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    Tnfrsf25 TNF receptor superfamily member 25 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500592, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tnfrsf25provided by RGD
    Official Full Name
    TNF receptor superfamily member 25provided by RGD
    Primary source
    RGD:1598206
    See related
    EnsemblRapid:ENSRNOG00000021814 AllianceGenome:RGD:1598206
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in apoptotic process and signal transduction. Predicted to be active in plasma membrane. Orthologous to human TNFRSF25 (TNF receptor superfamily member 25). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 35.1), Spleen (RPKM 21.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tnfrsf25 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (167904377..167909052)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (162621669..162626341)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (169288419..169293137)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene nucleolar protein 9 Neighboring gene pleckstrin homology and RhoGEF domain containing G5 Neighboring gene espin Neighboring gene hes family bHLH transcription factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Migone TS, et al. Immunity, 2002 Mar. PMID 11911831
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 25
    Names
    tumor necrosis factor receptor superfamily, member 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001137644.1 → NP_001131116.1  tumor necrosis factor receptor superfamily member 25 precursor

      See identical proteins and their annotated locations for NP_001131116.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A0A8I5ZZ87, A6IUG8, A6IUG9, D4ADP7
      Related
      ENSRNOP00000052331.2, ENSRNOT00000055466.4
      Conserved Domains (2) summary
      cd13420
      Location:37 → 147
      TNFRSF25; tumor necrosis factor receptor superfamily member 25 (TNFRSF25), also known as death receptor 3 (DR3)
      cl14633
      Location:324 → 400
      DD; Death Domain Superfamily of protein-protein interaction domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      167904377..167909052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239473.5 → XP_006239535.1  tumor necrosis factor receptor superfamily member 25 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZ87, A6IUG9
      Related
      ENSRNOP00000109588.1, ENSRNOT00000149119.1
      Conserved Domains (2) summary
      cd13420
      Location:51 → 161
      TNFRSF25; tumor necrosis factor receptor superfamily member 25 (TNFRSF25), also known as death receptor 3 (DR3)
      cl14633
      Location:338 → 414
      DD; Death Domain Superfamily of protein-protein interaction domains

    2. XM_006239474.5 → XP_006239536.1  tumor necrosis factor receptor superfamily member 25 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZ87, A6IUG9
      Conserved Domains (2) summary
      cd13420
      Location:51 → 161
      TNFRSF25; tumor necrosis factor receptor superfamily member 25 (TNFRSF25), also known as death receptor 3 (DR3)
      cl14633
      Location:337 → 413
      DD; Death Domain Superfamily of protein-protein interaction domains

    3. XM_039110651.2 → XP_038966579.1  tumor necrosis factor receptor superfamily member 25 isoform X3

      Conserved Domains (2) summary
      cd00185
      Location:54 → 89
      TNFRSF; CRD1 [structural motif]
      cl22855
      Location:51 → 161
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    Nucleotide Protein Strain
    Heading Accession and Version

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