Dop1R1 Dopamine 1-like receptor 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dop1R1provided by FlyBase
Official Full Name: Dopamine 1-like receptor 1provided by FlyBase
Primary source: FLYBASE:FBgn0011582
Locus tag: Dmel_CG9652
See related: AllianceGenome:FB:FBgn0011582
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9652; D-Dop1; D1R1; DA1; dDA1; dDA1/DmDOP1; Dmdop1; DmDop1; DmDOP1; Dmel\CG9652; Dop1-R1; Dop1R; DOP1R1; dopr; DopR; DopR1; DopR35F; DR1; DRD1; dumb; Dumb
Summary: Enables dopamine neurotransmitter receptor activity, coupled via Gs. Involved in several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; learning or memory; and regulation of olfactory learning. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane. Is expressed in several structures, including Tvb neurons; adult ellipsoid body R-neuron; ganglia; synaptic neuropil domain; and synaptic neuropil subdomain. Used to study alcohol use disorder and depressive disorder. Human ortholog(s) of this gene implicated in Parkinson's disease; attention deficit hyperactivity disorder; blepharospasm; hypertension; and kidney failure. Orthologous to human DRD1 (dopamine receptor D1) and DRD5 (dopamine receptor D5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 88A10-88A12; 3-54 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (14165379..14214810, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (9991101..10040532, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Voluntary intake of psychoactive substances is regulated by the dopamine receptor Dop1R1 in Drosophila.
Title: Voluntary intake of psychoactive substances is regulated by the dopamine receptor Dop1R1 in Drosophila.
Results confirm a role for DopR1 in promoting water consumption in drosophila and found DopR1 expression in the mushroom body was sufficient to drive consumption and enhance water taste sensitivity.
Title: A simple high throughput assay to evaluate water consumption in the fruit fly.
It is concluded that the activating effect of dopamine on JH(juvenile hormone) synthesis in Drosophila is mediated by D1-like receptors
Title: [Role of DopR in the molecular mechanism of the dopamine control of juvenile hormone metabolism in female Drosophila].
a dopamine D1-like receptor, DopR, was involved in fly courtship behavior. DopR mutant male flies display male-male courtship behavior.
Title: Mutation of Drosophila dopamine receptor DopR leads to male-male courtship behavior.
Juvenile hormone synthesis is stimulated by activation of dopamine D1-like receptors in Drosophila.
Title: Juvenile hormone synthesis is stimulated by activation of dopamine D1-like receptors in Drosophila.
Loss-of-function mutations in the D1 dopamine receptor DopR enhance repetitive startle-induced arousal while decreasing sleep-wake arousal.
Title: Two different forms of arousal in Drosophila are oppositely regulated by the dopamine D1 receptor ortholog DopR via distinct neural circuits.
This review provides evidence that dopamine D1 receptor DopR is involved in several types of attentional processes and independently regulates distinct types of arousal.
Title: Attention K-Mart shoppers: blowout on Aisle 7!
All our data demonstrated that activation of D1-like receptors in Drosophila neurons negatively modulates excitatory cholinergic synaptic transmission and thus inhibits neuronal excitability.
Title: Suppression of excitatory cholinergic synaptic transmission by Drosophila dopamine D1-like receptors.
D1 dopamine receptor dDA1 is required in the mushroom body neurons for aversive and appetitive learning in Drosophila.
Title: D1 dopamine receptor dDA1 is required in the mushroom body neurons for aversive and appetitive learning in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables dopamine neurotransmitter receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables dopamine neurotransmitter receptor activity, coupled via Gs	IDA Inferred from Direct Assay more info	PubMed
enables dopamine neurotransmitter receptor activity, coupled via Gs	IMP Inferred from Mutant Phenotype more info	PubMed
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled dopamine receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to sucrose stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to odorant	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to sucrose	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISM Inferred from Sequence Model more info	PubMed

General protein information

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Preferred Names: dopamine 1-like receptor 1

Names: CG9652-PB; CG9652-PC; CG9652-PD; CG9652-PE; CG9652-PF; D1 dopamine receptor; D1-Like dopamine receptor; D1-like DA receptor; D1-like receptor; DA D[[1]]-like receptor; D[[1]] dopamine receptor; Dop1R1-PB; Dop1R1-PC; Dop1R1-PD; Dop1R1-PE; Dop1R1-PF; dDA1; dopamine 1 receptor; dopamine D1 receptor; dopamine D1-like receptor; dopamine receptor; dopaminergic receptor; dumb; dumb DA receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

14165379..14214810 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001260163.1 → NP_001247092.1 dopamine 1-like receptor 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247092.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4VCK3, E1JIK5, P41596, Q24038, Q9VFM1, S4X4E2

UniProtKB/TrEMBL

A0A0B4K6H0

Conserved Domains (2) summary

pfam00001
Location:160 → 446

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:150 → 281

7tm_4; Olfactory receptor
NM_001170136.2 → NP_001163607.1 dopamine 1-like receptor 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163607.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P41596

Conserved Domains (1) summary

cd15065
Location:115 → 427

7tmA_Ap5-HTB1-like; serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors
NM_057659.4 → NP_477007.2 dopamine 1-like receptor 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477007.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P41596

Conserved Domains (1) summary

cd15065
Location:130 → 442

7tmA_Ap5-HTB1-like; serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001275634.1 → NP_001262563.1 dopamine 1-like receptor 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262563.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHI2

Conserved Domains (2) summary

pfam00001
Location:145 → 431

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:134 → 266

7tm_4; Olfactory receptor
NM_001316525.1 → NP_001303454.1 dopamine 1-like receptor 1, isoform F [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A126GUU2

Conserved Domains (2) summary

pfam00001
Location:145 → 431

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:134 → 266

7tm_4; Olfactory receptor