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    RpS3 Ribosomal protein S3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42761, updated on 4-Jan-2025

    Summary

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    Official Symbol
    RpS3provided by FlyBase
    Official Full Name
    Ribosomal protein S3provided by FlyBase
    Primary source
    FLYBASE:FBgn0002622
    Locus tag
    Dmel_CG6779
    See related
    AllianceGenome:FB:FBgn0002622
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    6779; CG6779; chr3R:19185518..19185701; Dmel\CG6779; DmRpS3; dS3; IP15838p; M; M(3)124; M(3)95A; M(3)B; M(3)B2; M(3)Fla; M(3)w; M(3R)w; M95A; Mw; M[[w]]; Rp S3; rps3; rpS3; Rps3; RPS3; RS3; S3; X72921
    Summary
    Enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity; oxidized purine DNA binding activity; and oxidized purine nucleobase lesion DNA N-glycosylase activity. A structural constituent of ribosome. Involved in DNA repair and negative regulation of neuron apoptotic process. Located in cytosolic ribosome and nuclear matrix. Is expressed in adult head; adult heart; organism; and ovary. Used to study intrinsic cardiomyopathy. Orthologous to human RPS3 (ribosomal protein S3). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See RpS3 in Genome Data Viewer
    Location:
    94E13-94E13; 3-78 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23358812..23360207)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19184534..19185929)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ATP synthase, coupling factor 6 Neighboring gene Secretory 13 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44322

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conversion of the bifunctional 8-oxoguanine/beta-delta apurinic/apyrimidinic DNA repair activities of Drosophila ribosomal protein S3 into the human S3 monofunctional beta-elimination catalyst through a single amino acid change. Hegde V, et al. J Biol Chem, 2001 Jul 20. PMID 11353770
    2. RpS3 Is Required for Spermatogenesis of Drosophila melanogaster. Fang Y, et al. Cells, 2023 Feb 10. PMID 36831240, Free PMC Article
    3. The Drosophila S3 multifunctional DNA repair/ribosomal protein protects Fanconi anemia cells against oxidative DNA damaging agents. Kelley MR, et al. Mutat Res, 2001 Mar 7. PMID 11182542
    4. Ribosomal protein insufficiency and the minute syndrome in Drosophila: a dose-response relationship. Saebøe-Larssen S, et al. Genetics, 1998 Mar. PMID 9539436, Free PMC Article
    5. Characterization and mechanism of action of Drosophila ribosomal protein S3 DNA glycosylase activity for the removal of oxidatively damaged DNA bases. Deutsch WA, et al. J Biol Chem, 1997 Dec 26. PMID 9407063

    See all (177) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RpS3 Is Required for Spermatogenesis of Drosophila melanogaster.
      Title: RpS3 Is Required for Spermatogenesis of Drosophila melanogaster.
    2. Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status.
      Title: Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status.
    3. dOgg1 and RpS3 in mitochondria increase cell survival after exposure to the nitric oxide donor SNAP
      Title: Effects of ectopic expression of Drosophila DNA glycosylases dOgg1 and RpS3 in mitochondria.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidized purine DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidized purine nucleobase lesion DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome HDA PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic cell cycle HMP PubMed 
    involved_in negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosolic ribosome HDA PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of small ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein S3
    Names
    CG6779-PA
    CG6779-PB
    Minute(3)95A
    RpS3-PA
    RpS3-PB
    minute
    rps3 gene
    NP_001287481.1
    NP_476632.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23358812..23360207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300552.1 → NP_001287481.1  ribosomal protein S3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287481.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q06559, Q9VCM9
      UniProtKB/TrEMBL
      G3M3A2, Q29QY2
      Conserved Domains (1) summary
      PTZ00084
      Location:6 → 222
      PTZ00084; 40S ribosomal protein S3; Provisional

    2. NM_057284.6 → NP_476632.1  ribosomal protein S3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476632.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q06559, Q9VCM9
      UniProtKB/TrEMBL
      G3M3A2, Q29QY2
      Related
      FBpp0083802
      Conserved Domains (1) summary
      PTZ00084
      Location:6 → 222
      PTZ00084; 40S ribosomal protein S3; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3M3A2 G3M3A2
    Q06559.1 Q06559

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