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    Ctla4 cytotoxic T-lymphocyte-associated protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 63835, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ctla4provided by RGD
    Official Full Name
    cytotoxic T-lymphocyte-associated protein 4provided by RGD
    Primary source
    RGD:61975
    See related
    EnsemblRapid:ENSRNOG00000054129 AllianceGenome:RGD:61975
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cd152; CTLA-4; sCTLA4
    Summary
    Involved in negative regulation of T cell proliferation. Predicted to be located in several cellular components, including Golgi apparatus; clathrin-coated endocytic vesicle; and perinuclear region of cytoplasm. Predicted to be part of protein complex involved in cell adhesion. Predicted to be active in external side of plasma membrane. Used to study myocarditis. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); graft-versus-host disease; hematologic cancer (multiple); kidney disease (multiple); and primary immunodeficiency disease (multiple). Orthologous to human CTLA4 (cytotoxic T-lymphocyte associated protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 27.4), Spleen (RPKM 6.8) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ctla4 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (69812859..69819959)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (62318874..62325978)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (67699397..67706068)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094692 Neighboring gene Cd28 molecule Neighboring gene inducible T-cell co-stimulator Neighboring gene proteasome 20S subunit alpha 7, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. Yang JC, et al. J Immunother, 2007 Nov-Dec. PMID 18049334, Free PMC Article
    2. CTLA-4 gene polymorphism confers susceptibility to primary biliary cirrhosis. Agarwal K, et al. J Hepatol, 2000 Apr. PMID 10782900
    3. Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells. Abrams JR, et al. J Exp Med, 2000 Sep 4. PMID 10974034, Free PMC Article
    4. The role of CTLA-4 in murine contact hypersensitivity. Nuriya S, et al. J Invest Dermatol, 2001 May. PMID 11348467
    5. Requirement of B7-mediated costimulation in the induction of experimental autoimmune anterior uveitis. Shao H, et al. Invest Ophthalmol Vis Sci, 2001 Aug. PMID 11481266

    See all (138) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effect of CTLA-4 Inhibition on Inflammation and Apoptosis After Spinal Cord Injury.
      Title: Effect of CTLA-4 Inhibition on Inflammation and Apoptosis After Spinal Cord Injury.
    2. Data suggest the potential therapeutic applications for suppression of rheumatoid arthritis (RA) by local joint delivery of CTLA4-FasL.
      Title: Intraarticular gene delivery of CTLA4-FasL suppresses experimental arthritis.
    3. observations indicate that CTLA4-FasL protein represents a significantly suppressive effect on inflammatory fibroblast-like synoviocytes' proliferation
      Title: CTLA4-FasL fusion product suppresses proliferation of fibroblast-like synoviocytes and progression of adjuvant-induced arthritis in rats.
    4. The mixed lymphocyte reaction results indicate that ex vivo transfer of AdCTLA4Ig induces antigen-specific unresponsiveness. AdCTLA4Ig perfusion did not change the proportion of CD4+25+Foxp3+ T cells in recipients' spleens.
      Title: Ex vivo transfer of adenovirus-mediated CTLA4Ig gene combined with a short course of rapamycin therapy prolongs free flap allograft survival.
    5. Tongbi Mixture 2 can inhibit T lymphocytes through down-regulating the expressions of CD28 and CD152.
      Title: [Effects of Tongbi Mixture 2 on expressions of CD28 and CD152 and content of tumor necrosis factor-alpha in peripheral blood in rats with collagen-induced arthritis].
    6. CTLA-4 plays an important suppressive role in T-cell priming and protective immunity in a prime-challenge model of acute bacterial infection.
      Title: Cytotoxic T-lymphocyte antigen 4 blockade augments the T-cell response primed by attenuated Listeria monocytogenes resulting in more rapid clearance of virulent bacterial challenge.
    7. Administration of ethyl pyruvate to inhibit HMGB1 or anti-RAGE antibody could significantly decrease expression levels of CTLA-4, Foxp3 on Tregs, and IL-10 production after burns
      Title: The effect of high-mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats.
    8. pSNAV-CTLA4Ig effectively expressed CTLA4Ig in liver allografts. CTLA4Ig improved the pathological findings after liver transplantation.
      Title: Immunological inhibition of transplanted liver allografts by adeno-associated virus vector encoding CTLA4Ig in rats.
    9. signaling through CTLA-4 is important in maintaining an immunotolerant phenotype in cardiac allografts
      Title: CTLA-4 is important in maintaining long-term survival of cardiac allografts.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of regulatory T cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein complex involved in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytotoxic T-lymphocyte protein 4
    Names
    CD152 antigen
    soluble form
    transmembrane form

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031674.1 → NP_113862.1  cytotoxic T-lymphocyte protein 4 precursor

      See identical proteins and their annotated locations for NP_113862.1

      Status: PROVISIONAL

      Source sequence(s)
      U37121
      UniProtKB/TrEMBL
      A0A096MJE4, A6IPD6, Q62859
      Related
      ENSRNOP00000073071.1, ENSRNOT00000091237.3
      Conserved Domains (2) summary
      cd05721
      Location:39 → 152
      IgV_CTLA-4; Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
      smart00410
      Location:43 → 132
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      69812859..69819959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245036.5 → XP_006245098.1  cytotoxic T-lymphocyte protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006245098.1

      UniProtKB/TrEMBL
      A6IPD7, G3V7D2, Q9Z1A7
      Related
      ENSRNOP00000069885.1, ENSRNOT00000088183.3
      Conserved Domains (2) summary
      cd05721
      Location:39 → 152
      IgV_CTLA-4; Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
      smart00410
      Location:43 → 132
      IG_like; Immunoglobulin like
    Nucleotide Protein Strain
    Heading Accession and Version

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