trpa1b transient receptor potential cation channel, subfamily A, member 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: trpa1bprovided by ZNC
Official Full Name: transient receptor potential cation channel, subfamily A, member 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050106-1
See related: Ensembl:ENSDARG00000031875 AllianceGenome:ZFIN:ZDB-GENE-050106-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: trpa2; trpa1l
Summary: Enables intracellularly gated calcium channel activity. Acts upstream of or within chemosensory behavior; detection of chemical stimulus involved in sensory perception of pain; and monoatomic ion transmembrane transport. Predicted to be located in membrane. Is expressed in Rohon-Beard neurons and cranial ganglion. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 1. Orthologous to human TRPA1 (transient receptor potential cation channel subfamily A member 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (13635357..13714108)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (13490941..13569700)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High-throughput behavioral analyses of trpa1a and trpa1b mutant larvae indicate that TRPA1b is necessary for behavioral responses to chemical irritants.
Title: Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables channel activity	IDA Inferred from Direct Assay more info	PubMed
enables intracellularly gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables mechanosensitive monoatomic ion channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chemosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of chemical stimulus involved in sensory perception	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within detection of chemical stimulus involved in sensory perception of pain	IGI Inferred from Genetic Interaction more info	PubMed
NOT acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception	ISS Inferred from Sequence or Structural Similarity more info	PubMed
NOT acts_upstream_of_or_within detection of temperature stimulus involved in thermoception	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within response to fatty acid	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sensory perception of chemical stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: transient receptor potential cation channel subfamily A member 1b

Names: transient receptor potential cation channel subfamily A member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007066.2 → NP_001007067.1 transient receptor potential cation channel subfamily A member 1b

See identical proteins and their annotated locations for NP_001007067.1

Status: PROVISIONAL

Source sequence(s)

AY677197

UniProtKB/TrEMBL

A0A8M9PU11, Q5UM14

Related

ENSDARP00000096775.2, ENSDART00000105997.4

Conserved Domains (4) summary

cd00204
Location:488 → 605

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00520
Location:803 → 977

Ion_trans; Ion transport protein

pfam12796
Location:495 → 587

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:491 → 520

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007135.7 Reference GRCz11 Primary Assembly

Range

13635357..13714108

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009297331.4 → XP_009295606.1 transient receptor potential cation channel subfamily A member 1b isoform X1

See identical proteins and their annotated locations for XP_009295606.1

UniProtKB/TrEMBL

A0A8M3ANH4, A0A8M9PU11, B6D5I5

Related

ENSDARP00000145424.1, ENSDART00000183008.1

Conserved Domains (4) summary

cd00204
Location:475 → 592

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00520
Location:790 → 964

Ion_trans; Ion transport protein

pfam12796
Location:482 → 574

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:478 → 507

ANK; ANK repeat [structural motif]