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    NRP1 neuropilin 1 [ Macaca fascicularis (crab-eating macaque) ]

    Gene ID: 102145235, updated on 12-Jun-2024

    Summary

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    Gene symbol
    NRP1
    Gene description
    neuropilin 1
    See related
    Ensembl:ENSMFAG00000032756
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca fascicularis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See NRP1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_05 current T2T-MFA8v1.0 (GCF_037993035.1) 9 NC_088383.1 (33930857..34088523, complement)
    102 previous assembly MFA1912RKSv2 (GCF_012559485.2) 9 NC_052263.1 (32891301..33048814, complement)

    Chromosome 9 - NC_088383.1Genomic Context describing neighboring genes Neighboring gene integrin subunit beta 1 Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene uncharacterized LOC135964936 Neighboring gene uncharacterized LOC102146868

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables semaphorin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables vascular endothelial growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables vascular endothelial growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neural crest cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of filopodium assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of vascular endothelial growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to wounding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuropilin-1
    Names
    Vascular endothelial cell growth factor 165 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_037993035.1-RS_2024_05

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference T2T-MFA8v1.0

    Genomic

    1. NC_088383.1 Reference T2T-MFA8v1.0

      Range
      33930857..34088523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005564935.4 → XP_005564992.1  neuropilin-1 isoform X1

      See identical proteins and their annotated locations for XP_005564992.1

      UniProtKB/TrEMBL
      A0A2K5V5B8, A0A2K5V5E7
      Related
      ENSMFAP00000019923.1
      Conserved Domains (4) summary
      cd00041
      Location:27 → 140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277 → 423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam11980
      Location:845 → 923
      DUF3481; C-terminal domain of neuropilin glycoprotein
      pfam00629
      Location:650 → 810
      MAM; MAM domain, meprin/A5/mu

    2. XM_005564939.4 → XP_005564996.1  neuropilin-1 isoform X4

      UniProtKB/TrEMBL
      A0A2K5V5E7
      Related
      ENSMFAP00000019928.1
      Conserved Domains (6) summary
      cd06263
      Location:615 → 768
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:808 → 885
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:610 → 769
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:274 → 424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27 → 140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277 → 423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    3. XM_005564937.4 → XP_005564994.1  neuropilin-1 isoform X2

      UniProtKB/TrEMBL
      A0A2K5V5E7
      Conserved Domains (6) summary
      cd06263
      Location:643 → 796
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:836 → 913
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:638 → 797
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:274 → 424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27 → 140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277 → 423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    4. XM_005564938.4 → XP_005564995.1  neuropilin-1 isoform X3

      UniProtKB/TrEMBL
      A0A2K5V5E7
      Related
      ENSMFAP00000019941.1
      Conserved Domains (6) summary
      cd06263
      Location:650 → 803
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:826 → 903
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:645 → 804
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:274 → 424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27 → 140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277 → 423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    5. XM_005564940.4 → XP_005564997.1  neuropilin-1 isoform X5

      UniProtKB/TrEMBL
      A0A2K5V5N0
      Related
      ENSMFAP00000019985.1
      Conserved Domains (3) summary
      smart00231
      Location:274 → 424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27 → 140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277 → 423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    Nucleotide Protein
    Heading Accession and Version

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