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    sumo1 small ubiquitin like modifier 1 [ Danio rerio (zebrafish) ]

    Gene ID: 406438, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sumo1provided by ZNC
    Official Full Name
    small ubiquitin like modifier 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2186
    See related
    Ensembl:ENSDARG00000044267 AllianceGenome:ZFIN:ZDB-GENE-040426-2186
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fd12c02; zgc:65934; zgc:85634; hm:zeh0670; wu:fb74c02; wu:fd12c02
    Summary
    Predicted to enable protein tag activity and ubiquitin-like protein ligase binding activity. Acts upstream of or within chordate embryonic development and definitive hemopoiesis. Predicted to be located in nuclear stress granule. Predicted to be active in nucleus. Predicted to colocalize with PML body. Is expressed in brain; cranial neural crest cell; digestive system; eye; and pectoral fin bud. Human ortholog(s) of this gene implicated in orofacial cleft 10. Orthologous to several human genes including SUMO1 (small ubiquitin like modifier 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sumo1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (9677450..9688511)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (9441911..9452972)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD11B Neighboring gene small nucleolar RNA SNORD70 Neighboring gene NOP58 ribonucleoprotein homolog (yeast) Neighboring gene frizzled class receptor 7b Neighboring gene cyclin-dependent kinase 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression analysis of small ubiquitin-like modifier (SUMO) genes from grouper (Epinephelus coioides). Xu M, et al. Fish Shellfish Immunol, 2016 Jan. PMID 26616235
    2. The tumor-associated YB-1 protein: new player in the circadian control of cell proliferation. Pagano C, et al. Oncotarget, 2017 Jan 24. PMID 28008157, Free PMC Article
    3. Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish. Yuan H, et al. Cell Res, 2010 Feb. PMID 19704416
    4. Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish. Yuan H, et al. Sci Rep, 2015 Mar 11. PMID 25757417, Free PMC Article
    5. GATA5 SUMOylation is indispensable for zebrafish cardiac development. Wen B, et al. Biochim Biophys Acta Gen Subj, 2017 Jul. PMID 28285006

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to cadmium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within chordate embryonic development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within definitive hemopoiesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    small ubiquitin-related modifier 1
    Names
    SUMO-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213159.1 → NP_998324.1  small ubiquitin-related modifier 1

      See identical proteins and their annotated locations for NP_998324.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056283
      UniProtKB/Swiss-Prot
      Q7SZR5
      Related
      ENSDARP00000064994.5, ENSDART00000064995.6
      Conserved Domains (2) summary
      cd01763
      Location:10 → 96
      Sumo; Small ubiquitin-related modifier (SUMO)
      smart00213
      Location:21 → 92
      UBQ; Ubiquitin homologues

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      9677450..9688511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7SZR5.1 GenPept UniProtKB/Swiss-Prot:Q7SZR5

    Gene LinkOut

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