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    Rpl18 ribosomal protein L18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81766, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rpl18provided by RGD
    Official Full Name
    ribosomal protein L18provided by RGD
    Primary source
    RGD:621182
    See related
    EnsemblRapid:ENSRNOG00000021035 AllianceGenome:RGD:621182
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Involved in liver regeneration. Part of cytosolic large ribosomal subunit. Is active in synapse. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 18. Orthologous to human RPL18 (ribosomal protein L18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 1788.1), Thymus (RPKM 1549.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rpl18 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105325269..105327911)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96188811..96191452)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101700910..101703551)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene D-box binding PAR bZIP transcription factor Neighboring gene sphingosine kinase 2 Neighboring gene family with sequence similarity 83, member E Neighboring gene sperm acrosome associated 4 Neighboring gene sulfotransferase family 2B member 1 Neighboring gene uncharacterized LOC134483107

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The primary structure of rat ribosomal protein L18. Devi KR, et al. DNA, 1988 Apr. PMID 3371159
    2. Differential expression of diacylglycerol kinase iota and L18A mRNAs in the brains of alcohol-preferring AA and alcohol-avoiding ANA rats. Sommer W, et al. Mol Psychiatry, 2001 Jan. PMID 11244494
    3. Coordinate regulation of ribosomal protein mRNA level in regenerating rat liver. Study with the corresponding mouse cloned cDNAs. Faliks D, et al. Nucleic Acids Res, 1982 Feb 11. PMID 6121318, Free PMC Article
    4. Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry. Peng J, et al. J Biol Chem, 2004 May 14. PMID 15020595
    5. Selective high-efficiency cross-linking of mammalian ribosomal proteins with cleavable thiol-directed heterobifunctional reagents: identification and binding directions of major protein complexes. Hultin T. Biochim Biophys Acta, 1986 Aug 15. PMID 3730400

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in liver regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation at postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation at presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL18
    Names
    60S ribosomal protein L18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031102.2 → NP_112364.1  large ribosomal subunit protein eL18

      See identical proteins and their annotated locations for NP_112364.1

      Status: VALIDATED

      Source sequence(s)
      BC084727, CB577548
      UniProtKB/Swiss-Prot
      P12001
      UniProtKB/TrEMBL
      A6JB77, Q0QEW8
      Related
      ENSRNOP00000077861.2, ENSRNOT00000097220.2
      Conserved Domains (1) summary
      pfam17135
      Location:2 → 176
      Ribosomal_L18; Ribosomal protein 60S L18 and 50S L18e

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      105325269..105327911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229161.5 → XP_006229223.1  large ribosomal subunit protein eL18 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4M9, Q0QEW8
      Related
      ENSRNOP00000088224.1, ENSRNOT00000116041.2
      Conserved Domains (1) summary
      cl12022
      Location:16 → 192
      Ribosomal_L18e; Ribosomal protein L18e/L15
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12001.2 GenPept UniProtKB/Swiss-Prot:P12001

    Gene LinkOut

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