Man2b1 mannosidase, alpha, class 2B, member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Man2b1provided by RGD
Official Full Name: mannosidase, alpha, class 2B, member 1provided by RGD
Primary source: RGD:3039
See related: EnsemblRapid:ENSRNOG00000023910 AllianceGenome:RGD:3039
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Manb
Summary: Enables D-mannose binding activity and alpha-mannosidase activity. Predicted to be involved in oligosaccharide catabolic process and protein modification process. Predicted to act upstream of or within learning or memory and mannose metabolic process. Predicted to be located in extracellular space and nucleoplasm. Predicted to be active in lysosomal lumen. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 516.4), Spleen (RPKM 445.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (39959964..39979299, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (23055092..23074398, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (26196797..26216981)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that hepatocyte expression of Man2a1 (Golgi apparatus alpha-mannosidase) and Man2b1 (lysosome alpha-mannosidase) is down-regulated by biological toxin swainsonine as part of locoweed/Oxytropis kansuensis hepatotoxic damage.
Title: The effects of swainsonine on the activity and expression of α-mannosidase in BRL-3A cells.

Submit: New GeneRIF Correction

General gene information

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Markers

AU047579 (e-PCR)
- UniSTS:110369

D19Rat13 (e-PCR), detects polymorphism
- UniSTS:119351

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-mannose binding	IDA Inferred from Direct Assay more info	PubMed
enables alpha-mannosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-mannosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-mannosidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alpha-mannosidase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mannose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in oligosaccharide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein modification process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal lumen	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysosomal alpha-mannosidase

Names: mannosidase 2, alpha B1; mannosidase, alpha B, lysosomal

NP_955436.1

EC 3.2.1.24

XP_006255335.1

EC 3.2.1.24

XP_038953745.1

EC 3.2.1.24

XP_038953746.1

EC 3.2.1.24

XP_063134183.1

EC 3.2.1.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199404.1 → NP_955436.1 lysosomal alpha-mannosidase precursor

See identical proteins and their annotated locations for NP_955436.1

Status: PROVISIONAL

Source sequence(s)

BC061819

UniProtKB/TrEMBL

Q6P762

Conserved Domains (2) summary

PLN02701
Location:63 → 904

PLN02701; alpha-mannosidase

cd10810
Location:63 → 340

GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

39959964..39979299 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097818.2 → XP_038953746.1 lysosomal alpha-mannosidase isoform X3

Conserved Domains (2) summary

PLN02701
Location:63 → 905

PLN02701; alpha-mannosidase

cd10810
Location:63 → 340

GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
XM_039097817.2 → XP_038953745.1 lysosomal alpha-mannosidase isoform X2

UniProtKB/TrEMBL

F7FG85

Related

ENSRNOP00000030766.4, ENSRNOT00000037699.5

Conserved Domains (2) summary

PLN02701
Location:63 → 915

PLN02701; alpha-mannosidase

cd10810
Location:63 → 351

GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
XM_006255273.5 → XP_006255335.1 lysosomal alpha-mannosidase isoform X1

Conserved Domains (3) summary

cd10810
Location:63 → 351

GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)

smart00872
Location:399 → 477

Alpha-mann_mid; Alpha mannosidase, middle domain

pfam07748
Location:617 → 1011

Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
XM_063278113.1 → XP_063134183.1 lysosomal alpha-mannosidase isoform X4