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    Ptger1 prostaglandin E receptor 1 (subtype EP1) [ Mus musculus (house mouse) ]

    Gene ID: 19216, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptger1provided by MGI
    Official Full Name
    prostaglandin E receptor 1 (subtype EP1)provided by MGI
    Primary source
    MGI:MGI:97793
    See related
    Ensembl:ENSMUSG00000019464 AllianceGenome:MGI:97793
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EP1; Ptgerep1
    Summary
    Enables D1 dopamine receptor binding activity. Involved in adenylate cyclase-activating dopamine receptor signaling pathway. Acts upstream of or within response to lipopolysaccharide. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Orthologous to human PTGER1 (prostaglandin E receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 44.9), spleen adult (RPKM 41.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ptger1 in Genome Data Viewer
    Location:
    8 C2; 8 40.22 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84393171..84399385)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83666644..83672756)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B1 Neighboring gene STARR-seq mESC enhancer starr_22093 Neighboring gene STARR-positive B cell enhancer ABC_E1372 Neighboring gene STARR-positive B cell enhancer ABC_E11744 Neighboring gene GIPC PDZ domain containing family, member 1 Neighboring gene protein kinase N1 Neighboring gene STARR-positive B cell enhancer ABC_E9319 Neighboring gene STARR-seq mESC enhancer starr_22095 Neighboring gene STARR-positive B cell enhancer ABC_E562 Neighboring gene DEAD box helicase 39a Neighboring gene microRNA 1668 Neighboring gene adhesion G protein-coupled receptor E5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86260655-86260859 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86263836-86264037 Neighboring gene predicted gene, 46046

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D1 dopamine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables prostaglandin E receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables prostaglandin E receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables prostaglandin E receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    prostaglandin E2 receptor EP1 subtype
    Names
    PGE receptor EP1 subtype
    PGE2 receptor EP1 subtype
    prostanoid EP1 receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013641.3NP_038669.1  prostaglandin E2 receptor EP1 subtype

      See identical proteins and their annotated locations for NP_038669.1

      Status: VALIDATED

      Source sequence(s)
      AC164432, AK053616, AK164746
      Consensus CDS
      CCDS22458.1
      UniProtKB/Swiss-Prot
      P35375
      UniProtKB/TrEMBL
      B2RS62
      Related
      ENSMUSP00000019608.6, ENSMUST00000019608.7
      Conserved Domains (1) summary
      pfam00001
      Location:302354
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      84393171..84399385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530771.5XP_006530834.1  prostaglandin E2 receptor EP1 subtype isoform X1

      Conserved Domains (2) summary
      cd14964
      Location:7096
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:69394
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily