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    MICU1 mitochondrial calcium uptake 1 [ Sus scrofa (pig) ]

    Gene ID: 100155980, updated on 3-Dec-2024

    Summary

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    Official Symbol
    MICU1provided by VGNC
    Official Full Name
    mitochondrial calcium uptake 1provided by VGNC
    Primary source
    VGNC:VGNC:90211
    See related
    Ensembl:ENSSSCG00000010289
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Ubiquitous expression in psoas major muscle (RPKM 32.1), longissimus dorsi muscle (RPKM 25.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See MICU1 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 14 NC_010456.5 (75203731..75445628, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 14 NC_010456.4 (81253348..81512159, complement)

    Chromosome 14 - NC_010456.5Genomic Context describing neighboring genes Neighboring gene DNA damage inducible transcript 4 Neighboring gene DnaJ heat shock protein family (Hsp40) member B12 Neighboring gene splicing factor 3B subunit 4-like Neighboring gene mitochondrial calcium uniporter Neighboring gene oncoprotein induced transcript 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium import into the mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitochondrial calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of uniplex complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcium uptake protein 1, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243605.1 → NP_001230534.1  calcium uptake protein 1, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      AK236596, BP144207, BX916404, CN152976, CO954363, DN117270
      UniProtKB/TrEMBL
      A0A8D0IRX9
      Conserved Domains (1) summary
      pfam13202
      Location:226 → 249
      EF-hand_5; EF hand

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010456.5 Reference Sscrofa11.1 Primary Assembly

      Range
      75203731..75445628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021071962.1 → XP_020927621.1  calcium uptake protein 1, mitochondrial isoform X8

      UniProtKB/TrEMBL
      A0A8D0IRX9
      Conserved Domains (2) summary
      cd16173
      Location:172 → 417
      EFh_MICU1; EF-hand, calcium binding motif, found in calcium uptake protein 1, mitochondrial (MICU1) and similar proteins
      cl08302
      Location:149 → 193
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. XM_005671068.3 → XP_005671125.1  calcium uptake protein 1, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A287AXE8, A0A8D0IRX9
      Conserved Domains (1) summary
      pfam13202
      Location:226 → 249
      EF-hand_5; EF hand

    3. XM_005671070.3 → XP_005671127.1  calcium uptake protein 1, mitochondrial isoform X7

      UniProtKB/TrEMBL
      A0A8D0IRX9
      Conserved Domains (1) summary
      pfam13202
      Location:228 → 251
      EF-hand_5; EF hand

    4. XM_005671067.3 → XP_005671124.1  calcium uptake protein 1, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A8D0IRX9
      Conserved Domains (1) summary
      pfam13202
      Location:228 → 251
      EF-hand_5; EF hand

    5. XM_005671069.3 → XP_005671126.1  calcium uptake protein 1, mitochondrial isoform X6

      UniProtKB/TrEMBL
      A0A8D0IRX9, A0A8D0ISJ9, A0A8D0TLK8, F1SU87
      Related
      ENSSSCP00000010969.4, ENSSSCT00000011261.5
      Conserved Domains (1) summary
      pfam13202
      Location:230 → 253
      EF-hand_5; EF hand

    6. XM_021071959.1 → XP_020927618.1  calcium uptake protein 1, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8D0IRX9
      Conserved Domains (2) summary
      cd15900
      Location:229 → 258
      EFh_MICU; EF-hand motif [structural motif]
      cl28896
      Location:229 → 474
      EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins

    7. XM_021071961.1 → XP_020927620.1  calcium uptake protein 1, mitochondrial isoform X5

      UniProtKB/TrEMBL
      A0A286ZLA2, A0A8D0IN84, A0A8D0IRX9
      Related
      ENSSSCP00000032388.3, ENSSSCT00000050834.3
      Conserved Domains (1) summary
      cd16173
      Location:231 → 450
      EFh_MICU1; EF-hand, calcium binding motif, found in calcium uptake protein 1, mitochondrial (MICU1) and similar proteins

    8. XM_021071958.1 → XP_020927617.1  calcium uptake protein 1, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8D0IRX9
      Conserved Domains (2) summary
      cd15900
      Location:231 → 260
      EFh_MICU; EF-hand motif [structural motif]
      cl28896
      Location:231 → 476
      EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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