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    DNTT DNA nucleotidylexotransferase [ Gallus gallus (chicken) ]

    Gene ID: 396351, updated on 10-Oct-2024

    Summary

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    Symbol
    DNTTprovided by CGNC
    Full Name
    DNA nucleotidylexotransferaseprovided by CGNC
    Primary source
    CGNC:5270
    See related
    Ensembl:ENSGALG00010021672
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    TDT
    Orthologs
    human mouse all
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    Genomic context

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    See DNTT in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (21976196..22086355)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (21867265..21977425)

    Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100859611 Neighboring gene zinc finger protein 518A Neighboring gene cyclin J Neighboring gene SH2 domain containing 6 Neighboring gene heparan sulfate glucosamine 3-O-sulfotransferase 1-like Neighboring gene uncharacterized LOC121113371 Neighboring gene VENT homeobox Neighboring gene microRNA 202

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. T-cell specific avian TdT: characterization of the cDNA and recombinant enzyme. Yang B, et al. Nucleic Acids Res, 1995 Jun 11. PMID 7596835, Free PMC Article
    2. Mutational analysis of residues in the nucleotide binding domain of human terminal deoxynucleotidyl transferase. Yang B, et al. J Biol Chem, 1994 Apr 22. PMID 8163485
    3. Chicken blastoderms and primordial germ cells possess a higher expression of DNA repair genes and lower expression of apoptosis genes to preserve their genome stability. Rengaraj D, et al. Sci Rep, 2022 Jan 7. PMID 34997179, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNTT shows higher fold expression primarily in EGK.X blastoderms and secondarily in primordial germ cells compared to chicken embryonic fibroblasts.
      Title: Chicken blastoderms and primordial germ cells possess a higher expression of DNA repair genes and lower expression of apoptosis genes to preserve their genome stability.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA nucleotidylexotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair via nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA nucleotidylexotransferase
    Names
    deoxynucleotidyltransferase, terminal
    terminal addition enzyme
    terminal deoxynucleotidyl transferase
    terminal deoxynucleotidyltransferase
    terminal transferase
    NP_990720.3
    XP_040558241.1
    XP_046775914.1
    XP_046775915.1
    XP_046798725.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205389.3 → NP_990720.3  DNA nucleotidylexotransferase

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000232
      UniProtKB/Swiss-Prot
      P36195
      Related
      ENSGALP00010031565.1, ENSGALT00010052659.1
      Conserved Domains (2) summary
      smart00483
      Location:163 → 513
      POLXc; DNA polymerase X family
      cd18443
      Location:31 → 125
      BRCT_DNTT; BRCT domain of DNA nucleotidylexotransferase (DNTT) and similar proteins

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      21976196..22086355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046942769.1 → XP_046798725.1  DNA nucleotidylexotransferase isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZL84
      Related
      ENSGALP00010031556.1, ENSGALT00010052651.1

    2. XM_040702307.2 → XP_040558241.1  DNA nucleotidylexotransferase isoform X2

      UniProtKB/Swiss-Prot
      P36195
      Conserved Domains (2) summary
      smart00483
      Location:166 → 432
      POLXc; DNA polymerase X family
      cd18443
      Location:31 → 125
      BRCT_DNTT; BRCT domain of DNA nucleotidylexotransferase (DNTT) and similar proteins

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      21867265..21977425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046919958.1 → XP_046775914.1  DNA nucleotidylexotransferase isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZL84

    2. XM_046919959.1 → XP_046775915.1  DNA nucleotidylexotransferase isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36195.1 GenPept UniProtKB/Swiss-Prot:P36195

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials