

Conserved Domains (1) summary

pfam13851
Location:42 → 241

GAS; Growth-arrest specific micro-tubule binding
XM_039097897.2 → XP_038953825.1 dynein regulatory complex subunit 4 isoform X4

Conserved Domains (1) summary

pfam13851
Location:66 → 265

GAS; Growth-arrest specific micro-tubule binding
XM_008772636.4 → XP_008770858.1 dynein regulatory complex subunit 4 isoform X5

Conserved Domains (1) summary

pfam13851
Location:48 → 247

GAS; Growth-arrest specific micro-tubule binding
XM_039097898.2 → XP_038953826.1 dynein regulatory complex subunit 4 isoform X6

Conserved Domains (1) summary

pfam13851
Location:42 → 241

GAS; Growth-arrest specific micro-tubule binding