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    Lsm10 LSM10, U7 small nuclear RNA associated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366468, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lsm10provided by RGD
    Official Full Name
    LSM10, U7 small nuclear RNA associatedprovided by RGD
    Primary source
    RGD:1584914
    See related
    EnsemblRapid:ENSRNOG00000026978 AllianceGenome:RGD:1584914
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable U7 snRNA binding activity and histone pre-mRNA DCP binding activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be located in Cajal body. Predicted to be part of U7 snRNP and cytoplasmic U snRNP body. Predicted to be active in nuclear body. Orthologous to human LSM10 (LSM10, U7 small nuclear RNA associated). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 45.1), Adrenal (RPKM 35.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Lsm10 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (143649817..143660391)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (138365983..138375856)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (144106339..144108703)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S15 Neighboring gene organic solute carrier partner 1 Neighboring gene ribosomal protein S14, pseudogene 7 Neighboring gene serine/threonine kinase 40 Neighboring gene uncharacterized LOC108351032

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables U7 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables U7 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone pre-mRNA DCP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone pre-mRNA DCP binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U7 snRNP ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytoplasmic U snRNP body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    U7 snRNA-associated Sm-like protein LSm10
    Names
    U7 snRNP-specific Sm-like protein LSM10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108976.1NP_001102446.1  U7 snRNA-associated Sm-like protein LSm10

      See identical proteins and their annotated locations for NP_001102446.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A6IS89, A6IS90, B2RYU1
      Related
      ENSRNOP00000106481.1, ENSRNOT00000162109.1
      Conserved Domains (1) summary
      cd01733
      Location:885
      LSm10; Like-Sm protein 10

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      143649817..143660391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238897.4XP_006238959.1  U7 snRNA-associated Sm-like protein LSm10 isoform X1

      See identical proteins and their annotated locations for XP_006238959.1

      UniProtKB/TrEMBL
      A6IS89, A6IS90, B2RYU1
      Conserved Domains (1) summary
      cd01733
      Location:885
      LSm10; Like-Sm protein 10
    2. XM_017593541.3XP_017449030.1  U7 snRNA-associated Sm-like protein LSm10 isoform X1

      UniProtKB/TrEMBL
      A6IS89, A6IS90, B2RYU1
      Conserved Domains (1) summary
      cd01733
      Location:885
      LSm10; Like-Sm protein 10
    3. XM_006238895.5XP_006238957.1  U7 snRNA-associated Sm-like protein LSm10 isoform X1

      See identical proteins and their annotated locations for XP_006238957.1

      UniProtKB/TrEMBL
      A6IS89, A6IS90, B2RYU1
      Conserved Domains (1) summary
      cd01733
      Location:885
      LSm10; Like-Sm protein 10
    4. XM_063288119.1XP_063144189.1  U7 snRNA-associated Sm-like protein LSm10 isoform X1

      UniProtKB/TrEMBL
      A6IS89, A6IS90, B2RYU1