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    Mink1 misshapen-like kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303259, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mink1provided by RGD
    Official Full Name
    misshapen-like kinase 1provided by RGD
    Primary source
    RGD:1359135
    See related
    EnsemblRapid:ENSRNOG00000033508 AllianceGenome:RGD:1359135
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MEKKK 6
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including dendrite morphogenesis; neuron cellular homeostasis; and regulation of AMPA receptor activity. Is active in glutamatergic synapse and postsynapse. Orthologous to human MINK1 (misshapen like kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 281.3), Kidney (RPKM 229.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mink1 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55776879..55829406)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (55278293..55330782)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57185310..57238531)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 7, pseudogene 4 Neighboring gene phospholipase D2 Neighboring gene uncharacterized LOC134480817 Neighboring gene similar to human chromosome 17 open reading frame 107 Neighboring gene cholinergic receptor nicotinic epsilon subunit Neighboring gene glycoprotein Ib platelet subunit alpha Neighboring gene ribosomal protein L36A, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development. Dan I, et al. FEBS Lett, 2000 Mar 3. PMID 10708748
    2. MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor function. Hussain NK, et al. J Neurosci, 2010 Nov 3. PMID 21048137, Free PMC Article
    3. Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta. Hu Y, et al. J Biol Chem, 2004 Dec 24. PMID 15469942
    4. MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1. Nonaka H, et al. Biochem Biophys Res Commun, 2008 Dec 12. PMID 18930710
    5. Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes. McCarty N, et al. Nat Immunol, 2005 Jan. PMID 15608642

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in microvillus assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative thymic T cell selection ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of AMPA receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    misshapen-like kinase 1
    Names
    GCK family kinase MiNK
    MAPK/ERK kinase kinase kinase 6
    MEK kinase kinase 6
    misshapen/NIK-related kinase
    mitogen-activated protein kinase kinase kinase kinase 6
    NP_001258065.1
    NP_001401281.1
    NP_001401282.1
    XP_006246778.1
    XP_006246779.1
    XP_006246782.1
    XP_006246783.1
    XP_006246785.1
    XP_006246786.1
    XP_063125105.1
    XP_063125106.1
    XP_063125107.1
    XP_063125108.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271136.2 → NP_001258065.1  misshapen-like kinase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      F1LP90
      Conserved Domains (3) summary
      smart00036
      Location:1036 → 1334
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06636
      Location:8 → 289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

    2. NM_001414352.1 → NP_001401281.1  misshapen-like kinase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      F1LP90
      Related
      ENSRNOP00000069380.3, ENSRNOT00000086374.3

    3. NM_001414353.1 → NP_001401282.1  misshapen-like kinase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      F1LP90
      Related
      ENSRNOP00000078263.1, ENSRNOT00000109649.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      55776879..55829406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269038.1 → XP_063125108.1  misshapen-like kinase 1 isoform X10

    2. XM_006246717.5 → XP_006246779.1  misshapen-like kinase 1 isoform X2

      UniProtKB/Swiss-Prot
      F1LP90
      Conserved Domains (3) summary
      smart00036
      Location:1065 → 1363
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06636
      Location:8 → 289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

    3. XM_063269035.1 → XP_063125105.1  misshapen-like kinase 1 isoform X3

      UniProtKB/Swiss-Prot
      F1LP90

    4. XM_006246716.5 → XP_006246778.1  misshapen-like kinase 1 isoform X1

      UniProtKB/Swiss-Prot
      F1LP90
      Conserved Domains (3) summary
      smart00036
      Location:1066 → 1364
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06636
      Location:8 → 289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

    5. XM_006246721.5 → XP_006246783.1  misshapen-like kinase 1 isoform X5

      UniProtKB/Swiss-Prot
      F1LP90
      UniProtKB/TrEMBL
      A0A8I6B5X1
      Related
      ENSRNOP00000097542.1, ENSRNOT00000102912.2
      Conserved Domains (3) summary
      smart00036
      Location:1029 → 1327
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06636
      Location:8 → 289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

    6. XM_063269037.1 → XP_063125107.1  misshapen-like kinase 1 isoform X7

      UniProtKB/Swiss-Prot
      F1LP90

    7. XM_063269036.1 → XP_063125106.1  misshapen-like kinase 1 isoform X6

      UniProtKB/Swiss-Prot
      F1LP90
      UniProtKB/TrEMBL
      A0A0G2JV77

    8. XM_006246720.5 → XP_006246782.1  misshapen-like kinase 1 isoform X4

      See identical proteins and their annotated locations for XP_006246782.1

      UniProtKB/Swiss-Prot
      F1LP90
      UniProtKB/TrEMBL
      A6HG65, F1LN69
      Related
      ENSRNOP00000050929.6, ENSRNOT00000040488.7
      Conserved Domains (3) summary
      smart00036
      Location:1037 → 1335
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06636
      Location:8 → 289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

    9. XM_006246723.5 → XP_006246785.1  misshapen-like kinase 1 isoform X8

      See identical proteins and their annotated locations for XP_006246785.1

      UniProtKB/Swiss-Prot
      F1LP90
      UniProtKB/TrEMBL
      A6HG66
      Conserved Domains (3) summary
      smart00036
      Location:1000 → 1298
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06636
      Location:8 → 289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

    10. XM_006246724.5 → XP_006246786.1  misshapen-like kinase 1 isoform X9

      See identical proteins and their annotated locations for XP_006246786.1

      UniProtKB/Swiss-Prot
      F1LP90
      UniProtKB/TrEMBL
      A6HG67
      Conserved Domains (3) summary
      smart00036
      Location:992 → 1290
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06636
      Location:8 → 289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

    RNA

    1. XR_005489826.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1LP90.2 GenPept UniProtKB/Swiss-Prot:F1LP90

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